Ohio vs Buffalo Prediction, Picks & Odds | 28 Nov 2025
College Football Betting Preview: Ohio vs Buffalo
Ohio square off against Buffalo at University of Buffalo Stadium, with kickoff scheduled for 12:00 on Friday, November 28.
Our betting prediction is for Ohio to cover the appealing -6.5 line in their meeting with Buffalo. They should be able to win by a more comfortable margin and odds of -122 are available on the spread.
Confident in our spread pick? Unlock the current BetMGM promo code and take a moment to read our in-depth site review before you commit to your play.
Ohio Bobcats claimed a victory in their previous game. A 42-14 home win occurred against UMass Minutemen at Peden Stadium.
Buffalo Bulls have lost in back-to-back outings. In a recent home game at University of Buffalo Stadium, they were turned over 37-20 by Miami-Ohio Redhawks.
Head-to-Head Statistics
Ohio triumphed 47-16 when they last played Buffalo. This head-to-head was played at Peden Stadium. Ohio have won four of the past 5 games that these teams have played.
Quarterbacks
Parker Navarro
Ta'Quan Roberson
Ohio vs Buffalo Prediction & Picks
Discover the top Ohio vs Buffalo betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.
Game Prediction
There’s an attractive line of -6.5 when it comes to Ohio for this college football battle. The -122 that the favorites cover the spread has lots of juice and our pick is that they will make it happen.
It’s important to know which players are unavailable for the upcoming action along with the current form of each team. If you're after stats, you're in the right place because they form the foundation of our CFB predictions.
Key Ohio vs Buffalo stats:
Ohio -6.5 Probability
Based on the odds from the top sportsbooks, our pick has a 54.9% chance of winning. After careful examination, our team of cappers calculate this probability to be closer to 60%. This college bet can therefore be backed with confidence.
Looking for more juice from your selection? By moving the betting line, you are able to get a bigger price although you will need to take a riskier wager.
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Player Prop Picks
You can place a bet on Ta'Quan Roberson (Buffalo) at -114 to end with fewer than 196.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.
You can back Sieh Bangura (Ohio) at -114 to have less than 90.5 rushing yards. He could struggle to reach the Player Rushing Yards line, making this prop bet highly appealing.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve got a same game parlay with three options: Ohio -6.5, Over 44.5 points and Ta'Quan Roberson (Buffalo) to have Under 196.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
34
-
20
Buffalo
Should you want a wager that can land a big return, then look no further than the correct score lines. Bet on Ohio to win 34-20 and leverage a massive payout if this happens.
Ohio vs Buffalo Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
With the sportsbooks giving them a 73% probability of winning this college game, Ohio might be a popular parlay pick. That is reflected in their -270 Moneyline betting odds. Buffalo are trading at bigger odds than their opponents and they can be backed at +220.
The current spread is 6.5 and the total points line is 44.5. A wager on the Totals allows football bettors to use the latest data to good effect. Those expecting a low total can back Under 44.5 at -108.
You can find a nice selection of game lines and team props for every college football game, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.
Sieh Bangura is the market leader to score a touchdown at anytime and you can get -161. There is the chance to back the favorite to grab the first TD at odds of +380.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
There are always opportunities to enjoy college football micro betting. It’s generally the case that you will find player and team props in-game and bettors can use their insight to wager on outcomes such as the Next Punt, Turnover or Score Play.
Buffalo Own Five Victories From Previous Ten at Home
Buffalo own a 5-5 mark in their past 10 home games, putting up 31.10 points on average and giving up 25.60.
Ohio have gone 5-5 across their last 10 games away from home, averaging 24.80 points scored and 19.60 points allowed.
Ohio defeated Buffalo 20-10 when the teams last met at University of Buffalo Stadium. The last 3 head-to-heads at University of Buffalo Stadium show Ohio with two wins, while Buffalo have one to their name.
| Last 10 Games | W-L | P | PF | PA | O44.5 | U44.5 | |
|---|---|---|---|---|---|---|---|
 Buffalo Home Stats |
5-5 | 56.70 | 31.10 | 25.60 | 7 | 3 | |
 Ohio Away Stats |
5-5 | 44.40 | 24.80 | 19.60 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O44.5 = Games Over 44.5 Points
- U44.5 = Games Under 44.5 Points
Latest regular season and playoff games stats.
Ohio Bobcats Stats
Buffalo Bulls Stats
- 7 wins and 3 defeats in the last 10 games
- 5 wins and 5 defeats in the last 10 games on the road
- -6.5 Betting Line: Have covered the spread in 6 of the last 10 games
- -6.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road
- +6.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +6.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 49.70 pts in the previous 10 games
- Game Totals on the Road: An average of 44.40 pts in the previous 10 games on the road
- Over 44.5: Covered in 6 of the previous 10 games
- Over 44.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 28.20 pts and allowed 21.50 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 24.80 pts and allowed 19.60 pts in the last 10 games on the road
- Game Totals: An average of 48.00 pts in the previous 10 games
- Game Totals at Home: An average of 56.70 pts in the previous 10 home games
- Over 44.5: Covered in 6 of the previous 10 games
- Over 44.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 25.20 pts and allowed 22.80 pts in the last 10 games
- Team Totals at Home: Have scored an average of 31.10 pts and allowed 25.60 pts in the last 10 home games
| Mid-American | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Western Michigan
|
9 | 4 | 307 | 237 | 70 | 6-1 | 3-3 | 5W |
|
Ohio
|
8 | 4 | 344 | 275 | 69 | 6-0 | 2-4 | 2W |
Toledo
|
8 | 4 | 379 | 146 | 233 | 6-0 | 2-4 | 4W |
Central Michigan
|
7 | 5 | 286 | 272 | 14 | 4-1 | 3-4 | 1L |
Miami (OH)
|
7 | 6 | 326 | 286 | 40 | 4-2 | 3-4 | 1L |
Akron
|
5 | 7 | 267 | 329 | -62 | 3-3 | 2-4 | 1W |
|
Buffalo
|
5 | 7 | 288 | 282 | 6 | 2-5 | 3-2 | 3L |
Kent State
|
5 | 7 | 255 | 403 | -148 | 3-2 | 2-5 | 1W |
Ball State
|
4 | 8 | 190 | 358 | -168 | 4-1 | 0-7 | 3L |
Eastern Michigan
|
4 | 8 | 289 | 357 | -68 | 3-3 | 1-5 | 1L |
Bowling Green
|
4 | 8 | 246 | 291 | -45 | 3-3 | 1-5 | 1W |
Northern Illinois
|
3 | 9 | 205 | 292 | -87 | 2-4 | 1-5 | 2L |
UMass
|
0 | 12 | 133 | 463 | -330 | 0-6 | 0-6 | 12L |
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