Penn State vs Clemson Prediction, Picks & Odds | 27 Dec 2025

College Football Betting Preview: Penn State vs Clemson

Penn State battle Clemson at Yankee Stadium, with kickoff scheduled for 12:00 on Saturday, December 27.

Clemson can cover the -3.5 line on the spread. This is a good number and that’s why we’re playing them at -100 to get the better of Penn State.

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Penn State Nittany Lions have triumphed in their previous three games. The latest was on the road where Rutgers Scarlet Knights were beaten 40-36 at SHI Stadium.

Clemson Tigers won last time out by a 28-14 scoreline. On the road against South Carolina Gamecocks at Williams-Brice Stadium, they made it four wins on the spin.

Penn State vs Clemson Prediction & Picks

The Penn State vs Clemson betting tips feature sharp analysis across major markets, including a key match prediction, correct score guidance and a ready-made bet builder.

Game Prediction

There’s a strong case for backing Clemson on the spread in this college football matchup. The line looks really appealing considering you can get -100 when it comes to the favorites at -3.5.

The CFB handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.

Key Penn State vs Clemson stats:

• The -3.5 line has been covered by Clemson in 3 of their last 5 games.
• The -3.5 line has been covered by Clemson in 2 consecutive games.

Clemson -3.5 Probability

The best sportsbooks make it a 50% chance that our pick is settled as a winner. However, our analysts think that the probability sits between 55-60% taking all factors into consideration. It's why we think it’s worth placing this college wager.

If you want to secure a bigger possible payout on your bet, there’s the option to move the line. Take a look at the various prices and see which line you think will be covered.

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Our Game Prediction

Clemson -3.5 @ -100 Bet Now

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Correct Score Prediction

Penn State 24 - 34 Clemson

There’s the chance to back Clemson in lots of different ways and this includes predicting the correct winning score. We’ll go for a 34-24 triumph in their favor.

Penn State vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

The Clemson odds have been priced up by the sportsbooks and they are -154 betting favorites to land victory in this college game which means a 61% chance of winning. The market suggests that Penn State are least likely to win at +130.

The current spread is 3.5 and total points is 48.5. Football fans love the chance to get an alternative angle by going for a Total wager. Those that want to back Under 48.5 can find odds of -110 available.

If you're wagering on college football, it's a good idea to visit the top betting apps and browse the extensive selection of team props and game lines. You'll find great opportunities to place bets both pre-game and in-game.

Moneyline

Penn State

+130

Clemson

-154

Point Spread

Penn State +3.5

-122

Clemson -3.5

-100

Total Points

Under 48.5

-110

Over 48.5

-110

If you have a view on Player Interceptions, Passing Attempts or Longest Pass Completion, then the player prop betting could be up your street. It’s a great way of wagering on a player or quarterback to perform well.

There are always opportunities to enjoy college football micro betting. It’s generally the case that you will find player and team props in-game and bettors can use their insight to wager on outcomes such as the Next Punt, Turnover or Score Play.

Latest regular season and playoff games stats.

Penn State Nittany Lions Stats

Clemson Tigers Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -3.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -3.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 54.70 pts in the previous 10 games
• Game Totals on the Road: An average of 57.20 pts in the previous 10 games on the road
• Over 48.5: Covered in 7 of the previous 10 games
• Over 48.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.10 pts and allowed 24.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 31.40 pts and allowed 25.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 51.90 pts in the previous 10 games
• Game Totals at Home: An average of 51.40 pts in the previous 10 home games
• Over 48.5: Covered in 5 of the previous 10 games
• Over 48.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 30.70 pts and allowed 21.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.20 pts and allowed 23.20 pts in the last 10 home games

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