Clemson vs North Carolina Prediction, Picks & Odds | 04 Oct 2025

College Football Betting Preview: Clemson vs North Carolina

Clemson battle North Carolina in this NCAAF Week 6 matchup at Kenan Stadium, with kickoff scheduled for 12:00 on Saturday 4 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

The Total Line Could Be Too Low

We’ve got a strong opinion when North Carolina go up against Clemson. Our prediction is that there will be Over 46.5 points and that is available at -110 on the totals.

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Clemson Beat UNC in Pair’s Previous Clash

Clemson Tigers suffered a second consecutive defeat when losing 34-21 in their previous game. This was at home to Syracuse Orange at Memorial Stadium.

North Carolina Tar Heels suffered a defeat in their last game. A 34-9 scoreline occurred on the road at Acrisure Bounce House against UCF Knights.

Head-to-Head Statistics

Clemson triumphed 31-20 when they last played North Carolina. This head-to-head was played at Memorial Stadium. It’s been a succession of Clemson wins in the past 3 H2H meetings.

Clemson vs North Carolina Prediction & Picks

Unlock a complete betting breakdown for Clemson vs North Carolina, featuring our expert match prediction, expected final score, standout player prop picks and a ready-to-play bet builder.

Game Prediction

There’s juice available when it comes to backing Over 46.5 points in this college football showdown and that’s the betting angle we’re pursuing. Our pick is priced up at -110 which looks worth taking.

The CFB handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.

Key Clemson vs North Carolina stats:

• The 46.5 line has been covered in 11 of the last 20 Clemson games.
• The 46.5 line has been covered in 9 of the last 10 North Carolina games at home.
• The 46.5 line has been covered in 18 of the last 20 North Carolina games at home.
• The 46.5 line has been covered in the last 2 North Carolina games at home.
• The 46.5 line has been covered in the last 2 games between these teams.

Over 46.5 Probability

The top betting apps make it a 52.4% chance that our pick is settled as a winner. However, we think that the probability sits between 55-60% taking all factors into consideration. It’s the reason why we are recommending this college bet.

The sportsbooks allow you to shoot for bigger odds by moving the line on the Totals. Choose a number where you’re happy and get more juice.

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Best Bet

Over 46.5 Points @ -110 Bet Now

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Player Prop Picks

Top Pick: Cade Klubnik Over 257.5 Passing Yards -114

The odds for Cade Klubnik (Clemson) to go over 257.5 passing yards stand at -114. There’s an opportunity to place a QB Passing Yards bet, with him capable of covering an appealing line.

Latest Cade Klubnik Player Prop Odds

Touchdown

Anytime

+120

First

+800

Passing Yards

Over 257.5

-114

Under 257.5

-114

Rushing Yards

Over 23.5

-114

Under 23.5

-114

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Bryant Wesco Jr. Anytime TD +110

The odds for Bryant Wesco Jr. (Clemson) to make it to the end zone are +110. He looks like a value pick and we think that the odds offer plenty of appeal when it comes to wagering on Anytime Touchdown Scorer.

Latest Bryant Wesco Jr. Player Prop Odds

Touchdown

Anytime

-100

First

+550

Receiving Yards

Over 68.5

-114

Under 68.5

-114

Correct Score Prediction

Clemson 28 - 21 North Carolina

There is a speculative bet that can be enjoyed on Clemson when it comes to the correct score lines. Taking them to win 28-21 should provide some entertainment.

Clemson vs North Carolina Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Clemson Heavy Favorites to Win

Clemson are massive -769 favorites. They are regarded as 88% likely to win this college game judging by the sportsbooks’ latest Moneyline odds. North Carolina are regarded as a long shot to win and you can currently back them at +540.

14.5 is where the spread lies, with total points being 46.5 right now. A wager on the Totals allows football bettors to use the latest data to good effect. There’s an opportunity to bet Over 46.5 at -110.

The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.

