Ole Miss vs Oklahoma Prediction, Picks & Odds | 25 Oct 2025
College Football Betting Preview: Ole Miss vs Oklahoma
Ole Miss battle Oklahoma in this NCAAF Week 9 matchup at Gaylord Family Memorial Stadium, with kickoff scheduled for 12:00 on Saturday, October 25. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Bet on Oklahoma against the spread, with an attractive line of -5.5 that they have the upper hand against Ole Miss. There are odds of -110 that are currently on offer for this selection.
Following our advice? Secure the latest BetMGM promo code and read our expert review of the sportsbook before deciding where to put your money.
Ole Miss suffered a defeat in their previous game. A 43-35 scoreline occurred on the road at Solider Field against Georgia Bulldogs.
Oklahoma Sooners have now achieved four straight home wins. In their last game, they won on the road at Williams-Brice Stadium when beating South Carolina Gamecocks 26-7.
Head-to-Head Statistics
Ole Miss beat Oklahoma in their last head-to-head matchup. It was a 26-14 scoreline at Vaught-Hemingway Stadium.
Quarterbacks
Trinidad Chambliss
John Mateer
Ole Miss vs Oklahoma Prediction & Picks
We bring you the complete Ole Miss vs Oklahoma betting insight, including our top match prediction, correct score forecast, player prop advice and a ready-made bet builder.
Game Prediction
We expect Oklahoma to cover the -5.5 line on the spread. This is a good number and that’s why we’re playing the favorites at -110 for this college football matchup.
The college football picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every pick.
Key Ole Miss vs Oklahoma stats:
Oklahoma -5.5 Probability
According to the best betting apps, there’s a 52.4% chance that our pick is settled as a winner. However, our cappers research has found that the actual probability is between 55-60%. This is why we can recommend this college wager.
If you want to land a big potential return from a small stake, then a Bet Builder could be a good way to go. Back Oklahoma against the spread in a combination with other picks.
Don’t place your bets without seeing the latest offers. Our in-depth guide helps you find the best welcome bonuses available today.
Player Prop Picks
You can back John Mateer (Oklahoma) at -114 to rack up over 245.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.
You can place a bet on Isaiah Sategna III (Oklahoma) at -114 to go over 70.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve loaded up a same game parlay with the combined picks of Oklahoma -5.5, Under 53.5 and John Mateer (Oklahoma) to have Over 245.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
21
-
28
Oklahoma
You don’t need a big stake to enjoy a massive return by getting this correct score right. We’re going for Oklahoma to achieve a 28-21 win and hopefully this goes close.
Ole Miss vs Oklahoma Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
With a 65% chance of securing victory, Oklahoma are favorites for this college game and the sportsbooks have them at betting odds of -189. Ole Miss are trading at bigger odds than their opponents and they can be backed at +158.
The spread is currently 5.5, with the total points line at 52.5. A Total wager is always available and can often provide value selections. Those who wager Under 52.5 can get -115.
The good news is that you can access a wide range of team props and game lines for most college football clashes. The top betting sites offer a great selection of pre-game and in-game wagering options.
Kewan Lacy is available at -164 when it comes to Anytime Touchdown Scorer. The favorite is now priced at odds of +480 to score the first TD.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.
Will Oklahoma Extend Their Home Winning Streak?
Oklahoma have posted six consecutive wins at Gaylord Family Memorial Stadium. They have seven wins and three losses in the last 10 home games, averaging 27.10 points on offense and surrendering 16.30 on defense.
Ole Miss own a 6-4 mark in their past 10 games away from home, scoring 31.00 points per contest and conceding 24.30.
| Last 10 Games | W-L | P | PF | PA | O53.5 | U53.5 | |
|---|---|---|---|---|---|---|---|
 Oklahoma Home Stats |
7-3 | 43.40 | 27.10 | 16.30 | 1 | 9 | |
 Ole Miss Away Stats |
6-4 | 55.30 | 31.00 | 24.30 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O53.5 = Games Over 53.5 Points
- U53.5 = Games Under 53.5 Points
Latest regular season and playoff games stats.
Ole Miss Stats
Oklahoma Sooners Stats
- 8 wins and 2 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +5.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -5.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -5.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 57.30 pts in the previous 10 games
- Game Totals on the Road: An average of 55.30 pts in the previous 10 games on the road
- Over 53.5: Covered in 5 of the previous 10 games
- Over 53.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 35.70 pts and allowed 21.60 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 31.00 pts and allowed 24.30 pts in the last 10 games on the road
- Game Totals: An average of 38.90 pts in the previous 10 games
- Game Totals at Home: An average of 43.40 pts in the previous 10 home games
- Over 53.5: Covered in 1 of the previous 10 games
- Over 53.5 at Home: Covered in 1 of the previous 10 home games
- Team Totals: Have scored an average of 26.20 pts and allowed 12.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 27.10 pts and allowed 16.30 pts in the last 10 home games
| Southeastern | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Georgia
|
12 | 1 | 415 | 207 | 208 | 6-1 | 6-0 | 9W |
|
Ole Miss
|
11 | 1 | 447 | 241 | 206 | 8-0 | 3-1 | 5W |
Texas A&M
|
11 | 1 | 436 | 263 | 173 | 7-0 | 4-1 | 1L |
|
Oklahoma
|
10 | 2 | 317 | 167 | 150 | 6-1 | 4-1 | 4W |
Vanderbilt
|
10 | 2 | 473 | 263 | 210 | 7-0 | 3-2 | 3W |
Alabama
|
10 | 3 | 406 | 226 | 180 | 6-2 | 4-1 | 1L |
Texas
|
9 | 3 | 355 | 237 | 118 | 7-0 | 2-3 | 2W |
Missouri
|
8 | 4 | 386 | 233 | 153 | 6-2 | 2-2 | 1W |
Tennessee
|
8 | 4 | 489 | 345 | 144 | 5-3 | 3-1 | 1L |
LSU
|
7 | 5 | 262 | 220 | 42 | 6-1 | 1-4 | 1L |
Kentucky
|
5 | 7 | 276 | 317 | -41 | 4-3 | 1-4 | 2L |
Auburn
|
5 | 7 | 321 | 248 | 73 | 3-4 | 2-3 | 1L |
Mississippi State
|
5 | 7 | 366 | 350 | 16 | 3-4 | 2-3 | 3L |
Florida
|
4 | 8 | 259 | 288 | -29 | 4-3 | 0-5 | 1W |
South Carolina
|
4 | 8 | 272 | 265 | 7 | 4-4 | 0-4 | 1L |
Arkansas
|
2 | 10 | 395 | 406 | -11 | 2-5 | 0-5 | 10L |
Metaloglobus
Csikszereda
Predictions
11:00 - Wed 04 Feb
SuperLiga
UTA Arad
CFR Cluj
Predictions
11:30 - Wed 04 Feb
Super League Greece
Asteras Tripolis
Olympiacos
Predictions
12:00 - Wed 04 Feb
EuroCup
Besiktas
Turk Telekom
Predictions
12:00 - Wed 04 Feb
EuroCup
Lietkabelis
Panionios
Predictions
13:00 - Wed 04 Feb
EuroCup
Hapoel Jerusalem
Cluj-Napoca
Predictions