Syracuse vs Clemson Prediction, Picks & Odds | 20 Sep 2025
College Football Betting Preview: Syracuse vs Clemson
Syracuse square off against Clemson in this NCAAF Week 4 matchup at Memorial Stadium, with kickoff scheduled for 12:00 on Saturday, September 20. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.
Our prediction is that Syracuse might not be beaten heavily by Clemson. The underdogs have been afforded a generous +16.5 and we recommend backing them at odds of -102.
Syracuse Orange claimed a home victory in their previous game. A 66-24 triumph against Colgate Raiders at JMA Wireless Dome made it back-to-back wins.
Clemson Tigers suffered a defeat in their last game. A 24-21 scoreline occurred on the road at Bobby Dodd Stadium against Georgia Tech Yellow Jackets.
Head-to-Head Statistics
Clemson beat Syracuse when the teams last met. It was a 31-14 scoreline at JMA Wireless Dome. In the past 5 meetings between these teams, Clemson have won all of them.
Quarterbacks
Steve Angeli
Cade Klubnik
Syracuse vs Clemson Prediction & Picks
From our key match prediction to correct score pick, top player prop insights and a builder tailored for value — our Syracuse vs Clemson betting tips covers it all.
Game Prediction
It’s all about Syracuse to stay ahead of the curve against the favorites. We really like this wager and the +16.5 spread looks generous at odds of -102 for this college football battle.
Sportsgambler.com brings strong college football expertise, built on knowing the team news as soon as it’s confirmed. Recent form plays a big part in our CFB picks and we always back it up with the most relevant stats.
Key Syracuse vs Clemson stats:
Syracuse +16.5 Probability
According to the top sportsbooks, our pick has a 50.5% chance of delivering a return. Our experts think there’s a stronger chance of success and calculate the probability to be 55-60%. This is why we regard this as a value wager.
There’s the option to move the line for your point spread pick and this enables bettors to get bigger odds. If you’re prepared for additional risk, you can get more bang for your buck.
Elevate your wagering experience with the latest free bets, promos and top betting offers listed in our comprehensive bonus guide.
Player Prop Picks
The odds for Cade Klubnik (Clemson) to record fewer than 264.5 passing yards stand at -114. He is likely to fall short of the line, making this QB Passing Yards bet an appealing option.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Try out our same game parlay pick which starts with Syracuse +16.5. We’ve also gone for Over 55.5 points and Cade Klubnik (Clemson) to go Under 264.5 passing yards.
A football same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big return from a small stake.
Correct Score Prediction
27
-
34
Clemson
There are lots of different betting angles including the chance to bet on Clemson on the correct score lines. For example, a 34-27 win in their favor is available at huge odds.
Syracuse vs Clemson Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
The favorites are 90% likely to win according to the sportsbooks’ latest Money Line odds, with Clemson priced at -909 to triumph in this college game. For those wanting to oppose the market leader, you can get +580 about Syracuse.
The current spread is 16.5 and total points is 54.5. Having a bet on the Totals is one of the most popular football wagers. There’s the chance to back Under 54.5 at -112.
You’ll find a great variety of team props and game lines for most college football showdowns. The best betting apps provide a strong mix of pre-game and in-game options to suit your betting style.
The Anytime Touchdown betting indicates that Adam Randall has odds of %anytime_odds%. He is available at %first_odds% to score the first TD which makes him favorite.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.
Last Ten Home Games Have Produced Seven Wins for Clemson
Clemson are 7-3 in their last 10 home games, averaging 36.70 points scored and 21.70 points allowed.
Syracuse have a 4-6 record in their last 10 road games, scoring 25.80 points per contest and conceding 35.10.
Clemson beat Syracuse 27-21 when they last met at Memorial Stadium.
| Last 10 Games | W-L | P | PF | PA | O55.5 | U55.5 | |
|---|---|---|---|---|---|---|---|
 Clemson Home Stats |
7-3 | 58.40 | 36.70 | 21.70 | 4 | 6 | |
 Syracuse Away Stats |
4-6 | 60.90 | 25.80 | 35.10 | 5 | 5 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O55.5 = Games Over 55.5 Points
- U55.5 = Games Under 55.5 Points
Latest regular season and playoff games stats.
Syracuse Orange Stats
Clemson Tigers Stats
- 7 wins and 3 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +16.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +16.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road
- -16.5 Betting Line: Have covered the spread in 1 of the last 10 games
- -16.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 67.90 pts in the previous 10 games
- Game Totals on the Road: An average of 60.90 pts in the previous 10 games on the road
- Over 55.5: Covered in 7 of the previous 10 games
- Over 55.5 on the Road: Covered in 5 of the previous 10 games on the road
- Team Totals: Have scored an average of 35.90 pts and allowed 32.00 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 25.80 pts and allowed 35.10 pts in the last 10 games on the road
- Game Totals: An average of 47.40 pts in the previous 10 games
- Game Totals at Home: An average of 58.40 pts in the previous 10 home games
- Over 55.5: Covered in 3 of the previous 10 games
- Over 55.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 25.00 pts and allowed 22.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 36.70 pts and allowed 21.70 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Virginia
|
10 | 3 | 418 | 267 | 151 | 6-2 | 4-1 | 1L |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
Duke
|
8 | 5 | 442 | 373 | 69 | 3-3 | 5-2 | 3W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
|
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
|
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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