Ohio vs Buffalo Prediction, Picks & Odds | 28 Nov 2025

College Football Betting Preview: Ohio vs Buffalo

Ohio square off against Buffalo at University of Buffalo Stadium, with kickoff scheduled for 12:00 on Friday, November 28.

Our betting prediction is for Ohio to cover the appealing -6.5 line in their meeting with Buffalo. They should be able to win by a more comfortable margin and odds of -122 are available on the spread.

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Ohio Bobcats claimed a victory in their previous game. A 42-14 home win occurred against UMass Minutemen at Peden Stadium.

Buffalo Bulls have lost in back-to-back outings. In a recent home game at University of Buffalo Stadium, they were turned over 37-20 by Miami-Ohio Redhawks.

Head-to-Head Statistics

Ohio triumphed 47-16 when they last played Buffalo. This head-to-head was played at Peden Stadium. Ohio have won four of the past 5 games that these teams have played.

Quarterbacks

Parker Navarro

170.5 Passing Yards

Over -114

Under -114

Ta'Quan Roberson

196.5 Passing Yards

Over -114

Under -114

Ohio vs Buffalo Prediction & Picks

Discover the top Ohio vs Buffalo betting angles — from our trusted match prediction and likely score to the best prop plays and a customized bet builder.

Game Prediction

There’s an attractive line of -6.5 when it comes to Ohio for this college football battle. The -122 that the favorites cover the spread has lots of juice and our pick is that they will make it happen.

It’s important to know which players are unavailable for the upcoming action along with the current form of each team. If you're after stats, you're in the right place because they form the foundation of our CFB predictions.

Key Ohio vs Buffalo stats:

• The -6.5 line has been covered by Ohio in 6 of their last 10 games.
• The -6.5 line has been covered by Ohio in 12 of their last 20 games.
• The +6.5 line hasn’t been covered by Buffalo in 3 of their last 5 games.
• The +6.5 line hasn’t been covered by Buffalo in 2 consecutive games.
• The +6.5 line hasn’t been covered by Buffalo in 3 consecutive games against Ohio.

Ohio -6.5 Probability

Based on the odds from the top sportsbooks, our pick has a 54.9% chance of winning. After careful examination, our team of cappers calculate this probability to be closer to 60%. This college bet can therefore be backed with confidence.

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Our Game Prediction

Ohio -6.5 @ -122 Bet Now

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Player Prop Picks

Top Pick: Ta'Quan Roberson Under 196.5 Passing Yards -114

You can place a bet on Ta'Quan Roberson (Buffalo) at -114 to end with fewer than 196.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Ta'Quan Roberson Player Prop Odds

Passing Yards

Over 196.5

-114

Under 196.5

-114

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Sieh Bangura Under 90.5 Rushing Yards -114

You can back Sieh Bangura (Ohio) at -114 to have less than 90.5 rushing yards. He could struggle to reach the Player Rushing Yards line, making this prop bet highly appealing.

Latest Sieh Bangura Player Prop Odds

Rushing Yards

Over 90.5

-114

Under 90.5

-114

Correct Score Prediction

Ohio 34 - 20 Buffalo

Should you want a wager that can land a big return, then look no further than the correct score lines. Bet on Ohio to win 34-20 and leverage a massive payout if this happens.

Ohio vs Buffalo Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

With the sportsbooks giving them a 72% probability of winning this college game, Ohio might be a popular parlay pick. That is reflected in their -256 Moneyline betting odds. Buffalo are trading at bigger odds than their opponents and they can be backed at +210.

The current spread is 6.5 and the total points line is 44.5. A wager on the Totals allows football bettors to use the latest data to good effect. Those expecting a low total can back Under 44.5 at -110.

You can find a nice selection of game lines and team props for every college football game, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Ohio

-256

Buffalo

+210

Point Spread

Ohio -6.5

-122

Buffalo +6.5

-100

Total Points

Under 44.5

-110

Over 44.5

-110

Receiving Yards

Nik McMillan (Buffalo)

Over 103.5

-114

Under 103.5

-114

Chase Hendricks (Ohio)

Over 69.5

-114

Under 69.5

-114

Victor Snow (Buffalo)

Over 62.5

-114

Under 62.5

-114

Rodney Harris II (Ohio)

Over 34.5

-114

Under 34.5

-114

Jasaiah Gathings (Buffalo)

Over 30.5

-114

Under 30.5

-114

Rushing Yards

Sieh Bangura (Ohio)

Over 90.5

-114

Under 90.5

-114

Parker Navarro (Ohio)

Over 67.5

-114

Under 67.5

-114

Passing Yards

Ta'Quan Roberson (Buffalo)

Over 196.5

-114

Under 196.5

-114

Parker Navarro (Ohio)

Over 170.5

-114

Under 170.5

-114

Buffalo Own Five Victories From Previous Ten at Home

Buffalo own a 5-5 mark in their past 10 home games, putting up 31.10 points on average and giving up 25.60.

Ohio have gone 5-5 across their last 10 games away from home, averaging 24.80 points scored and 19.60 points allowed.

Ohio defeated Buffalo 20-10 when the teams last met at University of Buffalo Stadium. The last 3 head-to-heads at University of Buffalo Stadium show Ohio with two wins, while Buffalo have one to their name.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Buffalo Home Stats		5-5	56.70	31.10	25.60	7	3
Ohio Away Stats		5-5	44.40	24.80	19.60	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

Ohio Bobcats Stats

Buffalo Bulls Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -6.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -6.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +6.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +6.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 49.70 pts in the previous 10 games
• Game Totals on the Road: An average of 44.40 pts in the previous 10 games on the road
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 28.20 pts and allowed 21.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.80 pts and allowed 19.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 48.00 pts in the previous 10 games
• Game Totals at Home: An average of 56.70 pts in the previous 10 home games
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 25.20 pts and allowed 22.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.10 pts and allowed 25.60 pts in the last 10 home games

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