Clemson vs North Carolina Prediction, Picks & Odds | 04 Oct 2025
College Football Betting Preview: Clemson vs North Carolina
Clemson battle North Carolina in this NCAAF Week 6 matchup at Kenan Stadium, with kickoff scheduled for 12:00 on Saturday, October 4. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
We’ve got a strong opinion when North Carolina go up against Clemson. Our prediction is that there will be Over 46.5 points and that is available at -110 on the totals.
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Clemson Tigers suffered a second consecutive defeat when losing 34-21 in their previous game. This was at home to Syracuse Orange at Memorial Stadium.
North Carolina Tar Heels suffered a defeat in their last game. A 34-9 scoreline occurred on the road at Acrisure Bounce House against UCF Knights.
Head-to-Head Statistics
Clemson triumphed 31-20 when they last played North Carolina. This head-to-head was played at Memorial Stadium. It’s been a succession of Clemson wins in the past 3 H2H meetings.
Clemson vs North Carolina Prediction & Picks
Unlock a complete betting breakdown for Clemson vs North Carolina, featuring our expert match prediction, expected final score, standout player prop picks and a ready-to-play bet builder.
Game Prediction
There’s juice available when it comes to backing Over 46.5 points in this college football showdown and that’s the betting angle we’re pursuing. Our pick is priced up at -110 which looks worth taking.
The CFB handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.
Key Clemson vs North Carolina stats:
Over 46.5 Probability
The top betting apps make it a 52.4% chance that our pick is settled as a winner. However, we think that the probability sits between 55-60% taking all factors into consideration. It’s the reason why we are recommending this college bet.
The sportsbooks allow you to shoot for bigger odds by moving the line on the Totals. Choose a number where you’re happy and get more juice.
Considering placing a bet? Explore today’s best welcome bonuses and sign-up offers in our full guide before you get started.
Player Prop Picks
The odds for Cade Klubnik (Clemson) to go over 257.5 passing yards stand at -114. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.
The odds for Bryant Wesco Jr. (Clemson) to make it to the end zone are +110. He looks like a value pick and we think that the odds offer plenty of appeal when it comes to wagering on Anytime Touchdown Scorer.
Same Game Parlay Picks
Our same game parlay pick is Over 46.5, North Carolina +14.5 on the spread and Cade Klubnik (Clemson) to go Over 257.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
28
-
21
North Carolina
There is a speculative bet that can be enjoyed on Clemson when it comes to the correct score lines. Taking them to win 28-21 should provide some entertainment.
Clemson vs North Carolina Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Clemson are massive -833 favorites. They are regarded as 89% likely to win this college game judging by the sportsbooks’ latest Moneyline odds. North Carolina are regarded as a long shot to win and you can currently back them at +570.
15.5 is where the spread lies, with total points being 48.5 right now. A wager on the Totals allows football bettors to use the latest data to good effect. There’s an opportunity to bet Over 48.5 at -105.
The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.
The First Touchdown Scorer favorite is Adam Randall at +270. Similar odds can be found if you’re interested in this player to register the final TD.
Touchdown
Receiving Yards
Rushing Yards
Instead of focusing on the overall outcome, some bettors prefer to look at the college football micro betting lines. As the name suggests, it means placing short-term in-game wagers and this might include the Next Play or Next Drive Result.
North Carolina Sitting on Five Wins in Previous Ten at Home
North Carolina have five wins and five losses in the last 10 home games, putting up 35.40 points per contest and giving up 33.30.
Clemson have seven wins and three losses in the last 10 road games, averaging 26.20 points on offense and surrendering 23.00 on defense.
Clemson beat North Carolina 39-10 when they last met at Kenan Stadium.
| Last 10 Games | W-L | P | PF | PA | O46.5 | U46.5 | |
|---|---|---|---|---|---|---|---|
 North Carolina Home Stats |
5-5 | 68.70 | 35.40 | 33.30 | 10 | 0 | |
 Clemson Away Stats |
7-3 | 49.20 | 26.20 | 23.00 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O46.5 = Games Over 46.5 Points
- U46.5 = Games Under 46.5 Points
Latest regular season and playoff games stats.
Clemson Tigers Stats
North Carolina Tar Heels Stats
- 5 wins and 5 defeats in the last 10 games
- 7 wins and 3 defeats in the last 10 games on the road
- -14.5 Betting Line: Have covered the spread in 1 of the last 10 games
- -14.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road
- +14.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +14.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games
- Game Totals: An average of 47.50 pts in the previous 10 games
- Game Totals on the Road: An average of 49.20 pts in the previous 10 games on the road
- Over 46.5: Covered in 4 of the previous 10 games
- Over 46.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 25.00 pts and allowed 22.50 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 26.20 pts and allowed 23.00 pts in the last 10 games on the road
- Game Totals: An average of 49.90 pts in the previous 10 games
- Game Totals at Home: An average of 63.60 pts in the previous 10 home games
- Over 46.5: Covered in 6 of the previous 10 games
- Over 46.5 at Home: Covered in 9 of the previous 10 home games
- Team Totals: Have scored an average of 25.60 pts and allowed 24.30 pts in the last 10 games
- Team Totals at Home: Have scored an average of 32.10 pts and allowed 31.50 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
|
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
|
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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