Pittsburgh vs Syracuse Prediction, Picks & Odds | 18 Oct 2025
College Football Betting Preview: Pitt vs Syracuse
Pitt go up against Syracuse in this NCAAF Week 8 clash at JMA Wireless Dome, with kickoff scheduled for 19:30 on Saturday, October 18. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
The best betting angle could be wagering on the totals when Syracuse clash with Pitt. Our prediction is for Over 54.5 points to be scored at odds of -115.
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Pittsburgh Panthers have won back-to-back games. A 34-31 triumph recently occurred on the road at Doak Campbell Stadium when playing Florida State Seminoles.
Syracuse Orange have been defeated in back-to-back games. On the road, they recently suffered a 31-18 loss against SMU Mustangs at Gerald J. Ford Stadium.
Head-to-Head Statistics
It was Pitt who came out on top when they last played Syracuse. At Acrisure Stadium, a 41-13 win was recorded. The previous 6 games featuring these teams have resulted in five Pitt victories.
Quarterbacks
Mason Heintschel
Rickie Collins
Pittsburgh vs Syracuse Prediction & Picks
Dive into our full Pittsburgh vs Syracuse betting preview, featuring an expert match prediction, a projected scoreline, top player prop bets and a bet builder designed for value.
Game Prediction
We’re forecasting that the two teams will produce a significant combined points total in this college football showdown. Therefore, our pick is to take the -115 that there are Over 54.5 points.
It’s important to know which players are unavailable for the upcoming action along with the current form of each team. If you're after stats, you're in the right place because they form the foundation of our CFB predictions.
Key Pittsburgh vs Syracuse stats:
Over 54.5 Probability
Based on the odds from the top sportsbooks, our pick has a 53.5% chance of winning. After careful examination, our analysts calculate this probability to be closer to 60%. This college wager can therefore be backed with confidence.
Want more juice from your Over wager on the Totals? Bigger odds can be found if you move the line and go for a riskier bet. You can choose from a range of options.
Before you bet, take a look at our complete guide to the best free bets and new customer bonuses on offer now.
Player Prop Picks
You can back Mason Heintschel (Pitt) at -114 to accumulate over 274.5 passing yards. With confidence, we can back him to cover the generous QB Passing Yards line, as all the signs point to him reaching the expected total.
Kenny Johnson (Syracuse) is available at -114 to go over 61.5 receiving yards. There’s an opportunity to place a Player Receiving Yards bet, with him capable of covering an appealing line.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Over 54.5, along with Syracuse +10.5 on the spread and Mason Heintschel (Pitt) to go Over 274.5 passing yards.
There are many options when you place a same game parlay. You can go through the football lines and identify your favorite outcomes before combining the odds on the bet slip. Personalised betting doesn’t come any better.
Correct Score Prediction
30
-
27
Syracuse
There’s every chance that this is going to be a close matchup and we’ll have a play on Pittsburgh achieving a 30-27 winning scoreline. Hopefully this can go close.
Pittsburgh vs Syracuse Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Pittsburgh are regarded as having a 76% chance of winning this college game according to the latest betting odds. The sportsbooks have priced them up at -323. Syracuse are regarded as a long shot to win and you can currently back them at +260.
The current spread is 9.5 and total points is 54.5. There are many ways to wager on football including the Totals. If you want to wager Over 54.5, there are odds of -115.
If you’re betting on college football, we recommend heading to the top betting apps and scanning through the many team props and game lines. There’s a chance to wager pre-game and in-game.
There is -238 available that Desmond Reid scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure +380.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
Among the various options for wagering on college football, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as whether a touchdown will be scored within the next few minutes.
Syracuse Have Collected Eight Wins in Past Ten Home Games
Syracuse have gone 8-2 across their last 10 home games, averaging 34.20 points scored and 26.50 points allowed.
Pitt have three wins and seven losses in the last 10 games away from home, putting up 25.50 points on average and giving up 33.80.
Syracuse defeated Pitt 28-13 the last time they played at JMA Wireless Dome. Across the past 3 head-to-head meetings at JMA Wireless Dome, Pitt have recorded two wins, with Syracuse winning once.
| Last 10 Games | W-L | P | PF | PA | O54.5 | U54.5 | |
|---|---|---|---|---|---|---|---|
 Syracuse Home Stats |
8-2 | 60.70 | 34.20 | 26.50 | 7 | 3 | |
 Pittsburgh Away Stats |
3-7 | 59.30 | 25.50 | 33.80 | 7 | 3 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O54.5 = Games Over 54.5 Points
- U54.5 = Games Under 54.5 Points
Latest regular season and playoff games stats.
Pittsburgh Stats
Syracuse Orange Stats
- 4 wins and 6 defeats in the last 10 games
- 3 wins and 7 defeats in the last 10 games on the road
- -10.5 Betting Line: Have covered the spread in 3 of the last 10 games
- -10.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road
- +10.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +10.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 60.90 pts in the previous 10 games
- Game Totals on the Road: An average of 59.30 pts in the previous 10 games on the road
- Over 54.5: Covered in 8 of the previous 10 games
- Over 54.5 on the Road: Covered in 7 of the previous 10 games on the road
- Team Totals: Have scored an average of 33.70 pts and allowed 27.20 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 25.50 pts and allowed 33.80 pts in the last 10 games on the road
- Game Totals: An average of 63.30 pts in the previous 10 games
- Game Totals at Home: An average of 60.70 pts in the previous 10 home games
- Over 54.5: Covered in 7 of the previous 10 games
- Over 54.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 33.20 pts and allowed 30.10 pts in the last 10 games
- Team Totals at Home: Have scored an average of 34.20 pts and allowed 26.50 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
|
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
|
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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