LSU vs Clemson Prediction, Picks & Odds | 30 Aug 2025

College Football Betting Preview: LSU vs Clemson

LSU meet Clemson in this NCAAF Week 1 matchup at Memorial Stadium, with kickoff scheduled for 19:30 on Saturday 30 August 2025. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

The Value Lies With Clemson

Clemson should be taken against the spread at -3.5 with our prediction being for the favorites to achieve a comfortable margin of victory in their meeting with LSU. Back them at the odds of -118 that are available.

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LSU Beat Clemson in their Last Matchup

LSU Tigers won their previous game, beating Baylor Bears. It was a 44-31 win at NRG Stadium.

Clemson Tigers were beaten last game and this was on the road at DKR-Texas Memorial Stadium. Texas Longhorns claimed a 38-24 win.

Head-to-Head Statistics

The last head-to-head saw LSU claim a 42-25 win over Clemson at Caesars Superdome.

Quarterbacks

Garrett Nussmeier

286.5 Passing Yards

Over -114

Under -114

Cade Klubnik

260.5 Passing Yards

Over -114

Under -114

LSU vs Clemson Prediction & Picks

Get the edge with our best LSU vs Clemson tips: a key match prediction, correct score recommendation, top player prop bets and a ready-made bet builder.

Game Prediction

Bet on Clemson against the spread, with an attractive line of -3.5 that the favorites get the job done. There are odds of -118 that are currently on offer for this college football matchup.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant stats, this gives us a strong foundation for accurate CFB picks.

Key LSU vs Clemson stats:

• The -3.5 line has been covered by Clemson in 8 of their last 10 games at home.
• The -3.5 line has been covered by Clemson in 15 of their last 20 games at home.
• The +3.5 line hasn’t been covered by LSU in 3 of their last 5 games on the road.
• The +3.5 line hasn’t been covered by LSU in 11 of their last 20 games on the road.
• The +3.5 line hasn’t been covered by LSU in 2 consecutive games on the road.

Clemson -3.5 Probability

According to the best betting apps, there’s a 54.1% chance that our pick is settled as a winner. After careful examination, our cappers have this probability close to 60%. This is why we can recommend this college wager.

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Best Bet

Clemson -3.5 @ -118 Bet Now

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Player Prop Picks

Garrett Nussmeier Under 290.5 Passing Yards -114

You can back Garrett Nussmeier (LSU) at -114 to record fewer than 290.5 passing yards. He could struggle to reach the QB Passing Yards line, making this prop bet highly appealing.

Latest Garrett Nussmeier Player Prop Odds

Passing Yards

Over 286.5

-114

Under 286.5

-114

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Caden Durham Under 62.5 Rushing Yards --100

You can place a bet on Caden Durham (Clemson) at --100 to have less than 62.5 rushing yards. He may fall short of the Player Rushing Yards line, making this prop bet a strong pick.

Latest Caden Durham Player Prop Odds

Receiving Yards

Over 17.5

-114

Under 17.5

-114

Rushing Yards

Over 62.5

-114

Under 62.5

-114

Correct Score Prediction

LSU 23 - 31 Clemson

There’s the chance to back Clemson in lots of different ways and this includes predicting the correct winning score. We’ll go for a 31-23 triumph in their favor.

LSU vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Clemson Favorites to Win According to the Books

The sportsbooks have Clemson at -185 when it comes to the Moneyline betting, implying the market leaders are 65% likely to win this college game according to the latest odds. LSU are the underdogs at +152 and they’re regarded as least likely to win.

The current spread is 3.5 and total points is 57.5. A Total wager is always available and can often provide value selections. If you’re going for Under 57.5, this outcome can be backed at -110.

The top sportsbooks cover every college football matchup with a great mix of game lines and team props. Whether you prefer to bet before kickoff or during the action, make sure to explore all available options.

