Santos Laguna vs América Prediction, Betting Tips, Lineups & Odds | 04 Apr 2026

Liga MX Betting Preview: Santos Laguna vs América

Santos Laguna clash with América at Estadio Nuevo Corona, with kick-off set for 23:00 on Saturday 4 April.

Santos Laguna +1 on the Asian Handicap could be the order of the day. We can back them at -114 against América and benefit if the underdogs draw or win, while there’s stake back if they only lose by a single goal.

Santos Laguna were winners last time out. It was a 2-1 home win against Club Puebla at Estadio Nuevo Corona. Omar Tapia's men enjoyed 47% possession and had nine shots on target, while Ezequiel Bullaude and Aldo Lopez scored one goal apiece.

Club América were defeated in their previous game. On their travels, they suffered a 1-0 loss against Pumas UNAM at Olimpico Universitario. Las Águilas boasted 57% possession and had four shots on goal.

Head-to-Head Statistics

América have landed three straight victories over Santos. In the last clash, América secured a 3-0 win when hosting at Estadio de la Ciudad de los Deportes. The previous 10 H2H games have featured six América victories and four draws.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
8	América	12	5	2	5	13	11	2	13:11	17
18	Santos Laguna	12	2	2	8	14	30	-16	14:30	8

View Full Table

Santos have 2 wins, 6 losses and 2 draws, averaging 1.2 goals from 4.4 shots on goal and 9.1 attempts. Los Guerreros have averaged 46.3% possession and 5.0 corners per match, with the opposition scoring 2.4 goals from 5.7 shots on goal, 12.0 attempts and 3.8 corners.

Ezequiel Bullaude leads the way with 5 goals, Lucas Di Yorio has 3, with Aldo Lopez and two others on 1. Lucas Di Yorio is the top assists maker with 3.

Club América have won 5, lost 4 and drawn 1, with an average of 1.3 goals from 5.3 shots on goal and 11.7 attempts. There’s been an average of 60.6% possession, 4.6 corners taken and 3.7 corners against, while they’ve conceded 0.9 goals from 2.6 shots on goal and 6.7 attempts.

Brian Rodriguez has scored 3, followed by Raphael Veiga, Alex Zendejas and Victor Davila with 2 goals apiece. Brian Rodriguez and Raphael Veiga have had 2 assists in the previous 10 games.

Predicted & Confirmed Lineups

Santos Laguna predicted lineup (4-2-3-1): Carlos Acevedo Lopez (GK), Kevin Picón, Óscar Haret Ortega, Kevin Balanta, Emmanuel Echeverria, Javier Güemez, Aldo López Vargas, Cristian Dájome, Ezequiel Bullaude, Fran Villalba, Lucas Di Yorio.

América predicted lineup (4-2-3-1): Rodolfo Cota (GK), Israel Reyes Romero, Miguel Vazquez, Sebastián Cáceres, Cristian Borja, Erick Sánchez, Rodrigo Dourado, Alejandro Zendejas, Raphael Veiga, Brian Rodríguez, Patricio Salas.

Santos Laguna vs América Prediction & Betting Tips

Discover our expert Santos Laguna vs América betting tips, featuring a match prediction, correct score suggestion, corners market outlook, top player prop picks and bet builder advice. Scroll down for full analysis.

Match Prediction

In order for our Santos Laguna +1 bet to land at -114, we need the underdogs to win or draw this Liga MX game. We think they’ll make the game competitive and feel confident with this Asian Handicap wager.

We’re constantly keeping tabs on the Liga MX team news. Along with the latest form, this helps us get the value every time. Our football experts are able to take a stats-led approach, with the key numbers providing a guide.

Key Santos Laguna vs América league stats:

• The +1 line has been covered by Santos in 6 of their last 10 games at home.
• The +1 line has been covered by Santos in 3 of their last 5 games.
• The -1 line hasn’t been covered by América in 9 of their last 10 games on the road.
• The -1 line hasn’t been covered by América in 17 of their last 20 games on the road.
• The -1 line hasn’t been covered by América in 7 of their last 10 games against Santos.

The betting odds at the top bookies suggest our pick carries a 53.2% chance of winning. However, our tipsters research has found that the actual probability is closer to 60%. This bet can therefore be backed with confidence.

There are bigger prices on offer for bettors who are willing to move the line. If you want to take a different perspective on a team’s performance, more juice is up for grabs.

Before placing your bet, explore our exclusive betting promo codes, welcome offers, and best free bets for today.

Our Match Prediction

Santos Asian Hcp +1 @ -114 Watch Live Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Apr 3, 05:27). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Santos 2 - 2 América

The teams can be backed at +950 to play out a 2-2 scoreline. It can be fun to have a wager on the correct score and there’s a big potential return if the bet wins.

