Northwestern vs Penn State Prediction, Picks & Odds | 11 Oct 2025

College Football Betting Preview: Northwestern vs Penn State

Northwestern square off against Penn State in this NCAAF Week 7 matchup at Beaver Stadium, with kickoff scheduled for 15:30 on Saturday 11 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Penn State Look Set for a Big Win

Let’s go for Penn State at a generous -22.5 on the spread. We really like this pick and are able to get odds of -105 that they beat Northwestern by a big margin.

Taking our side against the spread? Take a moment to read our detailed BetMGM review, then take advantage of the new promo code before you jump in.

41-13 Triumph for Penn State in Last H2H

Northwestern Wildcats have won their previous two games. The latest was a 42-7 home triumph at Northwestern Medicine Field at Martin Stadium against Louisiana-Monroe Warhawks.

Penn State Nittany Lions have suffered defeat in their last two games. Most recently, a 42-37 scoreline occurred on the road at Rose Bowl against UCLA Bruins.

Head-to-Head Statistics

Penn State won the most recent matchup between these teams. A 41-13 victory was registered against Northwestern at Ryan Field.

Quarterbacks

Preston Stone

127.5 Passing Yards

Over -114

Under -114

Drew Allar

222.5 Passing Yards

Over -114

Under -114

Northwestern vs Penn State Prediction & Picks

Head into Northwestern vs Penn State with expert betting insights, including our main match prediction, expected scoreline, key player prop picks and a thoughtfully built bet builder.

Game Prediction

We strongly fancy the chances of Penn State beating the underdogs handsomely in this college football matchup. That is why we’re betting them at -22.5 on the spread at -105.

Knowing which players are injured gives us a valuable edge when making college football predictions. After reviewing the form guide, we turn to the latest stats to shape our picks.

Key Northwestern vs Penn State stats:

• The -22.5 line has been covered by Penn State in 3 of their last 4 games at home this season.
• The -22.5 line has been covered by Penn State in 6 of their last 10 games at home.

Penn State -22.5 Probability

If you go by the top betting apps, there’s a 51.3% chance that our pick is settled as a winner. In the opinion of our cappers, there’s actually a probability of success closer to 60%. It is therefore regarded as a value bet.

If you want bigger odds, then you can move the line by selling points. Choose how many points to sell until you are happy with the juice available.

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Best Bet

Penn State -22.5 @ -105 Bet Now

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Player Prop Picks

Top Pick: Preston Stone Under 127.5 Passing Yards -114

You can place a bet on Preston Stone (Northwestern) at -114 to record fewer than 127.5 passing yards. If you agree with our verdict that the line is too high, this QB Passing Yards wager is worth backing.

Latest Preston Stone Player Prop Odds

Passing Yards

Over 127.5

-114

Under 127.5

-114

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Griffin Wilde Under 40.5 Receiving Yards -114

You can back Griffin Wilde (Northwestern) at -114 to finish with fewer than 40.5 receiving yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the Player Receiving Yards line.

Latest Griffin Wilde Player Prop Odds

Receiving Yards

Over 40.5

-114

Under 40.5

-114

Correct Score Prediction

Northwestern 10 - 41 Penn State

There are lots of different betting angles including the chance to bet on the Lions on the correct score lines. For example, a 41-10 win in their favor is available at huge odds.

Northwestern vs Penn State Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Running Scared of Penn State Win

Penn State are strong -2000 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 95% chance of claiming victory. Northwestern are the underdogs at +1040 and they’re regarded as least likely to win.

22.5 is the spread and 47.5 is the total points line. The Totals offers football bettors an alternative way of getting involved. Those expecting a low total can back Under 47.5 at -104.

You can find a wide range of team props and game lines for every college football matchup, with the best sportsbooks creating lots of different options. Explore the pre-game and in-game selections before placing your wagers.

Moneyline

Northwestern

+1040

Penn State

-2000

Point Spread

Northwestern +22.5

-115

Penn State -22.5

-105

Total Points

Under 47.5

-104

Over 47.5

-118

Player Odds

Receiving Yards

Trebor Pena (Penn State)

Over 43.5

-114

Under 43.5

-114

Griffin Wilde (Northwestern)

Over 40.5

-114

Under 40.5

-114

Kyron Hudson (Penn State)

Over 40.5

-114

Under 40.5

-114

Luke Reynolds (Penn State)

Over 33.5

-114

Under 33.5

-114

Rushing Yards

Kaytron Allen (Penn State)

Over 82.5

-114

Under 82.5

-114

Nicholas Singleton (Penn State)

Over 76.5

-114

Under 76.5

-114

Caleb Komolafe (Northwestern)

Over 45.5

-114

Under 45.5

-114

Passing Yards

Drew Allar (Penn State)

Over 222.5

-114

Under 222.5

-114

Preston Stone (Northwestern)

Over 127.5

-114

Under 127.5

-114

Penn State Have Eight Wins in Their Last Ten Home Games

Penn State have a 8-2 record in their last 10 home games, posting 33.40 points per contest while yielding 10.80.

Northwestern own a 4-6 mark in their past 10 games away from home, averaging 18.30 points scored and 27.50 points allowed.

In their most recent matchup at Beaver Stadium, Penn State got the better of Northwestern 17-7.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Penn State Home Stats		8-2	44.20	33.40	10.80	5	5
Northwestern Away Stats		4-6	45.80	18.30	27.50	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Northwestern Wildcats Stats

Penn State Nittany Lions Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +22.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +22.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -22.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -22.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 46.30 pts in the previous 10 games
• Game Totals on the Road: An average of 45.80 pts in the previous 10 games on the road
• Over 47.5: Covered in 6 of the previous 10 games
• Over 47.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 19.90 pts and allowed 26.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 18.30 pts and allowed 27.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.90 pts in the previous 10 games
• Game Totals at Home: An average of 46.50 pts in the previous 10 home games
• Over 47.5: Covered in 8 of the previous 10 games
• Over 47.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 36.70 pts and allowed 19.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 33.70 pts and allowed 12.80 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Indiana	5	0	239	48	191	4-0	1-0	5W
Oregon	5	0	233	61	172	3-0	2-0	5W
Ohio State	5	0	187	25	162	4-0	1-0	5W
Illinois	5	1	222	144	78	3-0	2-1	2W
Maryland	4	1	150	67	83	3-1	1-0	1L
Michigan	4	1	164	81	83	3-0	1-1	3W
Nebraska	4	1	212	81	131	3-1	1-0	1W
USC	4	1	242	115	127	3-0	1-1	1L
Washington	4	1	197	99	98	2-1	2-0	1W
Penn State	3	2	193	89	104	3-1	0-1	2L
Rutgers	3	2	195	127	68	3-1	0-1	2L
Iowa	3	2	147	78	69	2-1	1-1	1L
Northwestern	3	2	118	85	33	3-1	0-1	2W
Minnesota	3	2	137	107	30	3-0	0-2	1L
Michigan State	3	2	164	153	11	3-0	0-2	2L
Purdue	2	3	139	149	-10	2-2	0-1	3L
Wisconsin	2	3	93	99	-6	2-1	0-2	3L
UCLA	1	4	99	162	-63	1-2	0-2	1W