Georgia Southern vs USC Prediction, Picks & Odds | 06 Sep 2025

College Football Betting Preview: Georgia Southern vs USC

Georgia Southern go up against USC in this NCAAF Week 2 matchup at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday, September 6. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Georgia Southern can give a good account of themselves against USC. They can prevent a big loss and there is -105 available that the underdogs cover the +28.5 spread.

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Georgia Southern Eagles suffered a defeat in their previous game. A 42-14 scoreline occurred on the road at Solider Field against Fresno State Bulldogs.

USC Trojans won their last game, beating Missouri State Bears at home. It was a 73-13 win at LA Memorial Coliseum.

Georgia Southern vs USC Prediction & Picks

We’ve lined up expert Georgia Southern vs USC betting tips, from our main match prediction and correct score call to bet builder advice. Read on for the full breakdown.

Game Prediction

We like the look of the underdogs +28.5 at odds of -105. We think Georgia Southern can take on the big favorites and put up a strong showing in this college football matchup.

Our CFB picks always start with checking the latest team news and understanding how it might impact the game. From there, we dive into the most valuable stats to uncover the insights that matter most.

Key Georgia Southern vs USC stats:

• The +28.5 line has been covered by Georgia Southern in 10 consecutive games.
• The +28.5 line has been covered by Georgia Southern in 19 of their last 20 games.
• The -28.5 line hasn’t been covered by USC in 9 of their last 10 games.
• The -28.5 line hasn’t been covered by USC in 18 of their last 20 games.

GA Southern +28.5 Probability

According to the best betting apps, there’s a 51.3% chance that our pick is settled as a winner. After careful examination, our analysts have this probability somewhere between 55-60%. It's why we think it’s worth placing this college wager.

If the initial odds don’t grab your fancy, there’s the alternative to shoot for more juice by moving the line when it comes to your pick. It all comes down to how confident you feel.

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Our Game Prediction

Georgia Southern +28.5 @ -105 Bet Now

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Correct Score Prediction

Georgia Southern 17 - 41 USC

Should you want a wager that can land a big return, then look no further than the correct score lines. Bet on the Trojans to win 41-17 and leverage a massive payout if this happens.

Georgia Southern vs USC Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks are taking no chances with their Moneyline odds of -10000 about USC which reflects they have a 99% chance of winning this college game. At +2000, Georgia Southern are regarded as having a lower probability of winning.

28.5 is the spread and 62.5 is the total points line. A Total bet relates to the number of points that will be scored overall. There’s the chance to back Under 62.5 at -110.

Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.

Moneyline

GA Southern

+2000

USC

-10000

Point Spread

GA Southern +28.5

-105

USC -28.5

-115

Total Points

Under 62.5

-110

Over 62.5

-110

Prop bets don’t involve betting on a team to win and instead might look at a player’s individual performance. For example, the number of Passing Yards a quarterback might have or the number of Touchdowns a player might score.

There are lots of exciting college football micro betting lines that are created and they are available in-game. Among them are whether a field goal will be scored and you simply bet whether the player will make it or miss.

USC Have Collected Six Wins in Past Ten Home Games

USC have six wins and four losses in the last 10 home games, scoring 39.80 points per contest and conceding 27.40.

Georgia Southern have four wins and six losses in the last 10 games on the road, scoring 23.80 points per contest and conceding 34.20.

Last 10 Games		W-L	P	PF	PA	O60.5	U60.5
USC Home Stats		6-4	67.20	39.80	27.40	6	4
Georgia Southern Away Stats		4-6	58.00	23.80	34.20	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O60.5 = Games Over 60.5 Points
• U60.5 = Games Under 60.5 Points

Latest regular season and playoff games stats.

Georgia Southern Eagles Stats

USC Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +28.5 Betting Line: Have covered the spread in the last 10 games
• +28.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -28.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -28.5 Betting Line at Home: Have covered the spread in 2 of the last 10 home games

Total Points

• Game Totals: An average of 52.00 pts in the previous 10 games
• Game Totals on the Road: An average of 58.00 pts in the previous 10 games on the road
• Over 60.5: Covered in 2 of the previous 10 games
• Over 60.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.80 pts and allowed 26.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 23.80 pts and allowed 34.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.60 pts in the previous 10 games
• Game Totals at Home: An average of 64.40 pts in the previous 10 home games
• Over 60.5: Covered in 5 of the previous 10 games
• Over 60.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 32.80 pts and allowed 25.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 39.10 pts and allowed 25.30 pts in the last 10 home games

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