Florida State vs Clemson Prediction, Picks & Odds | 08 Nov 2025

College Football Betting Preview: Florida State vs Clemson

Florida State battle Clemson at Memorial Stadium, with kickoff scheduled for 19:00 on Saturday, November 8. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.

Clemson to Triumph?

It’s time to side with Clemson to record a victory over Florida State. They should have the upper hand and the -120 for our Moneyline prediction looks a good price.

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4 Victories for Clemson in Previous 5 H2H Games

Florida State Seminoles have lost their previous two on the road. Their most recent game was at home at Doak Campbell Stadium where they recorded a 42-7 victory over Wake Forest.

Clemson Tigers were beaten 46-45 at Memorial Stadium in their last game. This loss to Duke Blue Devils was their third straight home defeat.

Head-to-Head Statistics

Clemson won the most recent matchup between these teams. A 29-13 victory was registered against Florida State at Doak Campbell Stadium. Clemson have won four of the past 5 games that these teams have played.

Quarterbacks

Tommy Castellanos

239.5 Passing Yards

Over -114

Under -114

Cade Klubnik

288.5 Passing Yards

Over -114

Under -114

Florida State vs Clemson Prediction & Picks

We’ve lined up expert Florida State vs Clemson betting tips, from our match prediction and correct score call to player prop picks and best bet builder advice. Read on for the full breakdown.

Game Prediction

For this college football matchup, we are going to bet against Florida State with our pick. One way of doing this is by siding with the opposition and we really like the -120 about the home team winning on the Moneyline.

Our team of college football handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Florida State vs Clemson stats:

• Clemson have won 12 of their last 20 games at home.
• Florida State have lost their last 7 games on the road.
• Florida State have lost 14 of their last 20 games.
• Clemson have won 4 of their last 5 games against Florida State.

Clemson Moneyline Probability

Looking at the latest betting odds, our pick has a 54.6% chance of winning. In the opinion of our cappers, there’s actually a probability of success closer to 60%. It's why we think it’s worth placing this college wager.

You can choose an alternative if you want bigger odds about a victory for Clemson. The Double Result lines allow you to wager them to lead at the halfway stage too.

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Best Bet

Clemson Moneyline @ -120 Bet Now

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Player Prop Picks

Top Pick: Tommy Castellanos Under 239.5 Passing Yards -114

Tommy Castellanos (FSU) is priced at -114 to finish with fewer than 239.5 passing yards. He may fall short of the QB Passing Yards line, making this prop bet a strong pick.

Latest Tommy Castellanos Player Prop Odds

Passing Yards

Over 239.5

-114

Under 239.5

-114

Correct Score Prediction

Florida State 28 - 35 Clemson

A 35-28 win for Clemson is clearly a risky bet although this could be an exciting correct score option where there’s the chance to enjoy a massive potential return.

Florida State vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Moneyline Odds Suggest a Close-Run Battle

There’s the opportunity to back Clemson at -120 on the Moneyline although Florida State are priced up at betting odds of +102. According to the top sportsbooks, the home team have an implied probability of 55%.

The current spread is 1.5 and total points is 56.5. A wager on the Totals allows football bettors to use the latest data to good effect. Those expecting a low total can back Under 56.5 at -110.

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

FSU

+102

Clemson

-120

Point Spread

FSU +1.5

-110

Clemson -1.5

-110

Total Points

Under 56.5

-110

Over 56.5

-110

Player Odds

Passing Yards

Cade Klubnik (Clemson)

Over 288.5

-114

Under 288.5

-114

Tommy Castellanos (FSU)

Over 239.5

-114

Under 239.5

-114

Can Clemson Stop the Home Slide?

Clemson have been beaten three times in a row at Memorial Stadium. They are 4-6 in their last 10 home games, averaging 30.10 points on offense and surrendering 25.70 on defense.

Florida State have stumbled to seven straight defeats on the road. They have three wins and seven losses in the last 10 road games, averaging 21.00 points on offense and surrendering 28.10 on defense.

The last time these teams met at Memorial Stadium, FSU came out on top 31-24 against Clemson. Over the last 3 head-to-head clashes at Memorial Stadium, Clemson have recorded two wins, while FSU have one to their name.

Last 10 Games		W-L	P	PF	PA	O56.5	U56.5
Clemson Home Stats		4-6	55.80	30.10	25.70	4	6
Florida State Away Stats		3-7	49.10	21.00	28.10	3	7

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O56.5 = Games Over 56.5 Points
• U56.5 = Games Under 56.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Florida State Seminoles Stats

Clemson Tigers Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +1.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +1.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -1.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -1.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 57.50 pts in the previous 10 games
• Game Totals on the Road: An average of 49.10 pts in the previous 10 games on the road
• Over 56.5: Covered in 4 of the previous 10 games
• Over 56.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 37.20 pts and allowed 20.30 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.00 pts and allowed 28.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 54.60 pts in the previous 10 games
• Game Totals at Home: An average of 55.80 pts in the previous 10 home games
• Over 56.5: Covered in 4 of the previous 10 games
• Over 56.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 28.50 pts and allowed 26.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 30.10 pts and allowed 25.70 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Virginia	8	1	328	200	128	5-0	3-1	7W
Georgia Tech	8	1	324	208	116	5-0	3-1	1L
Louisville	7	1	270	166	104	4-1	3-0	3W
Pittsburgh	7	2	357	196	161	4-1	3-1	5W
Miami	6	2	258	125	133	5-1	1-1	1L
SMU	6	3	277	191	86	4-1	2-2	1W
Duke	5	3	283	225	58	2-2	3-1	1W
Wake Forest	5	3	194	174	20	3-2	2-1	1L
NC State	5	4	292	275	17	4-1	1-3	1W
California	5	4	221	226	-5	3-2	2-2	2L
Florida State	4	4	320	165	155	4-2	0-2	1W
Clemson	3	5	227	192	35	1-4	2-1	2L
North Carolina	3	5	155	177	-22	1-3	2-2	1W
Stanford	3	6	160	271	-111	3-1	0-5	2L
Virginia Tech	3	6	219	267	-48	2-4	1-2	1L
Syracuse	3	6	213	277	-64	2-3	1-3	5L
Boston College	1	8	224	300	-76	1-4	0-4	8L