Santos Laguna vs León Prediction, Betting Tips, Lineups & Odds | 18 Oct 2025

Liga MX Betting Preview: Santos Laguna vs León

Santos Laguna host León in this Liga MX game at Estadio Nuevo Corona, with kick-off set for 19:00 on Saturday 18 October. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

Back Santos to Make Life Difficult for León

We’re splitting our Asian Handicap stake between 0 and +0.5 when backing Santos Laguna +0.25 at -123 against León. We need the hosts to win for a maximum payout although the draw means we also get a return.

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Santos Beat León in their Last Clash

Santos Laguna have lost back-to-back Liga MX games. Away at Estadio de la Ciudad de los Deportes, Club América recently beat them 3-0. Los Guerreros had 43% possession and recorded two shots on target.

Club León have now been defeated in back-to-back league games. This includes losing at home to Deportivo Toluca by a 4-2 scoreline. Eduardo Berizzo's team had four shots on goal and 53% possession, while James Rodriguez and Jose Alvarado were both on target.

Head-to-Head Statistics

The last head-to-head saw Santos claim a 2-1 home win over León at Estadio Nuevo Corona. The previous 10 H2H games have featured five León wins, three draws and two Santos victories.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
12	León	12	3	3	6	12	22	-10	12:22	12
16	Santos Laguna	12	3	1	8	13	21	-8	13:21	10

View Full Table

2 wins, 7 losses and 1 draw, averaging 0.8 goals from 3.1 shots on goal and 6.2 attempts. Santos have had 43.0% possession and 4.2 corners per game. On average, their opponents have scored 1.7 goals from 6.4 shots on goal and 13.9 attempts, while being awarded 6.9 corners.

Top goalscorer Cristian Dajome has found the net 3 times, Bruno Barticciotto 2, with Kevin Balanta and two other players on 1. Jose Abella is the top assists maker with 2.

Club León have won 2, lost 5 and drawn 3, averaging 3.3 shots on goal, 9.0 attempts and 1.1 goals. La Fiera average 50.8% possession, 4.0 corners awarded and 5.3 corners against, while 2.1 goals have been conceded from 12.9 attempts and 6.3 shots on goal.

Ismael Diaz got 5 goals, James Rodriguez notched 2, while Jose Alvarado and two other players scored 1. The top assistors in the last 10 games are Ivan Moreno, James Rodriguez and Salvador Reyes who have all made 1.

Predicted & Confirmed Lineups

Santos Laguna predicted lineup (4-1-4-1): Carlos Acevedo Lopez (GK), José Javier Abella, Jonathan Pérez, Kevin Balanta, Bruno Amione, Salvador Mariscal, Cristian Dájome, Fran Villalba, Javier Güemez, Kevin Palacios, Jesús Ocejo.

León predicted lineup (4-2-3-1): Óscar Jiménez (GK), Jose David Ramírez, Jaine Stiven Barreiro, Paul Bellón, Óscar Villa, Fernando Beltrán, Rodrigo Echeverria, Jordi Cortizo, James Rodriguez, José Alfonso Alvarado, Rogelio Funes Mori.

Santos Laguna vs León Prediction & Betting Tips

Our Santos Laguna vs León betting outlook has it all, including a trusted match forecast, our predicted score, best corners advice, top player prop picks and a hand-picked bet builder.

Match Prediction

We’ll split our stake by backing Santos Laguna +0.25 at odds of -123 for this Asian Handicap wager. There’s every chance that we see a strong performance from the home team in this Liga MX encounter.

The Sportsgambler.com football experts keep abreast of the latest Liga MX team news and form guide considering they could have a bearing on the outcome. It’s also important for our readers to have access to stats.

Key Santos Laguna vs León league stats:

• The -0.25 line hasn’t been covered by León in 5 consecutive games.
• The -0.25 line hasn’t been covered by León in 9 of their last 10 games on the road.
• The -0.25 line hasn’t been covered by León in 16 of their last 20 games.
• The +0.25 line has been covered by Santos in 2 consecutive games against León.

