Ole Miss vs Oklahoma Prediction, Picks & Odds | 25 Oct 2025

College Football Betting Preview: Ole Miss vs Oklahoma

Ole Miss battle Oklahoma in this NCAAF Week 9 matchup at Gaylord Family Memorial Stadium, with kickoff scheduled for 12:00 on Saturday 25 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We’re Expecting Oklahoma to Cover the Line

Bet on Oklahoma against the spread, with an attractive line of -5.5 that they have the upper hand against Ole Miss. There are odds of -110 that are currently on offer for this selection.

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Teams’ Last Clash Saw 26-14 Ole Miss Win

Ole Miss suffered a defeat in their previous game. A 43-35 scoreline occurred on the road at Solider Field against Georgia Bulldogs.

Oklahoma Sooners have now achieved four straight home wins. In their last game, they won on the road at Williams-Brice Stadium when beating South Carolina Gamecocks 26-7.

Head-to-Head Statistics

Ole Miss beat Oklahoma in their last head-to-head matchup. It was a 26-14 scoreline at Vaught-Hemingway Stadium.

Quarterbacks

Trinidad Chambliss

248.5 Passing Yards

Over -114

Under -114

John Mateer

235.5 Passing Yards

Over -114

Under -114

Ole Miss vs Oklahoma Prediction & Picks

We bring you the complete Ole Miss vs Oklahoma betting insight, including our top match prediction, correct score forecast, player prop advice and a ready-made bet builder.

Game Prediction

We expect Oklahoma to cover the -5.5 line on the spread. This is a good number and that’s why we’re playing the favorites at -110 for this college football matchup.

The college football picks at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every pick.

Key Ole Miss vs Oklahoma stats:

• The -5.5 line has been covered by Oklahoma in 6 consecutive games at home.
• The -5.5 line has been covered by Oklahoma in 7 of their last 10 games.
• The -5.5 line has been covered by Oklahoma in 14 of their last 20 games at home.

Oklahoma -5.5 Probability

According to the best betting apps, there’s a 52.4% chance that our pick is settled as a winner. However, our cappers research has found that the actual probability is between 55-60%. This is why we can recommend this college wager.

If you want to land a big potential return from a small stake, then a Bet Builder could be a good way to go. Back Oklahoma against the spread in a combination with other picks.

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Best Bet

Oklahoma -5.5 @ -110 Bet Now

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Player Prop Picks

Top Pick: John Mateer Over 245.5 Passing Yards -114

You can back John Mateer (Oklahoma) at -114 to rack up over 245.5 passing yards. The line for him on the Overs is highly appealing, with QB Passing Yards bettors able to get plenty of juice.

Latest John Mateer Player Prop Odds

Passing Yards

Over 235.5

-114

Under 235.5

-114

Rushing Yards

Over 39.5

-114

Under 39.5

-114

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Isaiah Sategna III Over 70.5 Receiving Yards -114

You can place a bet on Isaiah Sategna III (Oklahoma) at -114 to go over 70.5 receiving yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this Player Receiving Yards pick.

Latest Isaiah Sategna III Player Prop Odds

Receiving Yards

Over 70.5

-114

Under 70.5

-114

Correct Score Prediction

Ole Miss 21 - 28 Oklahoma

You don’t need a big stake to enjoy a massive return by getting this correct score right. We’re going for Oklahoma to achieve a 28-21 win and hopefully this goes close.

Ole Miss vs Oklahoma Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Oklahoma Trading at Shorter Odds Than Ole Miss

With a 67% chance of securing victory, Oklahoma are favorites for this college game and the sportsbooks have them at betting odds of -200. Ole Miss are trading at bigger odds than their opponents and they can be backed at +168.

The spread is currently 5.5, with the total points line at 52.5. A Total wager is always available and can often provide value selections. Those who wager Under 52.5 can get -110.

The good news is that you can access a wide range of team props and game lines for most college football clashes. The top betting sites offer a great selection of pre-game and in-game wagering options.

