Duke vs North Carolina Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Duke vs North Carolina

Duke square off against North Carolina at Kenan Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.

Duke really stand out on the spread. Back them to get the better of North Carolina with the confidence that they can cover a more than generous -6.5 line at -120.

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Duke Blue Devils have been defeated in back-to-back games. They were recently beaten at home to Virginia Cavaliers by a 34-17 scoreline at Wallace Wade Stadium.

North Carolina Tar Heels lost on the road in their last game. Wake Forest won 28-12 at Allegacy Federal Credit Union Stadium.

Head-to-Head Statistics

The scoreline was 21-20 in favor of Duke when they last played North Carolina, with the matchup taking place at Wallace Wade Stadium. We’ve seen five North Carolina wins in the past 6 meetings between the teams.

Quarterbacks

Darian Mensah

268.5 Passing Yards

Over -114

Under -114

Gio Lopez

203.5 Passing Yards

Over -114

Under -114

Duke vs North Carolina Prediction & Picks

Explore our best Duke vs North Carolina picks, including our main match prediction, correct score forecast, player performance props and a bet builder ready to use.

Game Prediction

There’s a case for backing Duke against the spread in this college football battle. The line looks attractive considering you can get odds of -120 when it comes to the favorites at -6.5.

Sportsgambler.com brings strong college football expertise, built on knowing the team news as soon as it’s confirmed. Recent form plays a big part in our CFB picks and we always back it up with the most relevant stats.

Key Duke vs North Carolina stats:

• The +6.5 line hasn’t been covered by North Carolina in 5 of their last 10 games at home.

Duke -6.5 Probability

The top betting apps are suggesting that our pick has a 54.6% chance of delivering a return. In our opinion, there’s actually a probability of success closer to 60%. It is the reason why we are recommending this college wager.

Bettors can choose between buying or selling points depending on their attitude to risk. When you move the line in either direction, the odds change accordingly.

Before you place your bets, explore our updated guide packed with the latest free bets and betting bonuses.

Our Game Prediction

Duke -6.5 @ -120 Bet Now

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Player Prop Picks

Top Pick: Gio Lopez Under 203.5 Passing Yards -114

Gio Lopez (North Carolina) can be backed at -114 to record fewer than 203.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.

Latest Gio Lopez Player Prop Odds

Passing Yards

Over 203.5

-114

Under 203.5

-114

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Kobe Paysour Under 40.5 Receiving Yards -114

The odds for Kobe Paysour (North Carolina) to finish with fewer than 40.5 receiving yards stand at -114. He could struggle to reach the Player Receiving Yards line, making this prop bet highly appealing.

Latest Kobe Paysour Player Prop Odds

Receiving Yards

Over 40.5

-114

Under 40.5

-114

Correct Score Prediction

Duke 34 - 23 North Carolina

Let’s roll the dice and try Duke to achieve a 34-23 winning scoreline here. There are huge odds for this potential outcome and it’s a fun type of bet to enjoy.

Duke vs North Carolina Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The Duke odds have been priced up by the sportsbooks and they are -250 betting favorites to land victory in this college game which means a 71% chance of winning. At +205, North Carolina are regarded as having a lower probability of winning.

6.5 is the spread and 51.5 is the total points line. There is no denying the popularity of wagering on the Totals. Those who wager Under 51.5 can get -110.

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

Duke

-250

UNC

+205

Point Spread

Duke -6.5

-120

UNC +6.5

-102

Total Points

Under 51.5

-110

Over 51.5

-110

Receiving Yards

Cooper Barkate (Duke)

Over 72.5

-114

Under 72.5

-114

Que'Sean Brown (Duke)

Over 51.5

-114

Under 51.5

-114

Jordan Shipp (UNC)

Over 50.5

-114

Under 50.5

-114

Kobe Paysour (UNC)

Over 40.5

-114

Under 40.5

-114

Rushing Yards

Nate Sheppard (Duke)

Over 64.5

-114

Under 64.5

-114

Demon June (UNC)

Over 42.5

-114

Under 42.5

-114

Passing Yards

Darian Mensah (Duke)

Over 268.5

-114

Under 268.5

-114

Gio Lopez (UNC)

Over 203.5

-114

Under 203.5

-114

North Carolina Have Won the Previous Three Head-to-Head Matchups at Kenan Stadium

North Carolina have gone 3-7 across their last 10 home games, averaging 27.00 points scored and 32.80 points allowed.

Duke have five wins and five losses in the last 10 games away from home, averaging 30.70 points on offense and surrendering 30.50 on defense.

The previous meeting at Kenan Stadium saw North Carolina defeat Duke 47-45. In their past 3 head-to-heads at Kenan Stadium, North Carolina have won each one.

Last 10 Games		W-L	P	PF	PA	O51.5	U51.5
North Carolina Home Stats		3-7	59.80	27.00	32.80	6	4
Duke Away Stats		5-5	61.20	30.70	30.50	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O51.5 = Games Over 51.5 Points
• U51.5 = Games Under 51.5 Points

Latest regular season and playoff games stats.

Duke Blue Devils Stats

North Carolina Tar Heels Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -6.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -6.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +6.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +6.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 63.00 pts in the previous 10 games
• Game Totals on the Road: An average of 61.20 pts in the previous 10 games on the road
• Over 51.5: Covered in 7 of the previous 10 games
• Over 51.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 33.40 pts and allowed 29.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.70 pts and allowed 30.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 40.70 pts in the previous 10 games
• Game Totals at Home: An average of 51.90 pts in the previous 10 home games
• Over 51.5: Covered in 1 of the previous 10 games
• Over 51.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 18.70 pts and allowed 22.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 23.40 pts and allowed 28.50 pts in the last 10 home games

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