Indiana vs Iowa Prediction, Picks & Odds | 27 Sep 2025

By Patrick Jones, NCAAF Analyst | Published: 16 hours ago | 4 min read

Indiana Hoosiers

American Football NCAAF Kinnick Stadium Sat 27 Sep 15:30

Iowa Hawkeyes

Prediction
Bet Builder
Odds
Player Props
Stats
Standings

College Football Betting Preview: Indiana vs Iowa

Indiana face Iowa in this NCAAF Week 5 matchup at Kinnick Stadium, with kickoff scheduled for 15:30 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Iowa to Make Life Tough for Indiana

There’s a good opportunity to back Iowa against the spread considering the underdogs should perform well against Indiana. Snap up the -100 when it comes to them covering the +7.5.

Rolling with our spread angle? Snag our exclusive BetMGM promo code and read the in-depth review of the sportsbook before you commit to your play.

Iowa Claimed 34-6 Victory in Last H2H

Indiana Hoosiers beat Illinois Fighting Illini in their previous game, making it four straight victories. It was a 63-10 home win at Memorial Stadium.

Iowa Hawkeyes won last time out by a 38-28 scoreline. On the road against Rutgers Scarlet Knights at SHI Stadium, they made it back-to-back wins.

Head-to-Head Statistics

It was Iowa who came out on top when they last played Indiana. At Kinnick Stadium, a 34-6 win was recorded.

Quarterbacks

Fernando Mendoza

Mark Gronowski

Indiana vs Iowa Prediction & Picks

The Indiana vs Iowa betting tips feature sharp analysis across major markets, including a key match prediction, player prop bets, correct score guidance and a ready-made bet builder.

Game Prediction

We’re happy to get with Iowa against the spread in this college football matchup. -100 is available that they are able to cover +7.5 and that looks more than reasonable.

Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.

Key Indiana vs Iowa stats:

The +7.5 line has been covered by Iowa in 10 consecutive games.
The +7.5 line has been covered by Iowa in 19 of their last 20 games at home.
The -7.5 line hasn’t been covered by Indiana in 16 of their last 20 games on the road.
The -7.5 line hasn’t been covered by Indiana in 7 of their last 10 games on the road.
The -7.5 line hasn’t been covered by Indiana in 2 consecutive games on the road.

Iowa +7.5 Probability

The top betting apps make it a 50% chance that our pick is settled as a winner. Based on our in-depth research, we calculate the actual probability to be closer to 60%. That means we’re regarding it as a value bet.

Looking for Bigger Odds?

If you want to back Iowa without taking them on the point spread, there’s the alternative to go for a Winning Margin wager instead. There are lots of different options here.

Before placing your next bet, explore our complete guide to the best betting offers, promotions and welcome bonuses today.

Best Bet

Iowa +7.5 @ -100 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Published 22:26, 25 September 2025

Player Prop Picks

Top Pick: Fernando Mendoza Under 250.5 Passing Yards -114

The odds for Fernando Mendoza (Indiana) to end with fewer than 250.5 passing yards are -114. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Fernando Mendoza Player Prop Odds

Touchdown

Passing Yards

E.J. Williams Jr. Under 29.5 Receiving Yards -114

E.J. Williams Jr. (Iowa) can be backed at -114 to record fewer than 29.5 receiving yards. We’re confident he’ll fall short of the Player Receiving Yards line, as the total looks too high.

Latest E.J. Williams Jr. Player Prop Odds

Touchdown

Receiving Yards

Same Game Parlay Picks

Spread Iowa +7.5

Totals Over 48.5

Passing Yards Fernando Mendoza Under 250.5

Try out our same game parlay pick which starts with Iowa +7.5. We’ve also gone for Over 48.5 points and Fernando Mendoza (Indiana) to have Under 250.5 passing yards.

A same game parlay is a fantastic option for bettors who want to focus their wagering on a single football game. You can predict different outcomes and see their odds combined before going ahead and placing this tailored bet.

Bet Boosts

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Indiana

28 - 24 Iowa logo

Iowa

There might not be too much between these teams, with our correct score pick being a 28-24 victory for the Hoosiers. There are huge odds available when it comes to this prediction.

Indiana vs Iowa Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Indiana Likely to Win According to Latest Odds

Indiana have the shortest price to win this college game, with the sportsbooks giving them a 76% probability due to their -313 Moneyline betting odds. For those wanting to back Iowa, you will find +250 about the underdogs.

There is a spread of 7.5 and total points has a line of 48.5. Football fans love the chance to get an alternative angle by going for a Total wager. Those expecting a low total can back Under 48.5 at -115.

The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.

Moneyline

Point Spread

Total Points

Elijah Sarratt Favorite to Score First Touchdown

The Anytime Touchdown betting indicates that Elijah Sarratt has odds of %anytime_odds%. He is available at %first_odds% to score the first TD which makes him favorite.

