Old Dominion vs South Florida Prediction, Picks & Odds | 17 Dec 2025

College Football Betting Preview: Old Dominion vs South Florida

Old Dominion square off against South Florida at Camping World Stadium, with kickoff scheduled for 17:00 on Wednesday, December 17.

The total line of 53.5 points looks pretty low and we can take advantage by backing the Overs at -110. We can see South Florida and Old Dominion combining to go bigger.

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Old Dominion Monarchs made it five consecutive wins after a 27-10 home success over Georgia State Panthers at S.B. Ballard Stadium.

South Florida last game was a 52-3 victory over Rice Owls at Raymond James Stadium. That means it’s now been six home wins on the spin.

Old Dominion vs South Florida Prediction & Picks

Discover our expert Old Dominion vs South Florida betting tips, featuring a match prediction, correct score suggestion and bet builder advice. Scroll down for full analysis.

Game Prediction

We’ll take a chance on a total bet after finding that the line is set at a generous 53.5 points. Expect this number to be surpassed at -110 for this college football matchup.

We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key Old Dominion vs South Florida stats:

• The 53.5 line has been covered in 4 of the last 5 Old Dominion games on the road.
• The 53.5 line has been covered in 4 of the last 6 Old Dominion games on the road this season.
• The 53.5 line has been covered in the last 10 South Florida games.
• The 53.5 line has been covered in 16 of the last 20 South Florida games.

Over 53.5 Probability

Based on the odds from the top sportsbooks, our pick has a 52.4% chance of winning. Based on our analysts in-depth research, we calculate the actual probability to be closer to 60%. The bet can be recommended for this precise reason.

Secure more attractive betting odds by moving the line when you place an Over wager. You can choose from a range of options on the Totals until you’re happy with your bet.

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Our Game Prediction

Over 53.5 Points @ -110 Bet Now

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Correct Score Prediction

Old Dominion 27 - 31 South Florida

Don’t pass up the opportunity to have a speculative bet on the Bulls to land a 31-27 win. We don’t think that there will be too much between the teams.

Old Dominion vs South Florida Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The sportsbooks’ betting odds have South Florida as -152 favorites for this college game, implying that they are 60% likely to win. For those wanting to oppose the market leader, you can get +128 about Old Dominion.

The spread is calculated to be 2.5, while total points comes in at 53.5. There are many ways to wager on football including the Totals. If you want to back Over 53.5, it’s -110.

You can find a nice selection of game lines and team props for every college football game, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Old Dominion

+128

USF

-152

Point Spread

Old Dominion +2.5

-100

USF -2.5

-122

Total Points

Under 53.5

-110

Over 53.5

-110

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Latest regular season and playoff games stats.

Old Dominion Monarchs Stats

South Florida Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 52.20 pts in the previous 10 games
• Game Totals on the Road: An average of 60.30 pts in the previous 10 games on the road
• Over 53.5: Covered in 5 of the previous 10 games
• Over 53.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 32.40 pts and allowed 19.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 30.40 pts and allowed 29.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 72.10 pts in the previous 10 games
• Game Totals at Home: An average of 60.40 pts in the previous 10 home games
• Over 53.5: Covered in the previous 10 games
• Over 53.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 46.40 pts and allowed 25.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 41.40 pts and allowed 19.00 pts in the last 10 home games

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