Southern Miss vs South Alabama Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Southern Miss vs South Alabama

Southern Miss battle South Alabama at Hancock Whitney Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.

If you are looking for a value wager, then -120 that Southern Miss beat South Alabama certainly stands out. We’re expecting them to win on the Moneyline and there are attractive odds available.

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Southern Mississippi Golden Eagles have won three straight road games. Most recently, they lost 41-14 at home to Texas State Bobcats at M.M. Roberts Stadium.

South Alabama Jaguars have lost four straight home games. In their last appearance, they won on the road, beating Louisiana-Monroe Warhawks 26-14 at Malone Stadium.

Head-to-Head Statistics

The last head-to-head saw South Alabama claim a 35-14 win over Southern Miss at M.M. Roberts Stadium. In the past 5 meetings between these teams, South Alabama have won all of them.

Southern Miss vs South Alabama Prediction & Picks

Our Southern Miss vs South Alabama tips include the main match prediction, a correct score forecast and bet builder picks. Each section below offers expert insight into the key betting angles.

Game Prediction

There’s -120 available when it comes to Southern Miss on the Moneyline. We believe that our pick has a strong chance of winning this college football matchup and the odds makes plenty of appeal.

Our CFB handicappers start by reviewing the latest team news for each team, followed by a close look at recent form. That information is then applied to the most relevant stats to reach a well-informed verdict.

Key Southern Miss vs South Alabama stats:

• Southern Miss have won 4 of their last 5 games.
• Southern Miss have won 7 of their last 10 games.
• Southern Miss have won 3 consecutive games on the road.
• South Alabama have lost their last 4 games at home.
• South Alabama have lost 7 of their last 10 games.
• South Alabama have lost 11 of their last 20 games.

Southern Miss Moneyline Probability

According to the latest betting odds, our pick has a 54.6% chance of winning. After careful examination, our cappers have this probability close to 60%. This college bet can therefore be backed with confidence.

If you’re looking for a bet at bigger odds, then Southern Miss are an option on the spread. The top sportsbooks have a series of lines that you can back them to cover.

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Our Game Prediction

Southern Miss Moneyline @ -120 Bet Now

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Correct Score Prediction

Southern Miss 28 - 21 South Alabama

Should you wish to go for a speculative bet, try Southern Miss to triumph 28-21 on the correct score lines. This should be a fun wager which could potentially yield a huge return.

Southern Miss vs South Alabama Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

We’re seeing South Alabama priced up at +102 for a victory, with Southern Miss trading at -120. The leading sportsbooks give the hosts a 50% chance of success.

The spread is 1.5 and the total points line is currently 53.5. The beauty of the Totals is that you only have to choose from one of two options. Those expecting a low total can back Under 53.5 at -110.

College football bettors are spoilt for choice thanks to the huge selection of team props and game lines which are available for every matchup on the coupon. Head to the top sportsbooks and find the best value wagers.

Moneyline

Southern Miss

-120

South Alabama

+102

Point Spread

Southern Miss -1.5

-112

South Alabama +1.5

-108

Total Points

Under 53.5

-110

Over 53.5

-110

The gambling sites will have quarterback and player props available for each game. Check out the various betting lines and take a view on whether a player’s Passing Yards or Receiving Yards will be above or below a certain amount.

An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

South Alabama With Four Consecutive Home Losses

South Alabama are winless in their last four at Hancock Whitney Stadium. They are 4-6 in their last 10 home games, averaging 35.10 points scored and 25.30 points allowed.

Southern Miss have strung together three consecutive road wins. They own a 3-7 mark in their past 10 road games, posting 17.30 points per contest while yielding 35.10.

The previous meeting at Hancock Whitney Stadium saw South Alabama defeat Southern Miss 55-3.

Last 10 Games		W-L	P	PF	PA	O53.5	U53.5
South Alabama Home Stats		4-6	60.40	35.10	25.30	7	3
Southern Miss Away Stats		3-7	52.40	17.30	35.10	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O53.5 = Games Over 53.5 Points
• U53.5 = Games Under 53.5 Points

Latest regular season and playoff games stats.

Southern Mississippi Golden Eagles Stats

South Alabama Jaguars Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -1.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -1.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +1.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +1.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 56.40 pts in the previous 10 games
• Game Totals on the Road: An average of 52.40 pts in the previous 10 games on the road
• Over 53.5: Covered in 6 of the previous 10 games
• Over 53.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.50 pts and allowed 25.90 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.30 pts and allowed 35.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.10 pts in the previous 10 games
• Game Totals at Home: An average of 60.40 pts in the previous 10 home games
• Over 53.5: Covered in 6 of the previous 10 games
• Over 53.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 25.00 pts and allowed 28.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.10 pts and allowed 25.30 pts in the last 10 home games

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