Duke vs Clemson Prediction, Picks & Odds | 01 Nov 2025

College Football Betting Preview: Duke vs Clemson

Duke clash with Clemson in this NCAAF matchup at Memorial Stadium, with kickoff scheduled for 11:00 on Saturday, November 1. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We wouldn’t be surprised to see Duke win and it makes sense to take +2.5 on the spread at -112 when they go up against Clemson.

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Duke Blue Devils have claimed back-to-back road wins. In the previous game, they suffered a 27-18 home defeat against Georgia Tech Yellow Jackets at Wallace Wade Stadium.

Clemson Tigers lost their last game, being beaten at home to SMU Mustangs 35-24 at Memorial Stadium.

Head-to-Head Statistics

Duke beat Clemson in their last head-to-head matchup. It was a 28-7 scoreline at Wallace Wade Stadium.

Duke vs Clemson Prediction & Picks

Unlock a complete betting breakdown for Duke vs Clemson, featuring our expert match prediction, expected final score, standout player prop picks and a ready-to-play bet builder.

Game Prediction

We’ve lined up a pick which requires Duke to keep close to the favorites in this college football showdown. We think that the +2.5 betting line can be covered and you can secure -112.

Getting the lowdown on injuries and analyzing the form guide are key steps before making CFB predictions. We also put strong emphasis on stats, where a data-led approach often leads to smarter picks.

Key Duke vs Clemson stats:

• The +2.5 line has been covered by Duke in 14 of their last 20 games.
• The +2.5 line has been covered by Duke in 6 of their last 10 games.
• The +2.5 line has been covered by Duke in 2 consecutive games on the road.
• The -2.5 line hasn’t been covered by Clemson in 4 of their last 5 games at home.
• The -2.5 line hasn’t been covered by Clemson in 3 of their last 4 games at home this season.
• The -2.5 line hasn’t been covered by Clemson in 2 consecutive games at home.

Duke +2.5 Probability

Based on the odds from the top betting apps, our pick has a 52.9% chance of landing a return. Our analysts think there’s a stronger chance of success and calculate the probability to be 55-60%. This college bet can therefore be backed with confidence.

It’s possible to move the line for your point spread pick and this allows bettors to get increasingly bigger odds. Squeeze more juice from your selection by taking an alternative betting view.

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Our Game Prediction

Duke +2.5 @ -112 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (17:26, 30 October 2025). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Darian Mensah Over 272.5 Passing Yards -114

You can back Darian Mensah (Duke) at -114 to top 272.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.

Latest Darian Mensah Player Prop Odds

Passing Yards

Over 269.5

-114

Under 269.5

-114

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Que'Sean Brown Over 49.5 Receiving Yards -114

Que'Sean Brown (Duke) is available at -114 to go beyond over 49.5 receiving yards. We can place a Player Receiving Yards bet with confidence, as we expect him to cover the line.

Latest Que'Sean Brown Player Prop Odds

Receiving Yards

Over 44.5

-114

Under 44.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Duke 27 - 24 Clemson

We’re expecting this to be a close matchup and we’ll take Duke to win 27-24. This is available at massive odds for those that want to have a speculative wager.

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Duke vs Clemson Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

We’re seeing Clemson priced up at -172 for a victory, with Duke trading at +144. The sportsbooks award a 41% probability that the road team will be settled as a winning bet.

The spread is calculated to be 3.5, while total points comes in at 54.5. There are many ways to wager on football including the Totals. There’s the chance to back Under 54.5 at -102.

Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.

Moneyline

Duke

+144

Clemson

-172

Point Spread

Duke +3.5

-106

Clemson -3.5

-114

Total Points

Under 54.5

-102

Over 54.5

-120

Receiving Yards

Cooper Barkate (Duke)

Over 71.5

-114

Under 71.5

-114

Antonio Williams (Clemson)

Over 68.5

-114

Under 68.5

-114

T.J. Moore (Clemson)

Over 67.5

-114

Under 67.5

-114

Que'Sean Brown (Duke)

Over 44.5

-114

Under 44.5

-114

Sahmir Hagans (Duke)

Over 34.5

-112

Under 34.5

-112

Adam Randall (Clemson)

Over 21.5

-114

Under 21.5

-114

Rushing Yards

Adam Randall (Clemson)

Over 60.5

-114

Under 60.5

-114

Nate Sheppard (Duke)

Over 56.5

-114

Under 56.5

-114

Clemson With Five Wins in Previous Ten Home Games

Clemson have gone 5-5 across their last 10 home games, averaging 31.50 points scored and 24.60 points allowed.

Duke have six wins and four losses in the last 10 games on the road, averaging 29.80 points scored and 26.00 points allowed.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Clemson Home Stats		5-5	56.10	31.50	24.60	5	5
Duke Away Stats		6-4	55.80	29.80	26.00	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Latest regular season and playoff games stats.

Duke Blue Devils Stats

Clemson Tigers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 58.80 pts in the previous 10 games
• Game Totals on the Road: An average of 55.80 pts in the previous 10 games on the road
• Over 54.5: Covered in 7 of the previous 10 games
• Over 54.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.10 pts and allowed 27.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 29.80 pts and allowed 26.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.60 pts in the previous 10 games
• Game Totals at Home: An average of 56.10 pts in the previous 10 home games
• Over 54.5: Covered in 4 of the previous 10 games
• Over 54.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 25.40 pts and allowed 23.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.50 pts and allowed 24.60 pts in the last 10 home games

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