Stanford vs Virginia Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: Stanford vs Virginia

Stanford square off against Virginia in this NCAAF Week 4 matchup at Scott Stadium, with kickoff scheduled for 19:30 on Saturday 20 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Virginia Look Far Too Strong

We’d be surprised if Virginia don’t exceed a -15.5 spread against Stanford. That is why the bet has to be for them to cover the line at -115.

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Each Team Bidding to Secure Another Win

Stanford Cardinal have lost their previous two on the road. Their most recent game was at home at Stanford Stadium where they recorded a 30-20 victory over Boston College Eagles.

Virginia Cavaliers won their last game 55-16, making it back-to-back home wins. This was recorded at Scott Stadium against William & Mary Tribe.

Stanford vs Virginia Prediction & Picks

This Stanford vs Virginia betting breakdown features a main match prediction, a correct score insight and a sharply constructed bet builder to guide your wagers.

Game Prediction

Our pick is that Virginia will get the better of their opponents by a significant margin in this college football matchup. With this in mind, let’s go for the favorites at -15.5 on the spread which is currently available at odds of -115.

Incoming team news often impacts the betting lines and odds in significant ways. Our college football handicappers factor this in alongside recent form, while key stats are also carefully weighed to strengthen each pick.

Key Stanford vs Virginia stats:

• The -15.5 line has been covered by Virginia in 2 consecutive games at home.
• The +15.5 line hasn’t been covered by Stanford in 11 of their last 20 games on the road.

Virginia -15.5 Probability

According to the best betting apps, our pick has a 53.5% chance of winning. Taking all factors into consideration, our cappers think there’s a stronger chance of success and estimate the probability to be closer to 60%. It's why we think it’s worth placing this college wager.

If you want to land a big potential return from a small stake, then a Bet Builder could be a good way to go. Back Virginia against the spread in a combination with other picks.

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Best Bet

Virginia -15.5 @ -115 Bet Now

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Correct Score Prediction

Stanford 17 - 38 Virginia

There’s the chance to land massive odds when it comes to a Virginia correct score win. We’ll try a 38-17 victory in their favor and this should be in the right ball park.

Stanford vs Virginia Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Virginia Heavy Favorites to Win

Virginia have short betting odds and they’re overwhelming -833 favorites for this college game. This means the sportsbooks give them a 89% chance of winning. The market suggests that Stanford are least likely to win at +570.

The spread currently stands at 15.5 and the total points line is 48.5. Having a bet on the Totals is one of the most popular football wagers. Those expecting a low total can back Under 48.5 at -110.

The top sportsbooks offer a huge selection of team props and game lines when it comes to most college football games. Make sure you look through all the available options before deciding which bet to place.

Moneyline

Stanford

+570

Virginia

-833

Point Spread

Stanford +15.5

-105

Virginia -15.5

-115

Total Points

Under 48.5

-110

Over 48.5

-110

Player Props & Micro Betting

We’re fond of the quarterback and player props as an alternative to betting on the game lines. The gambling sites will have Player Kicking Points, Longest Rushing Attempt and Rushing Yards among the choices and you can take a view.

Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

Virginia With Five Wins in Past Ten Home Games

Virginia own a 5-5 mark in their past 10 home games, putting up 26.20 points per contest and giving up 25.70.

Stanford have suffered seven consecutive road defeats. They have gone 2-8 across their last 10 road games, posting 17.70 points per contest while yielding 34.90.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Virginia Home Stats		5-5	51.90	26.20	25.70	5	5
Stanford Away Stats		2-8	52.60	17.70	34.90	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Stanford Cardinal Stats

Virginia Cavaliers Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +15.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +15.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -15.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -15.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 55.00 pts in the previous 10 games
• Game Totals on the Road: An average of 52.60 pts in the previous 10 games on the road
• Over 48.5: Covered in 7 of the previous 10 games
• Over 48.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 21.20 pts and allowed 33.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 17.70 pts and allowed 34.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.60 pts in the previous 10 games
• Game Totals at Home: An average of 51.90 pts in the previous 10 home games
• Over 48.5: Covered in 7 of the previous 10 games
• Over 48.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 26.10 pts and allowed 29.50 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.20 pts and allowed 25.70 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
California	3	0	96	32	64	2-0	1-0	3W
Florida State	2	0	108	20	88	2-0	0-0	2W
Georgia Tech	3	0	110	53	57	2-0	1-0	3W
Louisville	2	0	79	31	48	2-0	0-0	2W
Miami	3	0	121	39	82	3-0	0-0	3W
NC State	3	0	93	72	21	2-0	1-0	3W
Wake Forest	2	1	76	53	23	2-1	0-0	1L
Virginia	2	1	134	58	76	2-0	0-1	1W
SMU	2	1	115	71	44	1-1	1-0	1W
Syracuse	2	1	119	89	30	2-0	0-1	2W
Pittsburgh	2	1	130	57	73	2-0	0-1	1L
North Carolina	2	1	75	57	18	1-1	1-0	2W
Boston College	1	2	126	82	44	1-0	0-2	2L
Clemson	1	2	58	57	1	1-1	0-1	1L
Duke	1	2	91	96	-5	1-1	0-1	2L
Stanford	1	2	53	70	-17	1-0	0-2	1W
Virginia Tech	0	3	57	113	-56	0-2	0-1	3L