Mazatlán vs Santos Laguna Prediction, Betting Tips, Lineups & Odds | 21 Oct 2025

Liga MX Betting Preview: Mazatlán vs Santos Laguna

Mazatlán host Santos Laguna in this Liga MX fixture at Estadio El Encanto, with kick-off set for 23:00 on Tuesday 21 October. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

The odds of -149 look too good to pass up when it comes to both Mazatlán and Santos Laguna scoring here. A nice potential return is on the cards by taking this BTTS Yes option and we think it has a good chance.

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Mazatlán were defeated on the road in their last game. Guadalajara won 2-0 at Estadio Akron. Victor Vucetich's team were dominated in possession with 40% and didn’t have a single shot on target.

Santos Laguna have lost back-to-back Liga MX matches on their travels. In their previous league game, it was a 2-0 home victory over Club León at Estadio Nuevo Corona. The Comarca Lagunera outfit had just 38% of the ball and recorded five shots on goal, with Bruno Amione scoring twice.

Head-to-Head Statistics

Santos have not lost any of the past four matches against Mazatlán, with the last encounter seeing a 1-1 draw played out at Estadio El Encanto. The previous 10 H2H games have ended in five Santos victories, three draws and two Mazatlán wins.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
11	Santos Laguna	17	6	2	9	22	28	-6	22:28	20
16	Mazatlán	17	2	8	7	20	29	-9	20:29	14

View Full Table

1 win, 5 losses and 4 draws, averaging 1.3 goals from 6.1 attempts and 3.0 shots on goal. Mazatlán have had 46.6% possession and 3.5 corners per match. On average, the opposition have scored 2.1 goals from 9.3 attempts and 4.4 shots on goal, while earning 4.9 corners.

Nicolas Benedetti is the top scorer with 3 goals, while Anderson Duarte, Facundo Almada and Fabio Gomes each have 2. Mauro Lainez and Lucas Merolla are tied for the most assists on 2.

Santos have won 3, lost 6 and drawn 1, with an average of 3.6 shots on goal, 6.4 attempts and 1.0 goals. Francisco Rodriguez's side average 42.7% possession, 4.4 corners awarded and 7.4 corners against, while 1.6 goals have been conceded from 13.9 attempts and 7.1 shots on goal.

Cristian Dajome has scored 3, followed by Bruno Amione and Bruno Barticciotto with 2 goals apiece. Jose Abella has been top assists provider with 4 in the previous 10 games.

Confirmed Lineups

Mazatlán confirmed lineup (3-4-3): Daniel Gutierrez (GK), Bryan Colula, Facundo Almada, Angel Leyva, Jair Diaz, Jose Esquivel, Roberto Meraz, Anderson Duarte, Jesus Hernandez, Fabio Gomes, Mauro Lainez.

Santos Laguna confirmed lineup (4-1-4-1): Carlos Acevedo (GK), Jose Abella, Oscar Ortega, Kevin Balanta, Bruno Amione, Salvador Mariscal, Ramiro Sordo, Aldo Lopez, Javier Guemez, Anthony Lozano, Cristian Dajome.

Mazatlán vs Santos Laguna Prediction & Betting Tips

Prepare for Mazatlán vs Santos Laguna with our expert betting guide featuring a trusted match prediction, likely scoreline, top corners advice, key player props and a well-crafted bet builder.

Match Prediction

Both sides look capable of scoring when it comes to this Liga MX encounter, with readers recommended to visit the Both Teams to Score market and wager BTTS Yes at an appealing -149.

Understanding the injured players situation proves useful when assembling football picks. Once we’ve also considered the form guide, we use the latest stats and provide Liga MX betting predictions.

Key Mazatlán vs Santos Laguna league stats:

• BTTS Yes has been covered in 6 straight Mazatlán games at home.
• BTTS Yes has been covered in 9 of the last 10 Mazatlán games at home.
• BTTS Yes has been covered in 14 of the last 19 Mazatlán games at home.
• BTTS Yes has been covered in 3 of the last 5 Santos games on the road.
• BTTS Yes has been covered in 10 of the last 19 Santos games on the road.

