Iowa vs USC Prediction, Picks & Odds | 15 Nov 2025
College Football Betting Preview: Iowa vs USC
Iowa face USC at LA Memorial Coliseum, with kickoff scheduled for 15:30 on Saturday, November 15.
Bet on USC against the spread, with an attractive line of -7.5 that they have the upper hand against Iowa. There are odds of -104 that are currently on offer for this selection.
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Iowa Hawkeyes have claimed back-to-back road wins. In the previous game, they suffered a 18-16 home defeat against Oregon Ducks at Kinnick Stadium.
USC Trojans have enjoyed five consecutive home wins at LA Memorial Coliseum. Last time out, Northwestern Wildcats were beaten 38-17.
Head-to-Head Statistics
Iowa won the most recent matchup between these teams. A 49-24 victory was registered against USC at San Diego Stadium.
Quarterbacks
Mark Gronowski
Jayden Maiava
Iowa vs USC Prediction & Picks
Our Iowa vs USC betting outlook has it all, including a trusted match forecast, our predicted score, top player prop picks and a hand-picked bet builder.
Game Prediction
The favorites really stand out in this college football matchup. Back USC against the spread with the confidence that they can cover a -7.5 line at odds of -104.
We’re always on top of team news and when combined with recent form, it helps us uncover the best value. Our college football handicappers also take a data-led approach, using key stats to back every pick.
Key Iowa vs USC stats:
USC -7.5 Probability
According to the top sportsbooks, our pick has a 51% chance of delivering a return. However, our cappers have this figure closer to 60% based on their in-depth research. The wager can be recommended for this precise reason.
If you want bigger odds, then you can move the line by selling points. Choose how many points to sell until you are happy with the juice available.
Boost your betting strategy with exclusive offers, free bets, and welcome bonuses—all in our straightforward guide.
Player Prop Picks
Mark Gronowski (Iowa) is available at -114 to have less than 140.5 passing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the QB Passing Yards line.
Makai Lemon (Iowa) can be backed at -114 to end with fewer than 89.5 receiving yards. He is likely to fall short of the line, making this Player Receiving Yards bet an appealing option.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are USC to cover the -7.5 spread, Over 48.5 on the total and Mark Gronowski (Iowa) to go Under 140.5 passing yards.
There are many options when you place a same game parlay. You can go through the football lines and identify your favorite outcomes before combining the odds on the bet slip. Personalised betting doesn’t come any better.
Correct Score Prediction
21
-
34
USC
Let’s roll the dice and try the Trojans to achieve a 34-21 winning scoreline here. There are huge odds for this potential outcome and it’s a fun type of bet to enjoy.
Iowa vs USC Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Sportsbooks’ favorites USC are regarded as likeliest victors for this college game and the -238 about them triumphing means a 70% chance based on their current Moneyline betting odds. If you’re looking for an alternative angle, Iowa are trading at +198.
There is a spread of 6.5 and total points has a line of 48.5. Having a bet on the Totals is one of the most popular football wagers. If you fancy Under 48.5, then the odds are -110.
The best betting apps offer a wide range of game lines and team props when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.
The First TD Scorer favorite is King Miller at +360. Similar odds can be found if you’re interested in this player to record the last touchdown.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Among the various options for wagering on college football, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as whether a touchdown will be scored within the next few minutes.
Can USC Keep Rolling at Home?
USC have strung together five in a row at LA Memorial Coliseum. They have a 8-2 record in their last 10 home games, putting up 41.90 points per contest and giving up 23.70.
Iowa have gone 4-6 across their last 10 games on the road, putting up 21.60 points per contest and giving up 22.00.
| Last 10 Games | W-L | P | PF | PA | O48.5 | U48.5 | |
|---|---|---|---|---|---|---|---|
 USC Home Stats |
8-2 | 65.60 | 41.90 | 23.70 | 8 | 2 | |
 Iowa Away Stats |
4-6 | 43.60 | 21.60 | 22.00 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O48.5 = Games Over 48.5 Points
- U48.5 = Games Under 48.5 Points
Latest regular season and playoff games stats.
Iowa Hawkeyes Stats
USC Stats
- 6 wins and 4 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +7.5 Betting Line: Have covered the spread in the last 10 games
- +7.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -7.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -7.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 44.00 pts in the previous 10 games
- Game Totals on the Road: An average of 43.60 pts in the previous 10 games on the road
- Over 48.5: Covered in 4 of the previous 10 games
- Over 48.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 29.00 pts and allowed 15.00 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 21.60 pts and allowed 22.00 pts in the last 10 games on the road
- Game Totals: An average of 61.80 pts in the previous 10 games
- Game Totals at Home: An average of 66.30 pts in the previous 10 home games
- Over 48.5: Covered in 8 of the previous 10 games
- Over 48.5 at Home: Covered in 8 of the previous 10 home games
- Team Totals: Have scored an average of 39.10 pts and allowed 22.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 41.60 pts and allowed 24.70 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
12 | 0 | 532 | 131 | 401 | 7-0 | 5-0 | 12W |
Ohio State
|
12 | 0 | 444 | 93 | 351 | 7-0 | 5-0 | 12W |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
|
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
|
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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