San Luis vs América Prediction, Betting Tips, Lineups & Odds | 24 Sep 2025

Liga MX Betting Preview: San Luis vs América

San Luis host América in this Liga MX encounter at Estadio Alfonso Lastras, with kick-off set for 23:00 on Wednesday 24 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Let’s take a chance on the BTTS Yes option when it comes to San Luis and América clashing. We really like the -156 that is available and feel confident that the teams can both find the net.

Confident in this BTTS pick? Unlock the new BetMGM promo code and check out our in-depth expert review before making your move.

Atlético San Luis triumphed in their last game which was away from home. Santos Laguna were beaten 4-1 at Estadio Nuevo Corona. Los Atléticos recorded eight shots on target and had 47% possession, with Joao Pedro scoring two, while Juan Sanabria and Benjamin Galdames also getting a goal.

Club América played out a 2-2 draw in their previous game. This was on their travels to Estadio BBVA, with Monterrey the opponents. Andre Jardine's men had 49% of possession and eight shots on goal, while Rodrigo Aguirre and Ramon Juarez found the net.

Head-to-Head Statistics

América beat San Luis at home when the teams last met. It was a 3-0 scoreline at Estadio Azteca. The previous 10 H2H meetings have seen América land seven wins and San Luis winning the other matches.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
4	América	17	10	4	3	33	18	15	33:18	34
15	San Luis	17	5	1	11	25	29	-4	25:29	16

View Full Table

San Luis have 4 wins, 5 losses and 1 draw, averaging 1.7 goals from 4.5 shots on goal and 7.5 attempts. Guillermo Abascal's team have averaged 48.1% possession and 4.3 corners per game, with their opponents scoring 1.6 goals from 5.4 shots on goal, 9.9 attempts and 5.6 corners.

Top scorer is Joao Pedro on 8 goals, while Benjamin Galdames has racked up 3 and Roman Torres 2. Sebastien Lamonge is the top assists maker on 2.

Club América have won 5, lost 2 and drawn 3, with an average of 9.3 attempts, 4.4 shots on goal and 1.8 goals. Las Águilas average 59.0% possession, 6.4 corners awarded and 3.7 corners against them, while 1.2 goals have been conceded from 3.1 shots on goal and 6.6 attempts.

Brian Rodriguez is top of the team’s scoring charts with 3, while Rodrigo Aguirre, Alex Zendejas, Allan Saint-Maximin and Erick Sanchez have 2. Brian Rodriguez has been top assists provider with 3 in the previous 10 games.

Confirmed Lineups

San Luis confirmed lineup (4-2-3-1): Andres Sanchez (GK), Roman Torres, Robson Bambu, Eduardo Aguila, Aldo Cruz, Oscar Macias, Rodrigo Dourado, Juan Sanabria, Sebastien Lamonge, Benjamin Galdames, Joao Pedro.

América confirmed lineup (3-2-4-1): Luis Malagon (GK), Sebastian Caceres, Ramon Juarez, Cristian Borja, Kevin Alvarez, Alexis Gutierrez, Victor Davila, Israel Reyes, Erick Sanchez, Brian Rodriguez, Rodrigo Aguirre.

San Luis vs América Prediction & Betting Tips

Head into San Luis vs América with expert betting insights, including our main match prediction, expected scoreline, top corners angle, key player props and a thoughtfully built bet builder.

Match Prediction

There’s an opportunity to bet on BTTS Yes when it comes to this Liga MX clash. The odds of -156 are really attractive and we anticipate that the teams will be among the goals.

Plenty of research goes into our football picks. It begins by focusing on the latest Liga MX form and knowing the injury situation. The important numbers can then be utilised to help complete the picture.

Key San Luis vs América league stats:

• BTTS Yes has been covered in 4 straight San Luis games.
• BTTS Yes has been covered in 7 of the last 10 San Luis games.
• BTTS Yes has been covered in 14 of the last 20 San Luis games.
• BTTS Yes has been covered in 5 straight América games on the road.
• BTTS Yes has been covered in 7 of the last 10 América games.
• BTTS Yes has been covered in 11 of the last 20 América games on the road.

The latest betting odds imply that our pick has a 61% prospect of winning. However, our tipsters have this number closer to 70% based on their in-depth research. This is why we can recommend this wager.

An alternative to BTTS Yes is going for Over 2.5 Goals to be scored. With this bet, it doesn’t matter which team scores providing that there are at least three goals in total.

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Our Match Prediction

Both Teams To Score - Yes @ -156 Bet Now

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Correct Score Prediction

San Luis 1 - 2 América

We’ve found an attractive bet at odds of +650 and it involves América winning 2-1. We like a wager on correct score as there’s the chance to bank a bigger return.

Player Prop Picks

Top Pick: Paul Brian Rodríguez Over 0.5 Shots On Target -114

Paul Brian Rodríguez (América) can be backed to finish with a minimum of one shot on goal at -114. In conclusion, we think that the odds offer plenty of appeal when it comes to betting on Shots on Target.

Latest Paul Brian Rodríguez Player Prop Odds

Goalscorer

Anytime

+240

First

+650

Shots On Target

Over 0.5

-114

Under 0.5

-139

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Allan Saint-Maximin to Score +370

Allan Saint-Maximin (América) has racked up two goals in his past four Liga MX games. We’ll use this stat and take odds of +370 that he is able to score at least one goal when it comes to wagering on Anytime Goalscorer.