If you go by the best football betting sites, our pick has a 59.9% chance of delivering a return. After careful examination, our tipsters calculate this probability to be somewhere between 65-70%. It’s the reason why we are recommending this bet.

If you think that BTTS Yes will happen but want to get a slightly bigger price, there’s the option to head to the Total Goals & Both Teams to Score market and combine it with Over 2.5 Goals.

Getting ready to place a wager? Check our updated guide for the latest betting offers, including free bets and the newest promos codes.

Our Match Prediction

Both Teams To Score - Yes @ -149 Bet Now

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Correct Score Prediction

Mazatlán 2 - 1 Santos

We’ve found an attractive bet at odds of +700 and it involves Mazatlán winning 2-1. We like a wager on correct score as there’s the chance to bank a bigger return.

Player Prop Picks

Top Pick: Ramiro Sordo Over 0.5 Shots On Target -120

Ramiro Sordo (Santos) can be backed at -120 to have at least one shot on goal. It’s hard to turn down such attractive odds for this player when it comes to Shots on Target.

Latest Ramiro Sordo Player Prop Odds

Goalscorer

Anytime

+300

First

+800

Shots On Target

Over 0.5

-120

Under 0.5

-130

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Facundo Almada to Score +575

Facundo Almada (Mazatlán) has managed two goals in his past five Liga MX games on home soil. There are odds of +575 on offer for this Anytime Goalscorer bet and we think this is an attractive wager for the player to be on the scoresheet.

Latest Facundo Almada Player Prop Odds

Goalscorer

Anytime

+575

First

+1500

Shots On Target

Over 0.5

+260

Under 0.5

-526

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Corners Prediction

Under 10.5 Corners -125

The 10.5 Total Corners line has not been covered in seven straight Mazatlán matches, with seven of the past ten Santos away games having the same outcome. The Total Corners line looks to be too high given the stats and -125 is available to wager.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Mazatlán

Total

8.40 3.50 4.90

Home

9.10 4.70 4.40

Away

9.70 4.00 5.70

Santos

Total

11.80 4.40 7.40

Home

10.50 4.70 5.80

Away

10.30 3.70 6.60

Latest Corner Odds

Total Corners

Over 9.5

-147

Under 9.5

-102

Mazatlán Corners

Over 5.5

-120

Under 5.5

-120

Santos Corners

Over 3.5

-150

Under 3.5

+110

Most Corners

1

-172

X

+650

2

+170

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Mazatlán vs Santos Laguna Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Mazatlán are regarded as having a 54% chance of winning this Liga MX clash in the eyes of the bookies. It means that their current betting odds are -118. If you want to get against the market leader, then you’re able to secure +270 for Santos Laguna.

The Asian Handicap -0.5 market is the same as a Full-Time Result wager, with Mazatlán needing to win at -114 for your bet to be successful. Santos +0.5 at -108 means you need them to triumph or the draw to happen.

The lowest odds can be found for Over 2.5 Goals, which means at least three goals being netted. For those expecting both sides to find the net, Both Teams to Score Yes is available at -149.

There are hundreds of markets which means lots of options to find a football bet for the latest Liga MX match. The best betting sites leave no stone unturned to provide a first-class service.

Full-Time Result

1

-118

X

+275

2

+270

Half-Time Result

1

+138

X

+130

2

+290

Double Chance

1X

-455

12

-455

X2

-125

Draw No Bet

1

-263

2

+170

Asian Handicap

1 Hcp -0.5

-114

2 Hcp +0.5

-108

Total Goals

Under 2.5

+102

Over 2.5

-137

Both Teams to Score

Yes

-149

No

+106

Fábio Netto is the market leader at +430 to be First Goalscorer but if you think he will score the last goal, then a similar price can be found.