Santos +0.25 Probability

According to the latest odds, our pick has a 55.2% chance of winning. Based on our in-depth research, we calculate the actual probability to be 60-65%. This is why we regard this as a value bet.

There’s the option to move the line for your pick and this enables bettors to get larger prices. If you’re prepared for additional risk, you can get more bang for your buck.

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Our Match Prediction

Santos Asian Hcp +0.25 @ -123 Watch Live Bet Now

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Correct Score Prediction

Santos 1 - 0 León

There could be merit in backing Santos to win 1-0. Odds of +950 are available about a correct score bet where a nice potential return is on the cards.

Player Prop Picks

Top Pick: Javier Güemez To Score +575

Javier Güemez (Santos) is available at +575 to be on the scoresheet. Using all information, we’ll head to the Anytime Goalscorer market where we can bet him to find the net at attractive odds.

Latest Javier Güemez Player Prop Odds

Goalscorer

Anytime

+575

First

+1700

Shots On Target

Over 0.5

+215

Under 0.5

-385

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Corners Prediction

León Over 4.5 Corners -150

The 4.5 corners line has been covered by León in their past three games, while the previous 10 Santos matches have seen them concede an average of 6.90 corners. We’re going to take the Overs for León Team Corners, with this line standing out and you can get odds of -150.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

11.10 4.20 6.90

Home

9.60 4.60 5.00

Away

10.30 3.70 6.60

León

Total

9.30 4.00 5.30

Home

8.70 4.30 4.40

Away

8.90 4.30 4.60

Latest Corner Odds

Total Corners

Over 10.5

+102

Under 10.5

-152

Santos Corners

Over 4.5

-138

Under 4.5

-100

León Corners

Over 4.5

-150

Under 4.5

+110

Most Corners

1

+106

X

+600

2

-103

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Santos Laguna vs León Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Bookies Giving León Plenty of Respect

The Club León betting odds are +125 which means that they’re favourites to land victory in this Liga MX encounter. It’s also suggested by the bookies that this team have a 44% chance of winning. At +175, Santos Laguna are regarded as having a lower probability of winning.

Should you want to back León to win but want money back if the game ends level, then there is -143 available on the Draw No Bet market. Opponents Santos have been chalked up at +105.

The Total Goals market indicates that Over 2.5 Goals is the betting favourite right now. If you are expecting both teams to score, there’s the chance to back Yes at -200 on the BTTS market.

You can find hundreds of markets for every Liga MX game, with the best betting sites creating lots of different options. Check out the pre-game and In-Play selections before placing your football bets.

Full-Time Result

1

+175

X

+275

2

+125

Half-Time Result

1

+215

X

+140

2

+163

Double Chance

1X

-185

12

-455

X2

-270

Draw No Bet

1

+105

2

-143

Asian Handicap

1 Hcp +0.25

-123

2 Hcp -0.25

-100

Total Goals

Under 2.5

+130

Over 2.5

-179

Both Teams to Score

Yes

-200

No

+138

Ismael Díaz is the First Goalscorer Favourite

Ismael Díaz is the market leader to be First Goalscorer at +500. Alternatively, there’s the chance to back him to find the net at any stage at +180.

Ismael Díaz (León)

First

+180

Anytime

+500

Bruno Barticciotto (Santos)

First

+180

Anytime

+575

Rogelio Funes Mori (León)

First

+190

Anytime

+525

Ramiro Sordo (Santos)

First

+220

Anytime

+650

James Rodríguez (León)

First

+310

Anytime

+900

Ettson Ayon (León)

First

+330

Anytime

+900

Jordan Carrillo (Santos)

First

+330

Anytime

+1000

Fran Villalba (Santos)

First

+350

Anytime

+1000

Diego Javier Medina Vázquez (Santos)

First

+400

Anytime

+1150

Ronaldo Prieto (Santos)

First

+400

Anytime

+1200

Rodrigo Echeverría (León)