Moneyline

LSU

+152

Clemson

-185

Point Spread

LSU +3.5

-104

Clemson -3.5

-118

Total Points

Under 57.5

-110

Over 57.5

-110

Player Odds

Receiving Yards

Aaron Anderson (LSU)

Over 63.5

-114

Under 63.5

-114

Antonio Williams (Clemson)

Over 61.5

-114

Under 61.5

-114

Bryant Wesco Jr. (Clemson)

Over 54.5

-114

Under 54.5

-114

Barion Brown (LSU)

Over 44.5

-114

Under 44.5

-114

Trey'Dez Green (LSU)

Over 25.5

-114

Under 25.5

-114

Adam Randall (Clemson)

Over 17.5

-114

Under 17.5

-114

Caden Durham (LSU)

Over 17.5

-114

Under 17.5

-114

Rushing Yards

Adam Randall (Clemson)

Over 66.5

-114

Under 66.5

-114

Caden Durham (LSU)

Over 62.5

-114

Under 62.5

-114

Cade Klubnik (Clemson)

Over 34.5

-114

Under 34.5

-114

Passing Yards

Garrett Nussmeier (LSU)

Over 286.5

-114

Under 286.5

-114

Cade Klubnik (Clemson)

Over 260.5

-114

Under 260.5

-114

Clemson Have Won Eight of Their Last Ten Home Games

Clemson have a 8-2 record in their last 10 home games, posting 40.30 points per contest while yielding 22.80.

LSU have five wins and five losses in the last 10 road games, posting 36.30 points per matchup while yielding 31.00.

Last 10 Games		W-L	P	PF	PA	O57.5	U57.5
Clemson Home Stats		8-2	63.10	40.30	22.80	5	5
LSU Away Stats		5-5	67.30	36.30	31.00	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O57.5 = Games Over 57.5 Points
• U57.5 = Games Under 57.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

LSU Tigers Stats

Clemson Tigers Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 53.10 pts in the previous 10 games
• Game Totals on the Road: An average of 67.30 pts in the previous 10 games on the road
• Over 57.5: Covered in 2 of the previous 10 games
• Over 57.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 29.60 pts and allowed 23.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 36.30 pts and allowed 31.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 54.30 pts in the previous 10 games
• Game Totals at Home: An average of 63.10 pts in the previous 10 home games
• Over 57.5: Covered in 5 of the previous 10 games
• Over 57.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 31.80 pts and allowed 22.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 40.30 pts and allowed 22.80 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Duke	1	0	45	17	28	1-0	0-0	1W
NC State	1	0	24	17	7	1-0	0-0	1W
Virginia Tech	0	0	0	0	0	0-0	0-0	-
Virginia	0	0	0	0	0	0-0	0-0	-
Syracuse	0	0	0	0	0	0-0	0-0	-
Stanford	0	1	20	23	-3	0-0	0-1	1L
SMU	0	0	0	0	0	0-0	0-0	-
Pittsburgh	0	0	0	0	0	0-0	0-0	-
Miami	0	0	0	0	0	0-0	0-0	-
North Carolina	0	0	0	0	0	0-0	0-0	-
Louisville	0	0	0	0	0	0-0	0-0	-
Georgia Tech	0	0	0	0	0	0-0	0-0	-
Florida State	0	0	0	0	0	0-0	0-0	-
Clemson	0	0	0	0	0	0-0	0-0	-
California	0	0	0	0	0	0-0	0-0	-
Boston College	0	0	0	0	0	0-0	0-0	-
Wake Forest	0	0	0	0	0	0-0	0-0	-

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Missouri	1	0	61	6	55	1-0	0-0	1W
Alabama	0	0	0	0	0	0-0	0-0	-
Arkansas	0	0	0	0	0	0-0	0-0	-
Auburn	0	0	0	0	0	0-0	0-0	-
Florida	0	0	0	0	0	0-0	0-0	-
Georgia	0	0	0	0	0	0-0	0-0	-
Kentucky	0	0	0	0	0	0-0	0-0	-
LSU	0	0	0	0	0	0-0	0-0	-
Mississippi State	0	0	0	0	0	0-0	0-0	-
Oklahoma	0	0	0	0	0	0-0	0-0	-
Ole Miss	0	0	0	0	0	0-0	0-0	-
South Carolina	0	0	0	0	0	0-0	0-0	-
Tennessee	0	0	0	0	0	0-0	0-0	-
Texas A&M	0	0	0	0	0	0-0	0-0	-
Texas	0	0	0	0	0	0-0	0-0	-
Vanderbilt	0	0	0	0	0	0-0	0-0	-