León vs Santos Laguna Prediction, Betting Tips, Lineups & Odds | 21 Feb 2026

Liga MX Betting Preview: León vs Santos Laguna

León meet Santos Laguna at Estadio Nou Camp, with kick-off set for 20:00 on Saturday 21 February.

Backing León -1 on the Asian Handicap means the insurance of money back if they beat Santos Laguna by a single goal. However, there’s a nice return at odds of -104 if the home team win by two or more.

Club León have been defeated in their last three games. Away from home, they recently suffered a 1-0 loss against Monterrey at Estadio BBVA. Ignacio Ambriz's team had 45% possession and recorded two shots on target.

Santos Laguna have suffered four straight away defeats. They lost 2-1 in their previous game at home to Mazatlán at Estadio Nuevo Corona. The Comarca Lagunera club enjoyed 54% possession and managed three shots on goal, with Lucas Di Yorio finding the net.

Head-to-Head Statistics

Santos have won the last two encounters against León, landing winning home scorelines of 2-0 and 2-1 at Estadio Nuevo Corona. The previous 10 H2H meetings have involved four León wins, three Santos victories and three draws.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
16	León	6	1	1	4	5	9	-4	5:9	4
18	Santos Laguna	6	0	1	5	6	19	-13	6:19	1

View Full Table

Club León have 1 win, 7 losses and 2 draws, averaging 0.7 goals from 3.3 shots on goal and 7.8 attempts. La Fiera have averaged 52.5% possession and 4.9 corners per match, conceding 1.6 goals and 5.2 corners from 5.6 shots on goal and 11.6 attempts.

Top goalscorer Diber Cambindo has found the net 2 times, with Rogelio Funes Mori, Ismael Diaz, Bryan Colula and Ivan Moreno scoring 1 each. Fernando Beltran and Ivan Moreno have racked up the most assists with 2 each.

Santos have won 2, lost 6 and drawn 2, with an average of 1.3 goals from 3.9 shots on goal and 8.2 attempts. Francisco Rodriguez's side have averaged 43.7% possession, 4.4 corners taken and 5.3 corners against, while conceding 2.6 goals from 6.5 shots on goal and 12.0 attempts.

Lucas Di Yorio and Fran Villalba top the team’s scoring charts on 3 goals, with Kevin Palacios on 2. Look no further than Ramiro Sordo for the top assist maker (3) in the last 10 games.

Predicted & Confirmed Lineups

León predicted lineup (4-3-3): Jordan Garcia (GK), Bryan Colula, Jaine Stiven Barreiro, Sebastian Vegas, Salvador Reyes, Daniel Arcila, Ivan Moreno, Rodrigo Echeverria, Juan Pablo Domínguez, Diber Cambindo, Nicolas Javier Vallejo.

Santos Laguna predicted lineup (4-2-3-1): Carlos Acevedo Lopez (GK), José Javier Abella, Kevin Balanta, Efraín Orona, Óscar Haret Ortega, Carlos Gruezo, Javier Güemez, Kevin Palacios, Fran Villalba, Cristian Dájome, Lucas Di Yorio.

León vs Santos Laguna Prediction & Betting Tips

Explore our best León vs Santos Laguna picks, including our main match prediction, top corners bet, correct score forecast, player performance props and a bet builder ready to use.

Match Prediction

The best Asian Handicap bet could be León -1 at -104, especially if you think that they can win handsomely. We are expecting the favourites to dominate when it comes to this Liga MX encounter.

Understanding the injured players situation proves useful when assembling football picks. Once we’ve also considered the form guide, we use the latest stats and provide Liga MX betting predictions.

Key León vs Santos Laguna league stats:

• The +1 line hasn’t been covered by Santos in 4 consecutive games on the road.
• The +1 line hasn’t been covered by Santos in 15 of their last 18 games on the road.
• The +1 line hasn’t been covered by Santos in 8 of their last 10 games on the road.

If you go by the top bookies, there’s a 51% likelihood of our pick winning. Taking all factors into consideration, our experts think there’s a stronger chance of success and estimate the probability to be closer to 60%. It’s the reason why we are recommending this bet.

Looking for a larger price when placing your wager? The good news is that you can visit the betting sites and adjust the line until you’re satisfied with the odds.

Discover the best value in betting. Our expert guide lists today’s top free bets, promo codes and new customer bonuses.

Our Match Prediction

León Asian Hcp -1 @ -104 Watch Live Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Feb 20, 02:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

León 3 - 1 Santos

León are available at +800 to win by a 3-1 scoreline. Correct score betting allows us to bet at bigger odds and it’s also a fun type of wager.

Player Prop Picks

Top Pick: Lucas Di Yorio to Score +350

Lucas Di Yorio (Santos) has managed three goals in his past four Liga MX matches. It’s worth a play on the +350 that he is Anytime Goalscorer as there’s lots of value for these betting odds.

