Northwestern vs USC Prediction, Picks & Odds | 07 Nov 2025
College Football Betting Preview: Northwestern vs USC
Northwestern face USC at LA Memorial Coliseum, with kickoff scheduled for 21:00 on Friday, November 7. Our betting preview features expert NCAAF predictions, picks, the latest betting odds and H2H stats.
There’s everything to like about the -14.5 line that USC have to cover against Northwestern. Take the -105 and feel confident that they get the job done.
Feeling good about our spread pick? Don’t miss the new BetMGM promo code and our expert review as you get ready to make your move.
Northwestern Wildcats were beaten in their previous game and this was on the road at Memorial Stadium. Nebraska Cornhuskers claimed a 28-21 win.
USC Trojans have enjoyed four home wins on the bounce. Their last victory was a 21-17 road success at Memorial Stadium against Nebraska Cornhuskers.
Quarterbacks
Preston Stone
Jayden Maiava
Northwestern vs USC Prediction & Picks
Get the edge with our best Northwestern vs USC tips: a key match prediction, correct score recommendation, top player prop bets and a ready-made bet builder.
Game Prediction
There are odds of -105 that USC will cover the -14.5 line. We think this is a more than generous spread for this college football pick where there is plenty of value available.
The CFB handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.
Key Northwestern vs USC stats:
USC -14.5 Probability
According to the best betting apps, our pick has a 51.3% chance of winning. However, our cappers have this figure closer to 60% based on their in-depth research. The wager can be recommended for this precise reason.
It’s possible to move the line for your selection and this allows bettors to get increasingly bigger odds. If you’re looking for more juice, then this option could tick the boxes.
Before you place your next wager, browse our guide for top betting offers including the latest free bets and welcome bonuses.
Player Prop Picks
Preston Stone (Northwestern) can be backed at -114 to have less than 162.5 passing yards. If you agree with our verdict that the line is too high, this QB Passing Yards wager is worth backing.
The odds for Ja'Kobi Lane (Northwestern) to finish with fewer than 50.5 receiving yards are -114. He could struggle to reach the Player Receiving Yards line, making this prop bet highly appealing.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are USC to cover the -14.5 spread, Over 50.5 on the total and Preston Stone (Northwestern) to have Under 162.5 passing yards.
A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
21
-
38
USC
Correct score betting might be tough to predict but there’s a tasty potential return if you get it right. We’ll try the Trojans to achieve a 38-21 victory at massive odds.
Northwestern vs USC Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The favorites are 88% likely to win according to the sportsbooks’ latest Money Line odds, with USC priced at -714 to triumph in this college game. Northwestern are trading at bigger odds than their opponents and they can be backed at +500.
The spread is calculated to be 13.5, while total points comes in at 52.5. The Totals offers football bettors an alternative way of getting involved. There’s the chance to back Under 52.5 at -115.
The good news is that you can access a huge selection of team props and game lines for most college football matchups. The top sportsbooks have a massive range of pre-game and in-game wagering options.
King Miller is favorite to score a TD at any stage and you can get -345. There is the chance to back the market leader to grab the first touchdown at +260.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Instead of focusing on the overall outcome, some bettors prefer to look at the college football micro betting lines. As the name suggests, it means placing short-term in-game wagers and this might include the Next Play or Next Drive Result.
USC Tough to Crack at Home
USC have strung together four straight victories at LA Memorial Coliseum. They are 8-2 in their last 10 home games, averaging 42.90 points scored and 22.00 points allowed.
Northwestern are 5-5 in their last 10 games on the road, posting 20.30 points per contest while yielding 26.90.
| Last 10 Games | W-L | P | PF | PA | O50.5 | U50.5 | |
|---|---|---|---|---|---|---|---|
 USC Home Stats |
8-2 | 64.90 | 42.90 | 22.00 | 7 | 3 | |
 Northwestern Away Stats |
5-5 | 47.20 | 20.30 | 26.90 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O50.5 = Games Over 50.5 Points
- U50.5 = Games Under 50.5 Points
Latest regular season and playoff games stats.
Northwestern Wildcats Stats
USC Stats
- 5 wins and 5 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- +14.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +14.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road
- -14.5 Betting Line: Have covered the spread in 4 of the last 10 games
- -14.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 43.60 pts in the previous 10 games
- Game Totals on the Road: An average of 47.20 pts in the previous 10 games on the road
- Over 50.5: Covered in 2 of the previous 10 games
- Over 50.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 21.40 pts and allowed 22.20 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 20.30 pts and allowed 26.90 pts in the last 10 games on the road
- Game Totals: An average of 64.70 pts in the previous 10 games
- Game Totals at Home: An average of 66.70 pts in the previous 10 home games
- Over 50.5: Covered in 7 of the previous 10 games
- Over 50.5 at Home: Covered in 8 of the previous 10 home games
- Team Totals: Have scored an average of 38.80 pts and allowed 25.90 pts in the last 10 games
- Team Totals at Home: Have scored an average of 41.60 pts and allowed 25.10 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
13 | 0 | 545 | 141 | 404 | 7-0 | 6-0 | 13W |
Ohio State
|
12 | 1 | 454 | 106 | 348 | 7-1 | 5-0 | 1L |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
|
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
|
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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