Purdue vs Notre Dame Prediction, Picks & Odds | 20 Sep 2025
College Football Betting Preview: Purdue vs Notre Dame
Purdue clash with Notre Dame in this NCAAF Week 4 matchup at Notre Dame Stadium, with kickoff scheduled for 15:30 on Saturday, September 20. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
We’re forecasting that Notre Dame and Purdue will produce a significant combined points total. Therefore, our prediction is to take the -114 that there are Over 51.5 points.
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Purdue Boilermakers lost when they last took to the field. At Ross-Ade Stadium, they were turned over 33-17 at home to USC Trojans.
Notre Dame Fighting Irish were beaten 41-40 at Notre Dame Stadium in their last game. This loss at home to Texas A&M Aggies was their second straight defeat.
Head-to-Head Statistics
Notre Dame beat Purdue in their last head-to-head matchup. It was a 66-7 scoreline at Ross-Ade Stadium.
Quarterbacks
Ryan Browne
CJ Carr
Purdue vs Notre Dame Prediction & Picks
Our Purdue vs Notre Dame tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.
Game Prediction
Over 51.5 points seems like a realistic outcome for this college football showdown. We’re taking odds of -114 on the basis that the total line is too low.
The CFB handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.
Key Purdue vs Notre Dame stats:
Over 51.5 Probability
If you go by the best sportsbooks, our pick has a 53.2% prospect of winning. However, our analysts have this number closer to 60% based on their in-depth research. It is the reason why we are recommending this college wager.
The sportsbooks allow you to shoot for bigger odds by moving the line on the Totals. Choose a number where you’re happy and get more juice.
Thinking about placing a wager? Explore our updated guide filled with top betting offers, free bets, and promotions.
Player Prop Picks
You can place a bet on Ryan Browne (Purdue) at -114 to reach over 172.5 passing yards. He looks capable of covering the line and that leads us to taking this QB Passing Yards bet.
The odds for Jeremiyah Love (Purdue) to go beyond 101.5 rushing yards stand at -114. We're confident in him covering the Player Rushing Yards line and hitting our Over bet.
Same Game Parlay Picks
Get in the game with a same game parlay. Our picks are Over 51.5 on the total, Notre Dame to cover the -25.5 spread and Ryan Browne (Purdue) to go Over 172.5 passing yards.
Should you want to back different outcomes for the same game, then a football same game parlay will suit your needs. The betting sites create this personalised wagering tool where you can make different picks and combine the odds together.
Correct Score Prediction
13
-
45
Notre Dame
Correct score betting might be tough to predict but there’s a tasty potential return if you get it right. We’ll try the Irish to achieve a 45-13 victory at massive odds.
Purdue vs Notre Dame Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
The latest Moneyline betting odds give Notre Dame a 97% chance of winning this college game which means they’re overwhelming -3333 favorites with the sportsbooks. For those wanting to back Purdue, you will find +1280 about the underdogs.
There is a spread of 24.5 and total points has a line of 50.5. The beauty of the Totals is that you only have to choose from one of two options. If you're keen on Over 50.5, this selection is available at -110.
If you’re getting ready to place a college football bet, head over to one of the top betting apps and explore the wide variety of game lines and team props. Take your time to spot the most appealing opportunities.
Jeremiyah Love can be backed to score a touchdown at anytime at -385. He is the favorite to score the first TD at odds of +230.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
For those looking to enjoy a thrilling in-game wager, then college football micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.
Notre Dame Have Eight Wins From Last Ten Home Games
Notre Dame own a 8-2 mark in their past 10 home games, averaging 36.50 points scored and 14.70 points allowed.
Purdue have dropped ten consecutive away games. They have zero win and ten losses in the last 10 road games, scoring 14.90 points per matchup and conceding 39.00.
In their last matchup at Notre Dame Stadium, Notre Dame came out on top 27-13 against Purdue.
| Last 10 Games | W-L | P | PF | PA | O51.5 | U51.5 | |
|---|---|---|---|---|---|---|---|
 Notre Dame Home Stats |
8-2 | 51.20 | 36.50 | 14.70 | 5 | 5 | |
 Purdue Away Stats |
0-10 | 53.90 | 14.90 | 39.00 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O51.5 = Games Over 51.5 Points
- U51.5 = Games Under 51.5 Points
Latest regular season and playoff games stats.
Purdue Boilermakers Stats
Notre Dame Fighting Irish Stats
- 2 wins and 8 defeats in the last 10 games
- 0 wins and 10 defeats in the last 10 games on the road
- +25.5 Betting Line: Have covered the spread in 6 of the last 10 games
- +25.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road
- -25.5 Betting Line: Have covered the spread in 2 of the last 10 games
- -25.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games
- Game Totals: An average of 52.30 pts in the previous 10 games
- Game Totals on the Road: An average of 53.90 pts in the previous 10 games on the road
- Over 51.5: Covered in 3 of the previous 10 games
- Over 51.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 17.80 pts and allowed 34.50 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 14.90 pts and allowed 39.00 pts in the last 10 games on the road
- Game Totals: An average of 56.80 pts in the previous 10 games
- Game Totals at Home: An average of 52.10 pts in the previous 10 home games
- Over 51.5: Covered in 5 of the previous 10 games
- Over 51.5 at Home: Covered in 6 of the previous 10 home games
- Team Totals: Have scored an average of 34.90 pts and allowed 21.90 pts in the last 10 games
- Team Totals at Home: Have scored an average of 34.80 pts and allowed 17.30 pts in the last 10 home games
| Independents I-A | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Notre Dame
|
10 | 2 | 504 | 211 | 293 | 6-1 | 4-1 | 10W |
UConn
|
9 | 3 | 443 | 310 | 133 | 6-0 | 3-3 | 4W |
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
12 | 0 | 532 | 131 | 401 | 7-0 | 5-0 | 12W |
Ohio State
|
12 | 0 | 444 | 93 | 351 | 7-0 | 5-0 | 12W |
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
|
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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