First

+400

Anytime

+1150

Jordi Cortizo de la Piedra (León)

First

+410

Anytime

+1100

Cristian Dájome (Santos)

First

+420

Anytime

+1200

Ángel Estrada (León)

First

+420

Anytime

+1200

Héctor Uribe (León)

First

+450

Anytime

+1150

Carlos Cisneros (León)

First

+475

Anytime

+1200

Fernando Beltrán (León)

First

+475

Anytime

+1300

Salvador Mariscal Murra (Santos)

First

+475

Anytime

+1300

Sebastian Santos (León)

First

+500

Anytime

+1300

Javier Güemez (Santos)

First

+575

Anytime

+1700

Nicolás Fonseca (León)

First

+650

Anytime

+1800

Salvador Reyes (León)

First

+650

Anytime

+1900

Hugo Rodriguez (Santos)

First

+650

Anytime

+2000

Iván Moreno (León)

First

+700

Anytime

+2000

Stiven Barreiro (León)

First

+700

Anytime

+2000

Bruno Barticciotto (Santos)

Over 0.5

-227

Under 0.5

+125

Rogelio Funes Mori (León)

Over 0.5

-182

Under 0.5

+104

Ramiro Sordo (Santos)

Over 0.5

-147

Under 0.5

-108

Ismael Díaz (León)

Over 0.5

-128

Under 0.5

-122

Jordan Carrillo (Santos)

Over 0.5

+105

Under 0.5

-164

James Rodríguez (León)

Over 0.5

+110

Under 0.5

-175

Ettson Ayon (León)

Over 0.5

+114

Under 0.5

-200

Fran Villalba (Santos)

Over 0.5

+120

Under 0.5

-192

Diego Javier Medina Vázquez (Santos)

Over 0.5

+143

Under 0.5

-233

Ronaldo Prieto (Santos)

Over 0.5

+155

Under 0.5

-263

Cristian Dájome (Santos)

Over 0.5

+155

Under 0.5

-263

Jordi Cortizo de la Piedra (León)

Over 0.5

+160

Under 0.5

-270

Rodrigo Echeverría (León)

Over 0.5

+165

Under 0.5

-270

Ángel Estrada (León)

Over 0.5

+180

Under 0.5

-303

Héctor Uribe (León)

Over 0.5

+180

Under 0.5

-313

Salvador Mariscal Murra (Santos)

Over 0.5

+180

Under 0.5

-303

Carlos Cisneros (León)

Over 0.5

+185

Under 0.5

-333

Fernando Beltrán (León)

Over 0.5

+190

Under 0.5

-333

Sebastian Santos (León)

Over 0.5

+200

Under 0.5

-417

Javier Güemez (Santos)

Over 0.5

+215

Under 0.5

-385

Hugo Rodriguez (Santos)

Over 0.5

+260

Under 0.5

-500

Salvador Reyes (León)

Over 0.5

+300

Under 0.5

-625

Stiven Barreiro (León)

Over 0.5

+320

Under 0.5

-909

Six of Past Ten Santos Home Games Have Been Defeats

Santos have finished with six defeats and four wins in the past 10 home games, netting an average of 1.30 goals per match and conceding 1.90.

León have not triumphed in three straight away matches. Eduardo Berizzo's team have recorded seven defeats, two draws and one victory in the previous 10 away matches, netting an average of 0.70 goals per game and conceding 2.00.

The previous Estadio Nuevo Corona encounter involved a 2-1 Santos win against León. In the past 6 H2H games at Estadio Nuevo Corona, there have been three Santos victories, two León wins and a draw.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Santos Laguna Home Stats		4-0-6	3.20	1.30	1.90	7	3	5	5
León Away Stats		1-2-7	2.70	0.70	2.00	6	4	6	4

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

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Santos Laguna vs León Lineups & Team News

Don’t miss the latest Santos vs León team news before you bet. We’ll bring you the expected and confirmed lineups for the Liga MX along with up-to-date injury news.

Santos Laguna Team Page León Team Page