Moneyline

Clemson

-769

UNC

+540

Point Spread

Clemson -14.5

-115

UNC +14.5

-105

Total Points

Under 46.5

-110

Over 46.5

-110

Adam Randall Favorite to Score First TD

The First Touchdown Scorer favorite is Adam Randall at +290. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Adam Randall (Clemson)

First TD

+290

Anytime TD

-278

Bryant Wesco Jr. (Clemson)

First TD

+550

Anytime TD

-100

Antonio Williams (Clemson)

First TD

+550

Anytime TD

-100

Cade Klubnik (Clemson)

First TD

+800

Anytime TD

+120

Demon June (UNC)

First TD

+850

Anytime TD

+125

T.J. Moore (Clemson)

First TD

+900

Anytime TD

+180

Jordan Shipp (UNC)

First TD

+1600

Anytime TD

+280

Benjamin Hall (UNC)

First TD

+1700

Anytime TD

+310

Tyler Brown (Clemson)

First TD

+1900

Anytime TD

+300

Chris Culliver (UNC)

First TD

+2500

Anytime TD

+460

Javarius Green (UNC)

First TD

+2500

Anytime TD

+490

Josh Sapp (Clemson)

First TD

+2700

Anytime TD

+550

Jake Johnson (UNC)

First TD

+2700

Anytime TD

+500

Max Johnson (UNC)

First TD

+4000

Anytime TD

+900

Alex Taylor (UNC)

First TD

+5000

Anytime TD

+950

Receiving Yards

Bryant Wesco Jr. (Clemson)

Over 68.5

-114

Under 68.5

-114

Antonio Williams (Clemson)

Over 68.5

-114

Under 68.5

-114

T.J. Moore (Clemson)

Over 39.5

-114

Under 39.5

-114

Rushing Yards

Adam Randall (Clemson)

Over 87.5

-114

Under 87.5

-114

Cade Klubnik (Clemson)

Over 23.5

-114

Under 23.5

-114

North Carolina Sitting on Five Wins in Previous Ten at Home

North Carolina have five wins and five losses in the last 10 home games, putting up 35.40 points per contest and giving up 33.30.

Clemson have seven wins and three losses in the last 10 road games, averaging 26.20 points on offense and surrendering 23.00 on defense.

Clemson beat North Carolina 39-10 when they last met at Kenan Stadium.

Last 10 Games		W-L	P	PF	PA	O46.5	U46.5
North Carolina Home Stats		5-5	68.70	35.40	33.30	10	0
Clemson Away Stats		7-3	49.20	26.20	23.00	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O46.5 = Games Over 46.5 Points
• U46.5 = Games Under 46.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Clemson Tigers Stats

North Carolina Tar Heels Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -14.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -14.5 Betting Line on the Road: Have covered the spread in 2 of the last 10 games on the road

Point Spread

• +14.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +14.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 47.50 pts in the previous 10 games
• Game Totals on the Road: An average of 49.20 pts in the previous 10 games on the road
• Over 46.5: Covered in 4 of the previous 10 games
• Over 46.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.00 pts and allowed 22.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.20 pts and allowed 23.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 49.90 pts in the previous 10 games
• Game Totals at Home: An average of 63.60 pts in the previous 10 home games
• Over 46.5: Covered in 6 of the previous 10 games
• Over 46.5 at Home: Covered in 9 of the previous 10 home games
• Team Totals: Have scored an average of 25.60 pts and allowed 24.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 32.10 pts and allowed 31.50 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Georgia Tech	5	0	185	106	79	3-0	2-0	5W
Louisville	4	0	153	75	78	3-0	1-0	4W
Miami	4	0	147	46	101	4-0	0-0	4W
California	4	1	124	90	34	2-0	2-1	1W
Virginia	4	1	228	116	112	4-0	0-1	3W
Florida State	3	1	212	76	136	3-0	0-1	1L
Syracuse	3	2	156	148	8	2-1	1-1	1L
NC State	3	2	147	140	7	2-1	1-1	2L
Duke	3	2	174	132	42	2-1	1-1	2W
North Carolina	2	2	84	91	-7	1-1	1-1	1L
Pittsburgh	2	2	157	91	66	2-1	0-1	2L
SMU	2	2	139	106	33	1-1	1-1	1L
Wake Forest	2	2	105	83	22	2-2	0-0	2L
Stanford	2	3	103	147	-44	2-0	0-3	1W
Virginia Tech	2	3	118	140	-22	1-2	1-1	2W
Boston College	1	3	150	110	40	1-1	0-2	3L
Clemson	1	3	79	91	-12	1-2	0-1	2L