Moneyline

Ole Miss

+168

Oklahoma

-200

Point Spread

Ole Miss +5.5

-112

Oklahoma -5.5

-108

Total Points

Under 52.5

-110

Over 52.5

-110

Player Odds

Receiving Yards

Isaiah Sategna III (Oklahoma)

Over 70.5

-114

Under 70.5

-114

Deion Burks (Oklahoma)

Over 48.5

-114

Under 48.5

-114

Dae'Quan Wright (Ole Miss)

Over 43.5

-114

Under 43.5

-114

Deuce Alexander (Ole Miss)

Over 42.5

-114

Under 42.5

-114

De'Zhaun Stribling (Ole Miss)

Over 39.5

-114

Under 39.5

-114

Jaren Kanak (Oklahoma)

Over 38.5

-114

Under 38.5

-114

Cayden Lee (Ole Miss)

Over 35.5

-114

Under 35.5

-114

Harrison Wallace III (Ole Miss)

Over 34.5

-114

Under 34.5

-114

Keontez Lewis (Oklahoma)

Over 34.5

-114

Under 34.5

-114

Rushing Yards

Kewan Lacy (Ole Miss)

Over 65.5

-114

Under 65.5

-114

Tory Blaylock (Oklahoma)

Over 55.5

-114

Under 55.5

-114

John Mateer (Oklahoma)

Over 39.5

-114

Under 39.5

-114

Trinidad Chambliss (Ole Miss)

Over 30.5

-114

Under 30.5

-114

Passing Yards

Trinidad Chambliss (Ole Miss)

Over 248.5

-114

Under 248.5

-114

John Mateer (Oklahoma)

Over 235.5

-114

Under 235.5

-114

Will Oklahoma Extend Their Home Winning Streak?

Oklahoma have posted six consecutive wins at Gaylord Family Memorial Stadium. They have seven wins and three losses in the last 10 home games, averaging 27.10 points on offense and surrendering 16.30 on defense.

Ole Miss own a 6-4 mark in their past 10 games away from home, scoring 31.00 points per contest and conceding 24.30.

Last 10 Games		W-L	P	PF	PA	O53.5	U53.5
Oklahoma Home Stats		7-3	43.40	27.10	16.30	1	9
Ole Miss Away Stats		6-4	55.30	31.00	24.30	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O53.5 = Games Over 53.5 Points
• U53.5 = Games Under 53.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Ole Miss Stats

Oklahoma Sooners Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 57.30 pts in the previous 10 games
• Game Totals on the Road: An average of 55.30 pts in the previous 10 games on the road
• Over 53.5: Covered in 5 of the previous 10 games
• Over 53.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 35.70 pts and allowed 21.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 31.00 pts and allowed 24.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 38.90 pts in the previous 10 games
• Game Totals at Home: An average of 43.40 pts in the previous 10 home games
• Over 53.5: Covered in 1 of the previous 10 games
• Over 53.5 at Home: Covered in 1 of the previous 10 home games
• Team Totals: Have scored an average of 26.20 pts and allowed 12.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 27.10 pts and allowed 16.30 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Texas A&M	7	0	253	164	89	5-0	2-0	7W
Alabama	6	1	246	124	122	4-0	2-1	6W
Georgia	6	1	236	137	99	4-1	2-0	3W
Missouri	6	1	273	117	156	5-1	1-0	1W
Oklahoma	6	1	201	66	135	4-0	2-1	1W
Ole Miss	6	1	262	158	104	5-0	1-1	1L
Vanderbilt	6	1	290	140	150	4-0	2-1	1W
LSU	5	2	179	102	77	4-0	1-2	1L
Tennessee	5	2	309	213	96	4-1	1-1	1L
Texas	5	2	187	79	108	4-0	1-2	2W
Mississippi State	4	3	223	142	81	3-1	1-2	3L
Auburn	3	4	165	125	40	2-2	1-2	4L
Florida	3	4	157	140	17	3-1	0-3	1W
South Carolina	3	4	141	140	1	3-2	0-2	2L
Kentucky	2	4	135	155	-20	2-2	0-2	3L
Arkansas	2	5	260	229	31	2-2	0-3	5L