Kentucky vs Louisville Prediction, Picks & Odds | 29 Nov 2025

College Football Betting Preview: Kentucky vs Louisville

Kentucky battle Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 12:00 on Saturday, November 29.

It’s great to see Louisville with a -2.5 line on the spread at -122 as we’re expecting a bigger margin of victory when playing Kentucky.

Confident in our spread pick? Read the full review of BetMGM, then grab our exclusive promo code before placing your bet.

Kentucky Wildcats lost on the road in their previous game. Vanderbilt Commodores won 45-17 at FirstBank Stadium.

Louisville Cardinals lost on the road in their last game, making it three straight defeats. SMU Mustangs won 38-6 at Gerald J. Ford Stadium.

Head-to-Head Statistics

Louisville beat Kentucky when the teams last met. It was a 41-14 scoreline at Kroger Field. In the past 5 games between the teams, Kentucky have won four.

Kentucky vs Louisville Prediction & Picks

Our expert Kentucky vs Louisville betting tips include a main match prediction, a correct score pick and bet builder advice. Explore each section below for detailed insights.

Game Prediction

The best pick is to snap up the -122 that Louisville are able to cover the spread. The favorites are -2.5 for this college football showdown and the margin of victory could be a good deal more significant.

Our CFB predictions are rooted in solid team news and up-to-date form for each team. We also dig deep to uncover the most relevant stats that help guide and strengthen our picks.

Key Kentucky vs Louisville stats:

• The -2.5 line has been covered by Louisville in 14 of their last 20 games at home.
• The -2.5 line has been covered by Louisville in 7 of their last 11 games this season.
• The +2.5 line hasn’t been covered by Kentucky in 4 of their last 5 games on the road.
• The +2.5 line hasn’t been covered by Kentucky in 3 of their last 4 games on the road this season.

Louisville -2.5 Probability

The best betting apps imply that our pick has a 54.9% chance of winning. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It is the reason why we are recommending this college wager.

If you’re looking for an option to wagering Louisville on the spread, then consider the Winning Margin lines. You can choose from a wide range of fixed intervals and prices.

Before placing your bets, take advantage of our guide packed with up-to-date free bets and the latest bonus offers.

Our Game Prediction

Louisville -2.5 @ -122 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Correct Score Prediction

Kentucky 21 - 28 Louisville

If you want to take a chance on a correct score, then Louisville to achieve a 28-21 win could be along the right lines. There are huge odds for this particular outcome.

Kentucky vs Louisville Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The Louisville odds have been priced up by the sportsbooks and they are -152 betting favorites to land victory in this college game which means a 60% chance of winning. At +128, Kentucky are regarded as having a lower probability of winning.

2.5 is the spread and 45.5 is the total points line. A wager on the Totals allows football bettors to use the latest data to good effect. If you want to bet Under 45.5, there are odds of -108.

Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.

Moneyline

Kentucky

+128

Louisville

-152

Point Spread

Kentucky +2.5

-100

Louisville -2.5

-122

Total Points

Under 45.5

-108

Over 45.5

-112

The best gambling sites offer quarterback and player prop betting to their customers. These can be a great alternative if you want to focus on an individual’s performance within a game and it often involves wagering over or under a line.

It’s good to consider all wagering options when it comes to college football and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.

Louisville Standing on Five Wins From Last Ten Home Matches

Louisville own a 5-5 mark in their past 10 home games, putting up 33.80 points on average and giving up 24.60.

Kentucky own a 3-7 mark in their past 10 road games, averaging 17.80 points on offense and surrendering 29.00 on defense.

The last L&N Federal Credit Union Stadium meeting saw Kentucky beat Louisville 38-31.

Last 10 Games		W-L	P	PF	PA	O45.5	U45.5
Louisville Home Stats		5-5	58.40	33.80	24.60	8	2
Kentucky Away Stats		3-7	46.80	17.80	29.00	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O45.5 = Games Over 45.5 Points
• U45.5 = Games Under 45.5 Points

Latest regular season and playoff games stats.

Kentucky Wildcats Stats

Louisville Cardinals Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 51.20 pts in the previous 10 games
• Game Totals on the Road: An average of 46.80 pts in the previous 10 games on the road
• Over 45.5: Covered in 7 of the previous 10 games
• Over 45.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 25.20 pts and allowed 26.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.80 pts and allowed 29.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 50.60 pts in the previous 10 games
• Game Totals at Home: An average of 58.40 pts in the previous 10 home games
• Over 45.5: Covered in 5 of the previous 10 games
• Over 45.5 at Home: Covered in 8 of the previous 10 home games
• Team Totals: Have scored an average of 27.00 pts and allowed 23.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 33.80 pts and allowed 24.60 pts in the last 10 home games

Top American Football Pages