South Florida vs UAB Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: South Florida vs UAB

South Florida go up against UAB at Protective Stadium, with kickoff scheduled for 15:00 on Saturday, November 22.

There’s a strong case for taking the -108 that South Florida can overcome the -21.5 when they go up against UAB. The favorites should be capable of a big victory and that means we’re backing them against the spread.

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South Florida have now lost back-to-back road games. In their previous game, Navy Midshipmen won 41-38 at Navy Marine Corps Memorial Stadium.

UAB Blazers were beaten 53-24 at Protective Stadium in their last game. This loss at home to North Texas Mean Green was their third straight defeat.

Head-to-Head Statistics

USF beat UAB in their last head-to-head matchup. It was a 35-25 scoreline at Raymond James Stadium.

South Florida vs UAB Prediction & Picks

Our South Florida vs UAB betting guide delivers expert insight, including a main match pick, our correct score angle and bet builder recommendations. Dive into each section below for more.

Game Prediction

There are odds of -108 that South Florida will cover the -21.5 spread in this college football matchup. We're confident this is a good betting line for a pick where there should be lots of value available.

Recent form is always part of the equation and we combine it with team news as soon as it’s available. To deliver expert predictions, our college football handicappers also analyze the latest stats to ensure we’re working with the best information possible.

Key South Florida vs UAB stats:

• The -21.5 line has been covered by South Florida in 6 of their last 10 games.
• The -21.5 line has been covered by South Florida in 3 of their last 5 games.

USF -21.5 Probability

When you look at the latest odds, our pick has a 51.8% chance of delivering a return. After careful examination, our analysts have this probability somewhere between 55-60%. This college wager can therefore be backed with confidence.

There are options to buy and sell different amounts of points and effectively choose the line which makes the most appeal. It all comes down to how risky or safe you want to play things.

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Our Game Prediction

South Florida -21.5 @ -108 Bet Now

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Correct Score Prediction

South Florida 45 - 21 UAB

For those looking to get more bang for their buck, consider a correct score wager on the Bulls. Backing them to win 45-21 means you can land a potential monster return.

South Florida vs UAB Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

South Florida are strong -2500 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 96% chance of claiming victory. For those wanting to oppose the market leader, you can get +1200 about UAB.

The spread is currently 21.5, with the total points line at 68.5. Having a bet on the Totals is one of the most popular football wagers. There’s the chance to back Under 68.5 at -105.

Consider every angle when placing your college football wagers. The best betting sites have a huge selection of team props and game lines and it’s all about finding a bet which matches your prediction of the game.

Moneyline

USF

-2500

UAB

+1200

Point Spread

USF -21.5

-108

UAB +21.5

-112

Total Points

Under 68.5

-105

Over 68.5

-115

If you have a view on Player Interceptions, Passing Attempts or Longest Pass Completion, then the player prop betting could be up your street. It’s a great way of wagering on a player or quarterback to perform well.

Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

UAB Have Collected Five Wins From Last Ten at Home

UAB are 5-5 in their last 10 home games, putting up 31.10 points on average and giving up 35.60.

USF have gone 5-5 across their last 10 road games, putting up 34.40 points on average and giving up 34.00.

UAB defeated USF 56-35 in their last meeting at Protective Stadium.

Last 10 Games		W-L	P	PF	PA	O68.5	U68.5
UAB Home Stats		5-5	66.70	31.10	35.60	4	6
South Florida Away Stats		5-5	68.40	34.40	34.00	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O68.5 = Games Over 68.5 Points
• U68.5 = Games Under 68.5 Points

Latest regular season and playoff games stats.

South Florida Stats

UAB Blazers Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -21.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -21.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +21.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +21.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 67.50 pts in the previous 10 games
• Game Totals on the Road: An average of 68.40 pts in the previous 10 games on the road
• Over 68.5: Covered in 5 of the previous 10 games
• Over 68.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 41.60 pts and allowed 25.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 34.40 pts and allowed 34.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 65.50 pts in the previous 10 games
• Game Totals at Home: An average of 66.70 pts in the previous 10 home games
• Over 68.5: Covered in 4 of the previous 10 games
• Over 68.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 26.80 pts and allowed 38.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.10 pts and allowed 35.60 pts in the last 10 home games

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