Touchdown

Elijah Sarratt (Indiana)

Omar Cooper Jr. (Indiana)

Mark Gronowski (Iowa)

Roman Hemby (Indiana)

View More View Less

Receiving Yards

Elijah Sarratt (Indiana)

Omar Cooper Jr. (Indiana)

E.J. Williams Jr. (Indiana)

Roman Hemby (Indiana)

Rushing Yards

Roman Hemby (Indiana)

Kaelon Black (Indiana)

Mark Gronowski (Iowa)

Passing Yards

Fernando Mendoza (Indiana)

Mark Gronowski (Iowa)

Best Betting Offers

Kinnick Stadium

Iowa Rolling at Home

Iowa have rattled off seven straight wins at Kinnick Stadium. They have eight wins and two losses in the last 10 games at home, averaging 31.30 points scored and 13.10 points allowed.

Indiana have three wins and seven losses in the last 10 games on the road, averaging 28.60 points scored and 32.40 points allowed.

Iowa beat Indiana 34-6 when they last met at Kinnick Stadium.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Iowa Home Stats		8-2	44.40	31.30	13.10	5	5
Indiana Away Stats		3-7	61.00	28.60	32.40	9	1

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O48.5 = Games Over 48.5 Points
U48.5 = Games Under 48.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Indiana

NCAAF: 21/09 Illinois10 Indiana 63
NCAAF: 13/09 Indiana State0 Indiana 73
NCAAF: 06/09 Kennesaw State9 Indiana 56
NCAAF: 30/08 Old Dominion14 Indiana 27
NCAAF National Championship: 21/12 Indiana17 Notre Dame 27

Iowa

NCAAF: 20/09 Iowa38 Rutgers 28
NCAAF: 14/09 Massachusetts7 Iowa 47
NCAAF: 06/09 Iowa13 Iowa State 16
NCAAF: 31/08 Albany7 Iowa 34
NCAAF Bowls: 30/12 Iowa24 Missouri 27

Head to Head

Indiana vs Iowa

NCAAF: 04/09 2021 Indiana 6 Iowa 34

Team Stats

Latest regular season and playoff games stats.

Indiana Hoosiers Stats

Iowa Hawkeyes Stats

Moneyline

8 wins and 2 defeats in the last 10 games
3 wins and 7 defeats in the last 10 games on the road

Moneyline

7 wins and 3 defeats in the last 10 games
8 wins and 2 defeats in the last 10 home games

Point Spread

-7.5 Betting Line: Have covered the spread in 7 of the last 10 games
-7.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

+7.5 Betting Line: Have covered the spread in the last 10 games
+7.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games

Total Points

Game Totals: An average of 55.50 pts in the previous 10 games
Game Totals on the Road: An average of 61.00 pts in the previous 10 games on the road
Over 48.5: Covered in 6 of the previous 10 games
Over 48.5 on the Road: Covered in 9 of the previous 10 games on the road
Team Totals: Have scored an average of 41.50 pts and allowed 14.00 pts in the last 10 games
Team Totals on the Road: Have scored an average of 28.60 pts and allowed 32.40 pts in the last 10 games on the road

Total Points

Game Totals: An average of 44.90 pts in the previous 10 games
Game Totals at Home: An average of 44.40 pts in the previous 10 home games
Over 48.5: Covered in 5 of the previous 10 games
Over 48.5 at Home: Covered in 5 of the previous 10 home games
Team Totals: Have scored an average of 29.70 pts and allowed 15.20 pts in the last 10 games
Team Totals at Home: Have scored an average of 31.30 pts and allowed 13.10 pts in the last 10 home games

NCAAF Standings Select Season

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	4	0	219	33	186	4-0	0-0	4W
Maryland	4	0	130	43	87	3-0	1-0	4W
Ohio State	3	0	121	16	105	3-0	0-0	3W
Oregon	4	0	203	37	166	3-0	1-0	4W
Penn State	3	0	132	17	115	3-0	0-0	3W
USC	4	0	210	81	129	3-0	1-0	4W
Washington	3	0	167	55	112	2-0	1-0	3W
Rutgers	3	1	167	96	71	3-1	0-0	1L
Nebraska	3	1	174	54	120	2-1	1-0	1L
Michigan State	3	1	137	115	22	3-0	0-1	1L
Michigan	3	1	140	71	69	2-0	1-1	2W
Iowa	3	1	132	58	74	2-0	1-1	2W
Illinois	3	1	145	85	60	2-0	1-1	1L
Minnesota	2	1	103	37	66	2-0	0-1	1L
Purdue	2	2	112	106	6	2-1	0-1	2L
Wisconsin	2	2	83	75	8	2-1	0-1	2L
Northwestern	1	2	59	64	-5	1-1	0-1	1L
UCLA	0	3	43	108	-65	0-2	0-1	3L