Santos Laguna vs San Luis Prediction, Betting Tips, Lineups & Odds | 21 Sep 2025

Liga MX Betting Preview: Santos Laguna vs San Luis

Santos Laguna host San Luis in this Liga MX clash at Estadio Nuevo Corona, with kick-off set for 19:00 on Sunday 21 September. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and both predicted and confirmed lineups.

We are sweet on the prospect of the net bulging when Santos Laguna clash with San Luis. On this basis, we will side with the Over 2.5 pick when it comes to Total Goals, feeling confident with the -156 that is on offer.

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Santos Laguna faced Atlas away when last in action. It was a 2-2 draw at Estadio Jalisco. Francisco Rodriguez's team had nine shots on target and enjoyed 64% possession, while Jonathan Perez Sanchez and Jesus Ocejo scored one goal each.

Atlético San Luis hosted Club Tijuana at Estadio Alfonso Lastras in their previous game, ending in a 1-1 draw. Los Atléticos were 49% in the possession stakes and had three shots on goal, with Benjamin Galdames on the scoresheet.

Head-to-Head Statistics

It has been three successive wins for San Luis when playing Santos. In their last clash, San Luis travelled to Estadio Nuevo Corona and landed a 3-2 victory. The previous 10 H2H meetings have yielded four wins apiece and two draws.

Liga MX		G	W	D	L	GF	GA	GD	GD	P
11	Santos Laguna	17	6	2	9	22	28	-6	22:28	20
15	San Luis	17	5	1	11	25	29	-4	25:29	16

View Full Table

2 wins, 7 losses and 1 draw, averaging 1.1 goals from 6.8 attempts and 3.1 shots on goal. Santos have had 46.0% possession and 4.0 corners per match. On average, the opposition have scored 1.9 goals from 12.9 attempts and 5.9 shots on goal, while earning 6.3 corners.

Top scorer Cristian Dajome has found the net 3 times, with Jesus Ocejo, Bruno Barticciotto and Ramiro Sordo getting 2 each. Jose Abella is the leading assists maker on 2.

San Luis have 3 victories, 6 defeats and 1 draw, with an average of 3.9 shots on goal, 7.1 attempts and 1.3 goals. Los Atléticos average 48.5% possession, 5.1 corners awarded and 5.7 corners against, while 1.6 goals have been conceded from 10.1 attempts and 5.3 shots on goal.

Joao Pedro has top scored with 6, while Benjamin Galdames and Roman Torres are next best on 2. Sebastien Lamonge has managed 2 assists in the last 10 games.

Confirmed Lineups

Santos Laguna confirmed lineup (4-3-3): Carlos Acevedo (GK), Jose Abella, Oscar Ortega, Kevin Balanta, Bruno Amione, Aldo Lopez, Javier Guemez, Kevin Palacios, Cristian Dajome, Bruno Barticciotto, Fran Villalba.

San Luis confirmed lineup (4-2-3-1): Andres Sanchez (GK), Roman Torres, Robson Bambu, Eduardo Aguila, Juan Sanabria, Oscar Macias, Sebastien Lamonge, Miguel Garcia, Sebastian Perez-Bouquet, Benjamin Galdames, Joao Pedro.

Santos Laguna vs San Luis Prediction & Betting Tips

Head into Santos Laguna vs San Luis with expert betting insights, including our main match prediction, expected scoreline, top corners angle, key player props and a thoughtfully built bet builder.

Match Prediction

There’s a strong chance that we’ll see at least three goals scored for this Liga MX game. As a result, we’ll go for Over 2.5 Goals and the available odds of -156 look really attractive.

The football betting tips are only provided once we have a handle on the team news and the latest form guide. We are also on point when it comes to the most valuable Liga MX stats.

Key Santos Laguna vs San Luis league stats:

• The 2.5 line has been covered in 13 of the last 20 Santos games.
• The 2.5 line has been covered in 6 of the last 10 Santos games.
• The 2.5 line has been covered in 7 of the last 10 San Luis games on the road.
• The 2.5 line has been covered in 13 of the last 20 San Luis games.
• The 2.5 line has been covered in the last 3 games between these teams.