Latest Lucas Di Yorio Player Prop Odds

Goalscorer

Anytime

+350

First

+950

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Corners Prediction

León Under 6.5 Corners -161

The 6.5 corners line has not been covered by León in their past eight home games, while the previous 5 Santos matches have seen them concede an average of 3.80 corners. We’re going to bet on León to fall short for Team Corners and this selection is available at -161.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

León

Total

10.10 4.90 5.20

Home

9.90 4.80 5.10

Away

9.80 5.10 4.70

Santos

Total

9.70 4.40 5.30

Home

10.20 4.40 5.80

Away

11.30 4.40 6.90

Latest Corner Odds

Total Corners

Over 9.5

-147

Under 9.5

-102

León Corners

Over 6.5

+102

Under 6.5

-161

Santos Corners

Over 3.5

-122

Under 3.5

-128

Most Corners

1

-270

X

+750

2

+255

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

León vs Santos Laguna Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Favourites Club León are regarded as the likeliest winners for this Liga MX clash. The -172 about them triumphing means a 63% chance of coming out on top based on their current betting odds. Santos Laguna are regarded as the least likely winner at +390.

There’s a nice alternative in the form of the Half-Time Result market. This allows you to back León at -100 to lead at the break or alternatively opt for Santos at +370. The draw is the third option at +150.

The expectation is that Over 2.5 Goals will be scored according to the latest odds. Should you expect both teams score, then the BTTS Yes option is available at -185.

The top football betting sites definitely give customers lots of choice. When it comes to Liga MX games, choose from hundreds of markets until you find the most attractive odds.

Full-Time Result

1

-172

X

+320

2

+390

Half-Time Result

1

-100

X

+150

2

+370

Double Chance

1X

-769

12

-588

X2

+117

Draw No Bet

1

-455

2

+260

Asian Handicap

1 Hcp -1

-104

2 Hcp +1

-123

Total Goals

Under 2.5

+143

Over 2.5

-200

Both Teams to Score

Yes

-185

No

+128

There is +120 available that Diber Armando Cambindo finds the net at any stage. He is available at +370 to register the first goal which makes him favourite.

Diber Armando Cambindo (León)

First

+120

Anytime

+370

Ismael Díaz (León)

First

+160

Anytime

+440

Rogelio Funes Mori (León)

First

+160

Anytime

+450

Ramiro Sordo (Santos)

First

+300

Anytime

+900

Rodrigo Echeverría (León)

First

+330

Anytime

+950

Lucas Di Yorio (Santos)

First

+350

Anytime

+950

Jordi Cortizo de la Piedra (León)

First

+370

Anytime

+1000

Ángel Estrada (León)

First

+370

Anytime

+1050

Fernando Beltrán (León)

First

+410

Anytime

+1200

Fran Villalba (Santos)

First

+430

Anytime

+1200

Juan Domínguez (León)

First

+450

Anytime

+1200

Ezequiel Bullaude (Santos)

First

+450

Anytime

+1400

Bryan Colula (León)

First

+480

Anytime

+1400

Cristian Dájome (Santos)

First

+500

Anytime

+1500

Iván Moreno (León)

First

+525

Anytime

+1500

Salvador Reyes (León)

First

+525

Anytime

+1500

Salvador Mariscal Murra (Santos)

First

+600

Anytime

+1800

Stiven Barreiro (León)

First

+650

Anytime

+1900

Paul Bellón (León)

First

+700

Anytime

+2000

Javier Güemez (Santos)

First

+700

Anytime

+2000

León have managed four losses, three victories and three draws in the last 10 home matches, recording an average of 1.50 goals per game and conceding 1.60.

Santos Laguna are winless over their previous ten games on their travels. The Comarca Lagunera club have clocked up eight losses and two draws in the past 10 away games, recording an average of 1.00 goals per match and conceding 2.90.

The previous Estadio Nou Camp encounter involved a 1-1 draw between León and Santos. The past 8 H2H meetings at Estadio Nou Camp have included five León wins along with three draws.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
León Home Stats		3-3-4	3.10	1.50	1.60	7	3	8	2
Santos Laguna Away Stats		0-2-8	3.90	1.00	2.90	9	1	7	3

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

Watch Liga MX live streaming through your Android or Apple device simply by having a funded sportsbook account or placing a bet within the past 24 hours.

Fans love the opportunity to watch thousands of sporting events per year with the best betting apps.

León vs Santos Laguna Live Streaming Watch Live Geo-restrictions apply. To use the services you need to be logged in, a funded account or to have placed a bet in the last 24 hours.

León vs Santos Laguna Lineups & Team News

Always review the León vs Santos team news before locking in your bets. Stay updated with our predicted and confirmed lineups for the Liga MX and the newest injury information.

León Team Page Santos Laguna Team Page

Top Football Pages