Southern Miss vs South Alabama Prediction, Picks & Odds | 22 Nov 2025
College Football Betting Preview: Southern Miss vs South Alabama
Southern Miss battle South Alabama at Hancock Whitney Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.
If you are looking for a value wager, then -120 that Southern Miss beat South Alabama certainly stands out. We’re expecting them to win on the Moneyline and there are attractive odds available.
Feeling good about Southern Miss? Read what we say about BetMGM in our detailed review, then grab the newest bonus promo code for extra value.
Southern Mississippi Golden Eagles have won three straight road games. Most recently, they lost 41-14 at home to Texas State Bobcats at M.M. Roberts Stadium.
South Alabama Jaguars have lost four straight home games. In their last appearance, they won on the road, beating Louisiana-Monroe Warhawks 26-14 at Malone Stadium.
Head-to-Head Statistics
The last head-to-head saw South Alabama claim a 35-14 win over Southern Miss at M.M. Roberts Stadium. In the past 5 meetings between these teams, South Alabama have won all of them.
Southern Miss vs South Alabama Prediction & Picks
Our Southern Miss vs South Alabama tips include the main match prediction, a correct score forecast and bet builder picks. Each section below offers expert insight into the key betting angles.
Game Prediction
There’s -120 available when it comes to Southern Miss on the Moneyline. We believe that our pick has a strong chance of winning this college football matchup and the odds makes plenty of appeal.
Our CFB handicappers start by reviewing the latest team news for each team, followed by a close look at recent form. That information is then applied to the most relevant stats to reach a well-informed verdict.
Key Southern Miss vs South Alabama stats:
Southern Miss Moneyline Probability
According to the latest betting odds, our pick has a 54.6% chance of winning. After careful examination, our cappers have this probability close to 60%. This college bet can therefore be backed with confidence.
If you’re looking for a bet at bigger odds, then Southern Miss are an option on the spread. The top sportsbooks have a series of lines that you can back them to cover.
Ready to wager? First, explore top-tier betting promo codes, free bets, and welcome bonuses with our expert bonus guide.
Same Game Parlay Picks
Get in the game with this same game parlay. Our selections are Southern Miss on the moneyline, Under 53.5 on the total and Touchdown as first score method.
The same game parlay option allows you to combine different outcomes within the same game. You need all your predictions to be correct although bettors love to place a tailored football bet on the event which interests them most.
Correct Score Prediction
28
-
21
South Alabama
Should you wish to go for a speculative bet, try Southern Miss to triumph 28-21 on the correct score lines. This should be a fun wager which could potentially yield a huge return.
Southern Miss vs South Alabama Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
We’re seeing South Alabama priced up at -106 for a victory, with Southern Miss trading at -110. The leading sportsbooks give the hosts a 52% chance of success.
The spread is 1.5 and the total points line is currently 53.5. The beauty of the Totals is that you only have to choose from one of two options. Those expecting a low total can back Under 53.5 at -115.
College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.
The gambling sites will have quarterback and player props available for each game. Check out the various betting lines and take a view on whether a player’s Passing Yards or Receiving Yards will be above or below a certain amount.
An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.
South Alabama With Four Consecutive Home Losses
South Alabama are winless in their last four at Hancock Whitney Stadium. They are 4-6 in their last 10 home games, averaging 35.10 points scored and 25.30 points allowed.
Southern Miss have strung together three consecutive road wins. They own a 3-7 mark in their past 10 road games, posting 17.30 points per contest while yielding 35.10.
The previous meeting at Hancock Whitney Stadium saw South Alabama defeat Southern Miss 55-3.
| Last 10 Games | W-L | P | PF | PA | O53.5 | U53.5 | |
|---|---|---|---|---|---|---|---|
 South Alabama Home Stats |
4-6 | 60.40 | 35.10 | 25.30 | 7 | 3 | |
 Southern Miss Away Stats |
3-7 | 52.40 | 17.30 | 35.10 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O53.5 = Games Over 53.5 Points
- U53.5 = Games Under 53.5 Points
Latest regular season and playoff games stats.
Southern Mississippi Golden Eagles Stats
South Alabama Jaguars Stats
- 7 wins and 3 defeats in the last 10 games
- 3 wins and 7 defeats in the last 10 games on the road
- -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -1.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road
- +1.5 Betting Line: Have covered the spread in 4 of the last 10 games
- +1.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 56.40 pts in the previous 10 games
- Game Totals on the Road: An average of 52.40 pts in the previous 10 games on the road
- Over 53.5: Covered in 6 of the previous 10 games
- Over 53.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 30.50 pts and allowed 25.90 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 17.30 pts and allowed 35.10 pts in the last 10 games on the road
- Game Totals: An average of 53.10 pts in the previous 10 games
- Game Totals at Home: An average of 60.40 pts in the previous 10 home games
- Over 53.5: Covered in 6 of the previous 10 games
- Over 53.5 at Home: Covered in 7 of the previous 10 home games
- Team Totals: Have scored an average of 25.00 pts and allowed 28.10 pts in the last 10 games
- Team Totals at Home: Have scored an average of 35.10 pts and allowed 25.30 pts in the last 10 home games
| Sun Belt | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
James Madison
|
12 | 1 | 485 | 206 | 279 | 7-0 | 5-1 | 11W |
Old Dominion
|
9 | 3 | 392 | 231 | 161 | 6-0 | 3-3 | 5W |
Troy
|
8 | 5 | 316 | 318 | -2 | 4-2 | 4-3 | 1L |
|
Southern Miss
|
7 | 5 | 358 | 329 | 29 | 4-3 | 3-2 | 3L |
Coastal Carolina
|
6 | 6 | 274 | 407 | -133 | 4-2 | 2-4 | 3L |
Arkansas State
|
6 | 6 | 293 | 328 | -35 | 3-3 | 3-3 | 1W |
Louisiana
|
6 | 6 | 325 | 360 | -35 | 4-2 | 2-4 | 4W |
Georgia Southern
|
6 | 6 | 334 | 410 | -76 | 4-2 | 2-4 | 1W |
Texas State
|
6 | 6 | 433 | 367 | 66 | 4-2 | 2-4 | 3W |
Marshall
|
5 | 7 | 369 | 363 | 6 | 3-3 | 2-4 | 2L |
Appalachian State
|
5 | 7 | 304 | 358 | -54 | 3-3 | 2-4 | 1L |
|
South Alabama
|
4 | 8 | 318 | 365 | -47 | 2-4 | 2-4 | 1L |
UL Monroe
|
3 | 9 | 199 | 383 | -184 | 2-3 | 1-6 | 8L |
Georgia State
|
1 | 11 | 237 | 454 | -217 | 1-5 | 0-6 | 9L |
Metaloglobus
Csikszereda
Predictions
11:00 - Wed 04 Feb
SuperLiga
UTA Arad
CFR Cluj
Predictions
11:30 - Wed 04 Feb
Super League Greece
Asteras Tripolis
Olympiacos
Predictions
12:00 - Wed 04 Feb
EuroCup
Besiktas
Turk Telekom
Predictions
12:00 - Wed 04 Feb
EuroCup
Lietkabelis
Panionios
Predictions
13:00 - Wed 04 Feb
EuroCup
Hapoel Jerusalem
Cluj-Napoca
Predictions