Central Michigan vs Pittsburgh Prediction, Picks & Odds | 06 Sep 2025

College Football Betting Preview: Central Michigan vs Pitt Panthers

Central Michigan go up against Pitt Panthers in this NCAAF Week 2 matchup at Acrisure Stadium, with kickoff scheduled for 12:00 on Saturday 6 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Pitt Could Enjoy a Big Victory

We’re predicting a one-sided affair when Pitt Panthers play Central Michigan. Take the favorites at -110 to cover an appealing -21.5 line on the spread.

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Each Team Bidding to Secure Another Win

Central Michigan Chippewas got the win in their previous game. A 16-14 triumph occurred on the road at CEFCU Stadium when playing San Jose State Spartans.

Pittsburgh Panthers won their last game, beating Duquesne Dukes at home. It was a 61-9 win at Acrisure Stadium.

Central Michigan vs Pittsburgh Prediction & Picks

Our Central Michigan vs Pittsburgh betting outlook has it all, including a trusted match forecast, our predicted score, top player prop picks and a hand-picked bet builder.

Game Prediction

We strongly fancy the chances of Pitt Panthers beating the underdogs handsomely in this college football matchup. That is why we’re betting them at -21.5 on the spread at -110.

Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.

Key Central Michigan vs Pittsburgh stats:

• The -21.5 line has been covered by Pittsburgh in 4 of their last 10 games at home.

Pitt -21.5 Probability

The top sportsbooks are estimating that there is a 52.4% likelihood of this pick winning. However, we think that the probability is close to 60% taking all factors into consideration. It's therefore regarded as a value wager.

If you want to back Pitt without taking them on the point spread, there’s the alternative to go for a Winning Margin wager instead. There are lots of different options here.

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Best Bet

Pitt -21.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: Eli Holstein Over 262.5 Passing Yards -114

You can back Eli Holstein (Pitt) at -114 to exceed 262.5 passing yards. We’re happy to take him to cover the QB Passing Yards line and bettors can place this wager with confidence.

Latest Eli Holstein Player Prop Odds

Passing Yards

Over 252.5

-114

Under 252.5

-114

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Desmond Reid Over 75.5 Rushing Yards -114

Desmond Reid (Pitt) is priced at -114 to accumulate over 75.5 rushing yards. The line for him on the Overs is highly appealing, with Player Rushing Yards bettors able to get plenty of juice.

Latest Desmond Reid Player Prop Odds

Rushing Yards

Over 75.5

-114

Under 75.5

-114

Correct Score Prediction

Central Michigan 7 - 35 Pittsburgh

Should you wish to go for a speculative bet, try Pittsburgh to triumph 35-7 on the correct score lines. This should be a fun wager which could potentially yield a huge return.

Central Michigan vs Pittsburgh Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make Pitt Big Favorites

At betting odds of -2000 with the sportsbooks, Pittsburgh are regarded as 95% likely to win this college game. Central Michigan are the underdogs at +980 and they’re regarded as least likely to win.

The current spread is 21.5 and the total points line is 50.5. The beauty of the Totals is that you only have to choose from one of two options. Those that want to back Under 50.5 can find odds of -115 available.

When it comes to college football, the top betting apps deliver a wide variety of game lines and team props. With so many options available, it’s worth taking your time to find the wager that fits your view of the matchup.

Moneyline

CMU

+980

Pitt

-2000

Point Spread

CMU +21.5

-110

Pitt -21.5

-110

Total Points

Under 50.5

-115

Over 50.5

-105

Player Odds

Receiving Yards

Kenny Johnson (Pitt)

Over 54.5

-114

Under 54.5

-114

Cataurus Hicks (Pitt)

Over 53.5

-114

Under 53.5

-114

Raphael Williams Jr. (Pitt)

Over 40.5

-114

Under 40.5

-114

Malachi Thomas (Pitt)

Over 22.5

-114

Under 22.5

-114

Rushing Yards

Desmond Reid (Pitt)

Over 75.5

-114

Under 75.5

-114

Pitt Sitting on Seven Wins in Past Ten at Home

Pitt own a 7-3 mark in their past 10 home games, scoring 35.50 points per contest and conceding 20.00.

Central Michigan have one win and nine losses in the last 10 games on the road, putting up 17.30 points on average and giving up 33.70.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Pittsburgh Home Stats		7-3	55.50	35.50	20.00	5	5
Central Michigan Away Stats		1-9	51.00	17.30	33.70	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Central Michigan Chippewas Stats

Pittsburgh Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 1 win and 9 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +21.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +21.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -21.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -21.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 47.40 pts in the previous 10 games
• Game Totals on the Road: An average of 51.00 pts in the previous 10 games on the road
• Over 50.5: Covered in 4 of the previous 10 games
• Over 50.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.60 pts and allowed 27.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.30 pts and allowed 33.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 57.10 pts in the previous 10 games
• Game Totals at Home: An average of 55.50 pts in the previous 10 home games
• Over 50.5: Covered in 6 of the previous 10 games
• Over 50.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 29.50 pts and allowed 27.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.50 pts and allowed 20.00 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Boston College	1	0	66	10	56	1-0	0-0	1W
NC State	1	0	24	17	7	1-0	0-0	1W
Wake Forest	1	0	10	9	1	1-0	0-0	1W
Virginia	1	0	48	7	41	1-0	0-0	1W
SMU	1	0	42	13	29	1-0	0-0	1W
California	1	0	34	15	19	0-0	1-0	1W
Pittsburgh	1	0	61	9	52	1-0	0-0	1W
Miami	1	0	27	24	3	1-0	0-0	1W
Louisville	1	0	51	17	34	1-0	0-0	1W
Georgia Tech	1	0	27	20	7	0-0	1-0	1W
Florida State	1	0	31	17	14	1-0	0-0	1W
Duke	1	0	45	17	28	1-0	0-0	1W
Clemson	0	1	10	17	-7	0-1	0-0	1L
North Carolina	0	1	14	48	-34	0-1	0-0	1L
Stanford	0	1	20	23	-3	0-0	0-1	1L
Syracuse	0	1	26	45	-19	0-0	0-1	1L
Virginia Tech	0	1	11	24	-13	0-0	0-1	1L

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Bowling Green	1	0	26	7	19	1-0	0-0	1W
Central Michigan	1	0	16	14	2	0-0	1-0	1W
Kent State	1	0	21	17	4	1-0	0-0	1W
Northern Illinois	1	0	19	17	2	1-0	0-0	1W
Akron	0	1	0	10	-10	0-1	0-0	1L
Ball State	0	1	0	31	-31	0-0	0-1	1L
Buffalo	0	1	10	23	-13	0-0	0-1	1L
Eastern Michigan	0	1	27	52	-25	0-0	0-1	1L
Massachusetts	0	1	10	42	-32	0-1	0-0	1L
Miami (OH)	0	1	0	17	-17	0-0	0-1	1L
Ohio	0	1	31	34	-3	0-0	0-1	1L
Toledo	0	1	16	24	-8	0-0	0-1	1L
Western Michigan	0	1	6	23	-17	0-0	0-1	1L