The latest odds at the best betting sites suggest our pick carries a 61% chance of winning. However, we have this number closer to 70% based on our in-depth research. It is therefore regarded as a value wager.

If Over 2.5 Goals is something that appeals but you want more juice, consider the option of heading to the Result & Total Goals market. Adding this selection with a team to win is a potential way forward.

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Our Match Prediction

Over 2.5 Goals @ -156 Bet Now

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Correct Score Prediction

Santos 1 - 2 San Luis

There’s plenty of juice to be found by backing San Luis to win 2-1. We can’t pass up the odds of +750 when it comes to correct score betting and it’s a fun wager.

Player Prop Picks

Top Pick: Ramiro Sordo Over 0.5 Shots On Target -128

Ramiro Sordo (Santos) is available at -128 to have a minimum of one shot on goal. Shots on Target bettors should definitely consider him at the available odds and we’ll have a play.

Latest Ramiro Sordo Player Prop Odds

Goalscorer

Anytime

+210

First

+600

Shots On Target

Over 0.5

-139

Under 0.5

-114

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Benjamín Galdames to Score +420

Benjamín Galdames (San Luis) has registered two goals in his past nine Liga MX matches. We think this is the pick of the player props, with a generous +420 available when it comes to backing him to score at any time.

Latest Benjamín Galdames Player Prop Odds

Goalscorer

Anytime

+420

First

+1100

Shots On Target

Over 0.5

+185

Under 0.5

-357

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Corners Prediction

San Luis Over 5.5 Corners -111

The 5.5 corners line has been covered by San Luis in five consecutive away games, while Santos have conceded 7.60 corners on average in their last 5 matches. We think that there’s a strong case for this outcome and we’ll back San Luis to cover the Team Corners line which is available at odds of -111.

League Games

League Games

Last 10 Total For Against

Last 10 at Home Total For Against

Last 10 Away Total For Against

Santos

Total

10.30 4.00 6.30

Home

10.40 4.70 5.70

Away

11.50 4.60 6.90

San Luis

Total

10.80 5.10 5.70

Home

9.40 4.50 4.90

Away

11.90 5.50 6.40

Latest Corner Odds

Total Corners

Over 10.5

-147

Under 10.5

-102

Santos Corners

Over 5.5

+110

Under 5.5

-150

San Luis Corners

Over 4.5

-150

Under 4.5

+110

Most Corners

1

+108

X

+650

2

-102

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Santos Laguna vs San Luis Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

The bookies have priced up the Full-Time Result betting odds and Atlético San Luis are +145 to land a Liga MX victory, while Santos Laguna are +155 to win. The draw is trading at +265 should you think the clash will end all square.

There are various ways to back San Luis and one option is the Asian Handicap -0.25. There’s +116 currently available that they beat Santos and there’s half a stake refund if the scoreline ends level.

The odds suggest that Over 2.5 Goals is a strong probability in this exciting contest. If you’re anticipating that both teams will score, the BTTS Yes option can be wagered at -182.

The best football betting sites provide bettors with an abundance of options. For every Liga MX game, you’re able to select from hundreds of markets and make the best choice.

Full-Time Result

1

+155

X

+265

2

+145

Half-Time Result

1

+200

X

+130

2

+190

Double Chance

1X

-217

12

-435

X2

-233

Draw No Bet

1

-111

2

-120

Asian Handicap

1 Hcp +0.25

-147

2 Hcp -0.25

+116

Total Goals

Under 2.5

+116

Over 2.5

-156

Both Teams to Score

Yes

-182

No

+128

João Galvão is available at +135 when it comes to Anytime Goalscorer, with the favourite priced at odds of +380 to find the net first.

