Kentucky vs Louisville Prediction, Picks & Odds | 29 Nov 2025
College Football Betting Preview: Kentucky vs Louisville
Kentucky battle Louisville at L&N Federal Credit Union Stadium, with kickoff scheduled for 12:00 on Saturday, November 29.
It’s great to see Louisville with a -2.5 line on the spread at -122 as we’re expecting a bigger margin of victory when playing Kentucky.
Confident in our spread pick? Read the full review of BetMGM, then grab our exclusive promo code before placing your bet.
Kentucky Wildcats lost on the road in their previous game. Vanderbilt Commodores won 45-17 at FirstBank Stadium.
Louisville Cardinals lost on the road in their last game, making it three straight defeats. SMU Mustangs won 38-6 at Gerald J. Ford Stadium.
Head-to-Head Statistics
Louisville beat Kentucky when the teams last met. It was a 41-14 scoreline at Kroger Field. In the past 5 games between the teams, Kentucky have won four.
Kentucky vs Louisville Prediction & Picks
Tackle Kentucky vs Louisville with all the betting insight you need, including our match prediction, scoreline forecast, key player prop selections and a hand-picked bet builder.
Game Prediction
The best pick is to snap up the -122 that Louisville are able to cover the spread. The favorites are -2.5 for this college football showdown and the margin of victory could be a good deal more significant.
Our CFB predictions are rooted in solid team news and up-to-date form for each team. We also dig deep to uncover the most relevant stats that help guide and strengthen our picks.
Key Kentucky vs Louisville stats:
Louisville -2.5 Probability
The best betting apps imply that our pick has a 54.9% chance of winning. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It is the reason why we are recommending this college wager.
If you’re looking for an option to wagering Louisville on the spread, then consider the Winning Margin lines. You can choose from a wide range of fixed intervals and prices.
Before placing your bets, take advantage of our guide packed with up-to-date free bets and the latest bonus offers.
Player Prop Picks
You can place a bet on Cutter Boley (Kentucky) at -114 to end with fewer than 207.5 passing yards. We're confident he’ll fall short of the QB Passing Yards line, so we're backing the Under.
Willie Rodriguez (Kentucky) is available at -114 to end with fewer than 27.5 receiving yards. If you agree with our verdict that the line is too high, this Player Receiving Yards wager is worth backing.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Louisville -2.5 on the spread, combined with Over 45.5 and Cutter Boley (Kentucky) to go Under 207.5 passing yards.
We recommend a same game parlay as it’s a great way of betting on a single event. Many football bettors like to create a personalised wager which reflects their predictions for how a game is going to play out.
Correct Score Prediction
21
-
28
Louisville
If you want to take a chance on a correct score, then Louisville to achieve a 28-21 win could be along the right lines. There are huge odds for this particular outcome.
Kentucky vs Louisville Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
The Louisville odds have been priced up by the sportsbooks and they are -118 betting favorites to land victory in this college game which means a 54% chance of winning. At -100, Kentucky are regarded as having a lower probability of winning.
1.5 is the spread and 46.5 is the total points line. A wager on the Totals allows football bettors to use the latest data to good effect. If you want to bet Under 46.5, there are odds of -105.
Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.
Seth McGowan is available at -135 when it comes to Anytime Touchdown Scorer. The favorite is now priced at odds of +480 to score the first TD.
Touchdown
Receiving Yards
Rushing Yards
It’s good to consider all wagering options when it comes to college football and micro betting can be an exciting way to get involved in the action. When everything goes in-game, consider whether a player will make or miss a field goal.
Louisville Standing on Five Wins From Last Ten Home Matches
Louisville own a 5-5 mark in their past 10 home games, putting up 33.80 points on average and giving up 24.60.
Kentucky own a 3-7 mark in their past 10 road games, averaging 17.80 points on offense and surrendering 29.00 on defense.
