Duke vs Clemson Prediction, Picks & Odds | 01 Nov 2025

College Football Betting Preview: Duke vs Clemson

Duke clash with Clemson in this NCAAF matchup at Memorial Stadium, with kickoff scheduled for 12:00 on Saturday 1 November. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Can Duke Make it a Close Game?

We wouldn’t be surprised to see Duke win and it makes sense to take +2.5 on the spread at -112 when they go up against Clemson.

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Duke Won 28-7 When Teams Last Met

Duke Blue Devils have claimed back-to-back road wins. In the previous game, they suffered a 27-18 home defeat against Georgia Tech Yellow Jackets at Wallace Wade Stadium.

Clemson Tigers lost their last game, being beaten at home to SMU Mustangs 35-24 at Memorial Stadium.

Head-to-Head Statistics

Duke beat Clemson in their last head-to-head matchup. It was a 28-7 scoreline at Wallace Wade Stadium.

Duke vs Clemson Prediction & Picks

Unlock a complete betting breakdown for Duke vs Clemson, featuring our expert match prediction, expected final score, standout player prop picks and a ready-to-play bet builder.

Game Prediction

We’ve lined up a pick which requires Duke to keep close to the favorites in this college football showdown. We think that the +2.5 betting line can be covered and you can secure -112.

Getting the lowdown on injuries and analyzing the form guide are key steps before making CFB predictions. We also put strong emphasis on stats, where a data-led approach often leads to smarter picks.

Key Duke vs Clemson stats:

• The +2.5 line has been covered by Duke in 14 of their last 20 games.
• The +2.5 line has been covered by Duke in 6 of their last 10 games.
• The +2.5 line has been covered by Duke in 2 consecutive games on the road.
• The -2.5 line hasn’t been covered by Clemson in 4 of their last 5 games at home.
• The -2.5 line hasn’t been covered by Clemson in 3 of their last 4 games at home this season.
• The -2.5 line hasn’t been covered by Clemson in 2 consecutive games at home.

Duke +2.5 Probability

Based on the odds from the top betting apps, our pick has a 52.9% chance of landing a return. Our analysts think there’s a stronger chance of success and calculate the probability to be 55-60%. This college bet can therefore be backed with confidence.

It’s possible to move the line for your point spread pick and this allows bettors to get increasingly bigger odds. Squeeze more juice from your selection by taking an alternative betting view.

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Best Bet

Duke +2.5 @ -112 Bet Now

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Player Prop Picks

Top Pick: Darian Mensah Over 272.5 Passing Yards -114

You can back Darian Mensah (Duke) at -114 to top 272.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.

Latest Darian Mensah Player Prop Odds

Passing Yards

Over 272.5

-114

Under 272.5

-114

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Que'Sean Brown Over 49.5 Receiving Yards -114

Que'Sean Brown (Duke) is available at -114 to go beyond over 49.5 receiving yards. We can place a Player Receiving Yards bet with confidence, as we expect him to cover the line.

Latest Que'Sean Brown Player Prop Odds

Receiving Yards

Over 49.5

-114

Under 49.5

-114

Correct Score Prediction

Duke 27 - 24 Clemson

We’re expecting this to be a close matchup and we’ll take Duke to win 27-24. This is available at massive odds for those that want to have a speculative wager.

Duke vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Game Could Go Right to the Wire According to the Books

We’re seeing Clemson priced up at -164 for a victory, with Duke trading at +138. The sportsbooks award a 42% probability that the road team will be settled as a winning bet.

The spread is calculated to be 3.5, while total points comes in at 54.5. There are many ways to wager on football including the Totals. There’s the chance to back Under 54.5 at -115.

Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.

Moneyline

Duke

+138

Clemson

-164

Point Spread

Duke +3.5

-110

Clemson -3.5

-110

Total Points

Under 54.5

-115

Over 54.5

-105

Player Odds

Receiving Yards

Cooper Barkate (Duke)

Over 71.5

-114

Under 71.5

-114

Que'Sean Brown (Duke)

Over 49.5

-114

Under 49.5

-114

Sahmir Hagans (Duke)

Over 39.5

-114

Under 39.5

-114

Rushing Yards

Nate Sheppard (Duke)

Over 59.5

-114

Under 59.5

-114

Clemson With Five Wins in Previous Ten Home Games

Clemson have gone 5-5 across their last 10 home games, averaging 31.50 points scored and 24.60 points allowed.

Duke have six wins and four losses in the last 10 games on the road, averaging 29.80 points scored and 26.00 points allowed.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Clemson Home Stats		5-5	56.10	31.50	24.60	5	5
Duke Away Stats		6-4	55.80	29.80	26.00	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Duke Blue Devils Stats

Clemson Tigers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 58.80 pts in the previous 10 games
• Game Totals on the Road: An average of 55.80 pts in the previous 10 games on the road
• Over 54.5: Covered in 7 of the previous 10 games
• Over 54.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.10 pts and allowed 27.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 29.80 pts and allowed 26.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.60 pts in the previous 10 games
• Game Totals at Home: An average of 56.10 pts in the previous 10 home games
• Over 54.5: Covered in 4 of the previous 10 games
• Over 54.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 25.40 pts and allowed 23.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.50 pts and allowed 24.60 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Georgia Tech	8	0	288	160	128	5-0	3-0	8W
Virginia	7	1	297	179	118	5-0	2-1	6W
Louisville	6	1	242	150	92	4-1	2-0	2W
Miami	6	1	238	99	139	5-1	1-0	1W
Pittsburgh	6	2	322	176	146	4-1	2-1	4W
Wake Forest	5	2	187	132	55	3-2	2-0	3W
California	5	3	200	195	5	3-1	2-2	1L
SMU	5	3	251	171	80	3-1	2-2	1L
Duke	4	3	237	180	57	2-2	2-1	1L
NC State	4	4	244	239	5	3-1	1-3	2L
Clemson	3	4	182	146	36	1-3	2-1	1L
Florida State	3	4	278	158	120	3-2	0-2	4L
Stanford	3	5	140	236	-96	3-0	0-5	1L
Syracuse	3	5	203	250	-47	2-2	1-3	4L
Virginia Tech	3	5	203	239	-36	2-3	1-2	1W
North Carolina	2	5	128	167	-39	1-3	1-2	4L
Boston College	1	7	214	275	-61	1-3	0-4	7L