Player Prop Picks

Top Pick: Ezequiel Bullaude to Score +500

Ezequiel Bullaude (Santos) has registered three goals in his past five Liga MX matches. We think there’s value in backing him for an Anytime Goalscorer prop bet at +500 which will hopefully see him find the net.

Latest Ezequiel Bullaude Player Prop Odds

Goalscorer

Anytime

+500

First

+1500

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Corners Prediction

América Under 5.5 Corners -102

There’s been an average 3.80 América corners in their past 5 games, while Santos have conceded less than 5.5 corners in four consecutive matches. It looks a logical viewpoint that the Team Corners line won’t be reached and you can land a price of -102 for this América wager.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

8.80 5.00 3.80

Home

10.20 5.20 5.00

Away

10.10 4.30 5.80

América

Total

8.30 4.60 3.70

Home

8.60 5.30 3.30

Away

7.80 4.60 3.20

Latest Corner Odds

Total Corners

Over 9.5

-139

Under 9.5

-106

Santos Corners

Over 3.5

-137

Under 3.5

-115

América Corners

Over 5.5

-143

Under 5.5

-109

Most Corners

1

+220

X

+700

2

-227

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Santos Laguna vs América Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a roughly 64% chance of triumphing, the bookmakers aren’t giving too much away with their -179 betting odds for Club América winning this Liga MX clash. Santos Laguna are the underdogs at +425 which implies a lesser percentage prospect of winning.

América and Santos can be backed at +106 and +375 respectively on the Half-Time Result market. This is an ideal route for bettors who want a quick settlement and the draw is +140.

Over 2.5 Goals is available at shorter odds than Under 2.5 Goals as things stand. A different approach is a Both Teams to Score bet and Yes has been priced at -161.

If you’re betting on Liga MX matches, we recommend heading to the top football betting sites and scanning through the hundreds of markets. There’s a chance to bet pre-match and In-Play.

Full-Time Result

1

+425

X

+310

2

-179

Half-Time Result

1

+375

X

+140

2

+106

Double Chance

1X

+125

12

-500

X2

-769

Draw No Bet

1

+270

2

-500

Asian Handicap

1 Hcp +1

-123

2 Hcp -1

-105

Total Goals

Under 2.5

+120

Over 2.5

-167

Both Teams to Score

Yes

-161

No

+108

Those interested in Paul Brian Rodríguez to find the net anytime can get +180, with the favourite on offer to score the first goal at odds of +525.

Paul Brian Rodríguez (América)

First

+180

Anytime

+525

Patricio Salas (América)

First

+190

Anytime

+525

Álex Zendejas (América)

First

+230

Anytime

+650

Raphael Cavalcante Veiga (América)

First

+240

Anytime

+700

Lucas Di Yorio (Santos)

First

+290

Anytime

+800

Vinicius 'Lima' Moreira de Lima (América)

First

+310

Anytime

+850

Ramiro Sordo (Santos)

First

+320

Anytime

+900

Erick Sanchez (América)

First

+380

Anytime

+1050

Fran Villalba (Santos)

First

+450

Anytime

+1300

Ezequiel Bullaude (Santos)

First

+500

Anytime

+1500

Jonathan dos Santos (América)

First

+540

Anytime

+1500

Cristian Dájome (Santos)

First

+550

Anytime

+1500

Kevin Alvarez (América)

First

+650

Anytime

+1800

Israel Reyes (América)

First

+650

Anytime

+1800

Salvador Mariscal Murra (Santos)

First

+650

Anytime

+1800

Miguel Vazquez (América)

First

+700

Anytime

+2000

Néstor Araújo (América)

First

+750

Anytime

+2000

Sebastián Cáceres (América)

First

+750

Anytime

+2200

Cristián Borja (América)

First

+750

Anytime

+2200

Javier Güemez (Santos)

First

+800

Anytime

+2200

Aaron Mejia (América)

First

+800

Anytime

+2200

Santos have collected five victories, four losses and one draw in the last 10 home games, recording an average of 1.50 goals per match and conceding 1.50.

América have collected five losses, three draws and two victories in the past 10 away matches, scoring an average of 0.90 goals per game and conceding 1.10.

América were 4-1 victors against Santos last time out at Estadio Nuevo Corona. The previous 5 H2H games at Estadio Nuevo Corona have seen two América wins and three draws.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Santos Laguna Home Stats		5-1-4	3.00	1.50	1.50	7	3	7	3
América Away Stats		2-3-5	2.00	0.90	1.10	4	6	3	7

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Santos Laguna vs América Lineups & Team News

Always review the Santos vs América team news before locking in your bets. We’ll keep you posted with predicted and confirmed lineups for the Liga MX and all current injury news.

Santos Laguna Team Page América Team Page

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