Southern Miss vs Louisiana Prediction, Picks & Odds | 18 Oct 2025

College Football Betting Preview: Southern Miss vs Louisiana

Southern Miss go up against Louisiana in this NCAAF Week 8 matchup at Cajun Field, with kickoff scheduled for 17:00 on Saturday, October 18. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We’ll take a chance on Louisiana who have been given a generous +3.5 on the spread. We think -108 can be taken with confidence that they cover the line against Southern Miss.

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Southern Mississippi Golden Eagles won their previous game 38-35. This road victory at Allen E. Paulson Stadium against Georgia Southern Eagles was their second on the spin.

Louisiana Ragin Cajuns have secured back-to-back home victories. Their last game was on the road and a 24-14 loss occurred against James Madison Dukes at Bridgeforth Stadium.

Head-to-Head Statistics

Louisiana won the last matchup between the pair. Enjoying a 23-13 triumph when facing Southern Miss at M.M. Roberts Stadium. The past 3 games between the teams have seen Southern Miss win two times.

Southern Miss vs Louisiana Prediction & Picks

Approach Southern Miss vs Louisiana fully prepared with our expert match prediction, likely correct score outcome and a hand-picked bet builder designed for value.

Game Prediction

We wouldn’t be surprised to see Louisiana triumph in this college football matchup. In terms of landing extra value, it makes sense to take +3.5 on the spread at -108.

Injuries are always factored in by the CFB handicappers at Sportsgambler.com. Our predictions are also shaped by recent form, with up-to-date stats playing a key role before any selections are locked in.

Key Southern Miss vs Louisiana stats:

• The +3.5 line has been covered by Louisiana in 17 of their last 20 games at home.
• The +3.5 line has been covered by Louisiana in 8 of their last 10 games at home.
• The +3.5 line has been covered by Louisiana in 3 consecutive games at home.
• The -3.5 line hasn’t been covered by Southern Miss in 14 consecutive games on the road.
• The -3.5 line hasn’t been covered by Southern Miss in 18 of their last 20 games on the road.
• The +3.5 line has been covered by Louisiana in 2 consecutive games against Southern Miss.

Louisiana +3.5 Probability

Based on the odds from the top sportsbooks, our pick has a 51.8% chance of winning. After careful examination, our experts have this probability somewhere between 55-60%. This is why we regard this as a value bet.

If you’re hunting for larger odds and feel confident your selection is going to perform well, then consider moving the line and land a bigger potential return.

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Our Game Prediction

Louisiana +3.5 @ -108 Bet Now

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Correct Score Prediction

Southern Miss 28 - 30 Louisiana

We’re expecting a close battle so it might be worth going for Louisiana to triumph by a 30-28 scoreline. You can get a massive price and we should hopefully get a run for our money.

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Southern Miss vs Louisiana Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The sportsbooks have Southern Miss at -167 when it comes to the Moneyline betting, implying the market leaders are 63% likely to win this college game according to the latest odds. If you’re looking for an alternative angle, Louisiana are trading at +140.

The spread is currently 3.5, with the total points line at 54.5. Football bettors regularly enjoy the opportunity to wager on the Totals. If you fancy Under 54.5, then the odds are -110.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Moneyline

Southern Miss

-167

Louisiana

+140

Point Spread

Southern Miss -3.5

-110

Louisiana +3.5

-110

Total Points

Under 54.5

-110

Over 54.5

-110

As an alternative to the game lines, check out the quarterback and player props that are available. These can be a great alternative if you want to focus on a player’s performance. The gambling sites will provide lots of options.

Micro betting is an exciting way to wager on college football. There are a huge range of live lines and it’s a simple case of predicting what is going to happen next. Field Goal Outcome, Next Drive Result and Next Play Result are often among the options.

Last Ten Home Games Have Produced Six Wins for Louisiana

Louisiana are 6-4 in their last 10 home games, averaging 33.80 points on offense and surrendering 25.40 on defense.

Southern Miss own a 2-8 mark in their past 10 road games, averaging 17.80 points scored and 39.20 points allowed.

The last time the teams met at Cajun Field, Southern Miss defeated Louisiana 34-31.

Last 10 Games		W-L	P	PF	PA	O54.5	U54.5
Louisiana Home Stats		6-4	59.20	33.80	25.40	5	5
Southern Miss Away Stats		2-8	57.00	17.80	39.20	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O54.5 = Games Over 54.5 Points
• U54.5 = Games Under 54.5 Points

Latest regular season and playoff games stats.

Southern Mississippi Golden Eagles Stats

Louisiana Ragin Cajuns Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -3.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -3.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

• +3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +3.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 58.10 pts in the previous 10 games
• Game Totals on the Road: An average of 57.00 pts in the previous 10 games on the road
• Over 54.5: Covered in 6 of the previous 10 games
• Over 54.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 23.30 pts and allowed 34.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.80 pts and allowed 39.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.20 pts in the previous 10 games
• Game Totals at Home: An average of 59.20 pts in the previous 10 home games
• Over 54.5: Covered in 5 of the previous 10 games
• Over 54.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 24.90 pts and allowed 30.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 33.80 pts and allowed 25.40 pts in the last 10 home games

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