Fábio Netto (Mazatlán)

First

+160

Anytime

+430

Bruno Barticciotto (Santos)

First

+240

Anytime

+650

Omar Moreno (Mazatlán)

First

+250

Anytime

+650

Ramiro Sordo (Santos)

First

+300

Anytime

+800

Yoel Bárcenas (Mazatlán)

First

+300

Anytime

+850

Nicolás Benedetti (Mazatlán)

First

+320

Anytime

+850

Jesus Hernandez (Mazatlán)

First

+380

Anytime

+1000

Mauro Laínez (Mazatlán)

First

+380

Anytime

+1000

Jordan Sierra Flores (Mazatlán)

First

+380

Anytime

+1000

Jordan Carrillo (Santos)

First

+400

Anytime

+1050

Fran Villalba (Santos)

First

+450

Anytime

+1150

Ronaldo Prieto (Santos)

First

+500

Anytime

+1400

Diego Javier Medina Vázquez (Santos)

First

+500

Anytime

+1200

Cristian Dájome (Santos)

First

+500

Anytime

+1300

Bryan Colula (Mazatlán)

First

+550

Anytime

+1500

Facundo Almada (Mazatlán)

First

+575

Anytime

+1500

Salvador Mariscal Murra (Santos)

First

+600

Anytime

+1600

Roberto Meraz (Mazatlán)

First

+600

Anytime

+1600

Jair Díaz (Mazatlán)

First

+600

Anytime

+1600

Alan Torres (Mazatlán)

First

+600

Anytime

+1700

Javier Güemez (Santos)

First

+700

Anytime

+1900

Sebastian Fierro (Mazatlán)

First

+750

Anytime

+2000

José Esquivel (Mazatlán)

First

+800

Anytime

+2200

Fábio Netto (Mazatlán)

Over 0.5

-244

Under 0.5

+133

Bruno Barticciotto (Santos)

Over 0.5

-175

Under 0.5

-100

Omar Moreno (Mazatlán)

Over 0.5

-123

Under 0.5

-141

Ramiro Sordo (Santos)

Over 0.5

-120

Under 0.5

-130

Yoel Bárcenas (Mazatlán)

Over 0.5

+118

Under 0.5

-189

Nicolás Benedetti (Mazatlán)

Over 0.5

+123

Under 0.5

-192

Jordan Carrillo (Santos)

Over 0.5

+128

Under 0.5

-204

Fran Villalba (Santos)

Over 0.5

+145

Under 0.5

-233

Jesus Hernandez (Mazatlán)

Over 0.5

+155

Under 0.5

-263

Mauro Laínez (Mazatlán)

Over 0.5

+160

Under 0.5

-263

Jordan Sierra Flores (Mazatlán)

Over 0.5

+163

Under 0.5

-270

Diego Javier Medina Vázquez (Santos)

Over 0.5

+170

Under 0.5

-286

Cristian Dájome (Santos)

Over 0.5

+175

Under 0.5

-294

Ronaldo Prieto (Santos)

Over 0.5

+180

Under 0.5

-313

Salvador Mariscal Murra (Santos)

Over 0.5

+205

Under 0.5

-357

Bryan Colula (Mazatlán)

Over 0.5

+245

Under 0.5

-476

Roberto Meraz (Mazatlán)

Over 0.5

+250

Under 0.5

-476

Javier Güemez (Santos)

Over 0.5

+250

Under 0.5

-476

Facundo Almada (Mazatlán)

Over 0.5

+260

Under 0.5

-526

Jair Díaz (Mazatlán)

Over 0.5

+260

Under 0.5

-500

José Esquivel (Mazatlán)

Over 0.5

+330

Under 0.5

-714

Mazatlán have five draws, three wins and two losses in the last 10 home matches, recording an average of 1.50 goals per game and conceding 1.70.

Santos Laguna haven’t triumphed in ten straight games on the road. The Comarca Lagunera outfit have collected nine defeats and one draw in the previous 10 away matches, scoring an average of 0.80 goals per game and conceding 2.30.

When previously meeting at Estadio El Encanto, Mazatlán and Santos played out a 1-1 draw. The past 5 H2H meetings at Estadio El Encanto have resulted in two Mazatlán victories and one Santos win. There have also been two draws.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Mazatlán Home Stats		3-5-2	3.20	1.50	1.70	6	4	9	1
Santos Laguna Away Stats		0-1-9	3.10	0.80	2.30	7	3	5	5

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

Mazatlán vs Santos Laguna Lineups & Team News

Avoid surprises — review the Mazatlán vs Santos team news before you bet. Stay in the know with our predicted and confirmed Liga MX lineups and the latest on injuries.

Mazatlán Team Page Santos Laguna Team Page

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