João Galvão (San Luis)

First

+135

Anytime

+380

Bruno Barticciotto (Santos)

First

+180

Anytime

+525

Ramiro Sordo (Santos)

First

+210

Anytime

+600

Jordan Carrillo (Santos)

First

+330

Anytime

+950

Fran Villalba (Santos)

First

+350

Anytime

+950

Juan Manuel Sanabria (San Luis)

First

+360

Anytime

+1000

Diego Javier Medina Vázquez (Santos)

First

+400

Anytime

+1150

Ronaldo Prieto (Santos)

First

+400

Anytime

+1150

Cristian Dájome (Santos)

First

+400

Anytime

+1150

Benjamín Galdames (San Luis)

First

+420

Anytime

+1100

Salvador Mariscal Murra (Santos)

First

+460

Anytime

+1300

Javier Güemez (Santos)

First

+550

Anytime

+1600

Julio Domínguez (San Luis)

First

+650

Anytime

+1800

Hugo Rodriguez (Santos)

First

+650

Anytime

+1900

Daniel Guillén (San Luis)

First

+700

Anytime

+2000

Emmanuel Echeverria (Santos)

First

+700

Anytime

+2000

Bruno Amione (Santos)

First

+750

Anytime

+2000

Bruno Barticciotto (Santos)

Over 0.5

-204

Under 0.5

+115

Ramiro Sordo (Santos)

Over 0.5

-139

Under 0.5

-114

Jordan Carrillo (Santos)

Over 0.5

+110

Under 0.5

-172

Fran Villalba (Santos)

Over 0.5

+128

Under 0.5

-233

Juan Manuel Sanabria (San Luis)

Over 0.5

+148

Under 0.5

-270

João Galvão (San Luis)

Over 1.5

+160

Under 1.5

-303

Diego Javier Medina Vázquez (Santos)

Over 0.5

+160

Under 0.5

-278

Cristian Dájome (Santos)

Over 0.5

+163

Under 0.5

-303

Ronaldo Prieto (Santos)

Over 0.5

+170

Under 0.5

-286

Benjamín Galdames (San Luis)

Over 0.5

+185

Under 0.5

-357

Salvador Mariscal Murra (Santos)

Over 0.5

+195

Under 0.5

-345

Javier Güemez (Santos)

Over 0.5

+220

Under 0.5

-476

Hugo Rodriguez (Santos)

Over 0.5

+280

Under 0.5

-556

Julio Domínguez (San Luis)

Over 0.5

+290

Under 0.5

-588

Daniel Guillén (San Luis)

Over 0.5

+320

Under 0.5

-667

Bruno Amione (Santos)

Over 0.5

+340

Under 0.5

-1000

Santos have clocked up six losses and four wins in the past 10 home games, recording an average of 1.30 goals per match and conceding 1.60.

San Luis have finished with seven defeats and three wins in the past 10 away games, netting an average of 1.40 goals per match and conceding 2.10.

The last Estadio Nuevo Corona meeting saw San Luis beat Santos 3-2. The 6 H2H games most recently played at Estadio Nuevo Corona have included three Santos victories, one draw and two triumphs for San Luis.

Last 10 League Games		W-D-L	G	GF	GA	O2.5	U2.5	B-Y	B-No
Santos Laguna Home Stats		4-0-6	2.90	1.30	1.60	6	4	4	6
San Luis Away Stats		3-0-7	3.50	1.40	2.10	7	3	6	4

• W-D-L = Wins-Draws-Losses
• G = Avg. Goals
• GF = Avg. Goals For
• GA = Avg. Goals Against
• O2.5 = Matches Over 2.5 Goals
• U2.5 = Matches Under 2.5 Goals
• B-Y = Matches BTTS Yes
• B-No = Matches BTTS No

Santos Laguna vs San Luis Lineups & Team News

Make sure to look over the Santos vs San Luis team news before betting. Stay in the know with our predicted and confirmed Liga MX lineups and the latest on injuries.

Santos Laguna Team Page San Luis Team Page

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