The last L&N Federal Credit Union Stadium meeting saw Kentucky beat Louisville 38-31.
| Last 10 Games | W-L | P | PF | PA | O45.5 | U45.5 | |
|---|---|---|---|---|---|---|---|
 Louisville Home Stats |
5-5 | 58.40 | 33.80 | 24.60 | 8 | 2 | |
 Kentucky Away Stats |
3-7 | 46.80 | 17.80 | 29.00 | 6 | 4 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O45.5 = Games Over 45.5 Points
- U45.5 = Games Under 45.5 Points
Latest regular season and playoff games stats.
Kentucky Wildcats Stats
Louisville Cardinals Stats
- 4 wins and 6 defeats in the last 10 games
- 3 wins and 7 defeats in the last 10 games on the road
- +2.5 Betting Line: Have covered the spread in 4 of the last 10 games
- +2.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road
- -2.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 51.20 pts in the previous 10 games
- Game Totals on the Road: An average of 46.80 pts in the previous 10 games on the road
- Over 45.5: Covered in 7 of the previous 10 games
- Over 45.5 on the Road: Covered in 6 of the previous 10 games on the road
- Team Totals: Have scored an average of 25.20 pts and allowed 26.00 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 17.80 pts and allowed 29.00 pts in the last 10 games on the road
- Game Totals: An average of 50.60 pts in the previous 10 games
- Game Totals at Home: An average of 58.40 pts in the previous 10 home games
- Over 45.5: Covered in 5 of the previous 10 games
- Over 45.5 at Home: Covered in 8 of the previous 10 home games
- Team Totals: Have scored an average of 27.00 pts and allowed 23.60 pts in the last 10 games
- Team Totals at Home: Have scored an average of 33.80 pts and allowed 24.60 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
|
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
| Southeastern | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Georgia
|
12 | 1 | 415 | 207 | 208 | 6-1 | 6-0 | 9W |
Ole Miss
|
11 | 1 | 447 | 241 | 206 | 8-0 | 3-1 | 5W |
Texas A&M
|
11 | 1 | 436 | 263 | 173 | 7-0 | 4-1 | 1L |
Oklahoma
|
10 | 2 | 317 | 167 | 150 | 6-1 | 4-1 | 4W |
Vanderbilt
|
10 | 2 | 473 | 263 | 210 | 7-0 | 3-2 | 3W |
Alabama
|
10 | 3 | 406 | 226 | 180 | 6-2 | 4-1 | 1L |
Texas
|
9 | 3 | 355 | 237 | 118 | 7-0 | 2-3 | 2W |
Missouri
|
8 | 4 | 386 | 233 | 153 | 6-2 | 2-2 | 1W |
Tennessee
|
8 | 4 | 489 | 345 | 144 | 5-3 | 3-1 | 1L |
LSU
|
7 | 5 | 262 | 220 | 42 | 6-1 | 1-4 | 1L |
|
Kentucky
|
5 | 7 | 276 | 317 | -41 | 4-3 | 1-4 | 2L |
Auburn
|
5 | 7 | 321 | 248 | 73 | 3-4 | 2-3 | 1L |
Mississippi State
|
5 | 7 | 366 | 350 | 16 | 3-4 | 2-3 | 3L |
Florida
|
4 | 8 | 259 | 288 | -29 | 4-3 | 0-5 | 1W |
South Carolina
|
4 | 8 | 272 | 265 | 7 | 4-4 | 0-4 | 1L |
Arkansas
|
2 | 10 | 395 | 406 | -11 | 2-5 | 0-5 | 10L |
Green Bay
Youngstown State
Predictions
18:30 - Thu 22 Jan
NCAAB
Louisiana
Appalachian State
Predictions
Thursday
NBA
Denver Nuggets
Washington Wizards
Predictions
Thursday
NBA
Charlotte Hornets
Orlando Magic
Predictions
Thursday
NBA
Houston Rockets
Philadelphia 76ers
Predictions
19:00 - Thu 22 Jan
NCAAB
South Florida
UAB
Predictions