Latest Allan Saint-Maximin Player Prop Odds

Goalscorer

Anytime

+380

First

+950

Shots On Target

Over 0.5

+112

Under 0.5

-182

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Corners Prediction

San Luis Under 4.5 Corners -138

San Luis have failed to cover the 4.5 corners line in three consecutive matches, with América conceding under 4.5 corners in their past four games. We think San Luis might fall short of the mark, with odds of -138 available when it comes to this Team Corners pick.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

San Luis

Total

9.90 4.30 5.60

Home

9.40 4.50 4.90

Away

12.00 5.50 6.50

América

Total

10.10 6.40 3.70

Home

9.70 6.30 3.40

Away

8.90 4.60 4.30

Latest Corner Odds

Total Corners

Over 9.5

-143

Under 9.5

-103

San Luis Corners

Over 3.5

-150

Under 3.5

+110

América Corners

Over 5.5

-110

Under 5.5

-125

Most Corners

1

+165

X

+600

2

-164

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San Luis vs América Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

The latest Club América odds are -152 which leads to them being favourites in this Liga MX clash. It’s also implied by the bookmakers that they have a 60% prospect of securing a victory. At +350, Atlético San Luis are regarded as having a lower probability of winning.

América -0.75 on the Asian Handicap is available at -116 and means a full payout if they win by two or more against San Luis. A victory by one goal means half the stake wins and the other half is refunded.

The odds suggest that Over 2.5 Goals is a strong probability in this exciting contest. For those expecting both sides to find the net, Both Teams to Score Yes is available at -156.

The best football betting sites cover Liga MX games in serious depth and there are hundreds of markets. We recommend scanning through the various bets before picking out the best angle.

Full-Time Result

1

+350

X

+300

2

-152

Half-Time Result

1

+350

X

+140

2

+114

Double Chance

1X

+102

12

-526

X2

-625

Draw No Bet

1

+230

2

-333

Asian Handicap

1 Hcp +0.75

-106

2 Hcp -0.75

-116

Total Goals

Under 2.5

+118

Over 2.5

-161

Both Teams to Score

Yes

-156

No

+110

Rodrigo Aguirre can be backed to find the net anytime at +160, with +450 available that the market leader scores the first goal.

Rodrigo Aguirre (América)

First

+160

Anytime

+450

João Galvão (San Luis)

First

+190

Anytime

+575

Patricio Salas (América)

First

+220

Anytime

+575

Paul Brian Rodríguez (América)

First

+240

Anytime

+650

Álex Zendejas (América)

First

+280

Anytime

+800

Javairô Dilrosun (América)

First

+300

Anytime

+800

Allan Saint-Maximin (América)

First

+380

Anytime

+950

Erick Sanchez (América)

First

+420

Anytime

+1150

Aarón Arredondo (América)

First

+450

Anytime

+1150

Juan Manuel Sanabria (San Luis)

First

+475

Anytime

+1300

Dagoberto Espinoza (América)

First

+500

Anytime

+1300

Jonathan dos Santos (América)

First

+575

Anytime

+1600

Benjamín Galdames (San Luis)

First

+575

Anytime

+1600

Israel Reyes (América)

First

+700

Anytime

+2000

Kevin Alvarez (América)

First

+750

Anytime

+2000

Miguel Vazquez (América)

First

+850

Anytime

+2200

Rodrigo Aguirre (América)

Over 0.5

-204

Under 0.5

+114

João Galvão (San Luis)

Over 0.5

-204

Under 0.5

+116

Patricio Salas (América)

Over 0.5

-147

Under 0.5

-118

Paul Brian Rodríguez (América)

Over 0.5

-114

Under 0.5

-139

Álex Zendejas (América)

Over 0.5

+108

Under 0.5

-172

Allan Saint-Maximin (América)

Over 0.5

+112

Under 0.5

-182

Javairô Dilrosun (América)

Over 0.5

+125

Under 0.5

-200

Erick Sanchez (América)

Over 0.5

+170

Under 0.5

-286

Juan Manuel Sanabria (San Luis)

Over 0.5

+188

Under 0.5

-370

Aarón Arredondo (América)

Over 0.5

+190

Under 0.5

-333

Dagoberto Espinoza (América)

Over 0.5

+230

Under 0.5

-417

Benjamín Galdames (San Luis)

Over 0.5

+230

Under 0.5

-500

Jonathan dos Santos (América)

Over 0.5

+270

Under 0.5

-526

Israel Reyes (América)

Over 0.5

+300

Under 0.5

-588

Kevin Alvarez (América)

Over 0.5

+310

Under 0.5

-667

San Luis haven’t triumphed in four straight games at Estadio Alfonso Lastras. Los Atléticos have five defeats, four victories and one draw in the last 10 home matches, netting an average of 1.20 goals per game and conceding 1.30.

América are unbeaten over their previous five games on the road. Andre Jardine's side have four draws, four losses and two victories in the last 10 away matches, recording an average of 1.10 goals per game and conceding 1.20.

The last Estadio Alfonso Lastras meeting saw San Luis beat América 2-1. América have won seven of the past 8 H2H games at Estadio Alfonso Lastras, with San Luis picking up one win.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
San Luis Home Stats		4-1-5	2.50	1.20	1.30	6	4	7	3
América Away Stats		2-4-4	2.30	1.10	1.20	3	7	5	5

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

San Luis vs América Lineups & Team News

Stay ahead of the game by checking the San Luis vs América team news before betting. We’ll share both predicted and confirmed lineups for the Liga MX along with the latest injury news.

San Luis Team Page América Team Page

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