SMU vs Clemson Prediction, Picks & Odds | 18 Oct 2025

College Football Betting Preview: SMU vs Clemson

SMU battle Clemson in this NCAAF Week 8 clash at Memorial Stadium, with kickoff scheduled for 15:30 on Saturday, October 18. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We’re delighted to see SMU have been given a headstart on the spread. Take the +5.5 at -108 when they go up against Clemson.

Backing our spread pick? Don’t forget to check out our new BetMGM promo code and in-depth site review before locking in your selection.

SMU Mustangs beat Stanford Cardinal in their previous game, making it back-to-back victories. It was a 34-10 home win at Gerald J. Ford Stadium.

Clemson Tigers won last time out by a 41-10 scoreline. On the road against Boston College Eagles at Alumni Stadium, they made it back-to-back wins.

Head-to-Head Statistics

It was a 34-31 win for Clemson at Bank of America Stadium when they last played SMU.

SMU vs Clemson Prediction & Picks

Step into SMU vs Clemson with confidence as we bring you our main match prediction, projected scoreline and a custom-built bet builder. Dive into each section below for the latest insights.

Game Prediction

We’re confident of SMU staying close in this college football matchup, with our pick being that the underdogs will cover the spread. The +5.5 line looks generous at odds of -108.

Getting the lowdown on injuries and analyzing the form guide are key steps before making CFB predictions. We also put strong emphasis on stats, where a data-led approach often leads to smarter picks.

Key SMU vs Clemson stats:

• The +5.5 line has been covered by SMU in 18 of their last 20 games.
• The +5.5 line has been covered by SMU in 5 of their last 6 games this season.
• The +5.5 line has been covered by SMU in 2 consecutive games.
• The -5.5 line hasn’t been covered by Clemson in 2 of their last 3 games at home this season.
• The -5.5 line hasn’t been covered by Clemson in 6 of their last 10 games.

SMU +5.5 Probability

Based on the odds from the top sportsbooks, our pick has a 51.8% chance of winning. After careful examination, our team calculate this probability to be closer to 60%. That means we are regarding it as a value wager.

In the hunt for bigger odds, you might be interested to know that you can move the betting line. There’s extra juice depending on how risky you want your bet to be.

Thinking of placing a bet? Make sure to check our guide first — it’s full of the latest offers and welcome bonuses worth claiming.

Our Game Prediction

SMU +5.5 @ -108 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Correct Score Prediction

SMU 20 - 24 Clemson

There might not be too much between these teams, with our correct score pick being a 24-20 victory for Clemson. There are huge odds available when it comes to this prediction.

SMU vs Clemson Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Sportsbooks’ favorites Clemson are regarded as likeliest victors for this college game and the -175 about them triumphing means a 64% chance based on their current Moneyline betting odds. SMU are regarded as a long shot to win and you can currently back them at +146.

The spread is currently 3.5, with the total points line at 49.5. The Totals offers football bettors an alternative way of getting involved. Those who wager Under 49.5 can get -110.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

SMU

+146

Clemson

-175

Point Spread

SMU +3.5

-105

Clemson -3.5

-115

Total Points

Under 49.5

-110

Over 49.5

-110

Should you be more interested in a specific individual who is competing, check out the gambling sites’ prop bets where you can pick out player and quarterback lines that focus on performance rather than the game result.

Instead of focusing on the overall outcome, some bettors prefer to look at the college football micro betting lines. As the name suggests, it means placing short-term in-game wagers and this might include the Next Play or Next Drive Result.

Clemson Have Picked Up Six Wins in Past Ten at Home

Clemson have a 6-4 record in their last 10 home games, putting up 35.70 points per contest and giving up 23.10.

SMU own a 7-3 mark in their past 10 road games, averaging 26.60 points scored and 21.50 points allowed.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Clemson Home Stats		6-4	58.80	35.70	23.10	7	3
SMU Away Stats		7-3	48.10	26.60	21.50	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Latest regular season and playoff games stats.

SMU Stats

Clemson Tigers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 53.50 pts in the previous 10 games
• Game Totals on the Road: An average of 48.10 pts in the previous 10 games on the road
• Over 50.5: Covered in 4 of the previous 10 games
• Over 50.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 31.60 pts and allowed 21.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 26.60 pts and allowed 21.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 49.20 pts in the previous 10 games
• Game Totals at Home: An average of 58.80 pts in the previous 10 home games
• Over 50.5: Covered in 5 of the previous 10 games
• Over 50.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 28.10 pts and allowed 21.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.70 pts and allowed 23.10 pts in the last 10 home games

Top American Football Pages