Syracuse vs Notre Dame Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: Syracuse vs Notre Dame

Syracuse square off against Notre Dame at Notre Dame Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.

We like the look of Syracuse +35.5 when they take on Notre Dame at odds of -105. We think the underdogs can put up a strong showing against their opponents.

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Syracuse Orange have been defeated in their previous six games. On the road, they recently suffered a 38-10 loss against Miami Hurricanes at Hard Rock Stadium.

Notre Dame Fighting Irish won their last game 37-15, making it eight on the bounce. This was a road victory at Acrisure Stadium against Pittsburgh Panthers.

Head-to-Head Statistics

The scoreline was 41-24 in favor of Notre Dame when they last played Syracuse, with the matchup taking place at JMA Wireless Dome.

Syracuse vs Notre Dame Prediction & Picks

Approach Syracuse vs Notre Dame fully prepared with our expert match prediction, likely correct score outcome and a hand-picked bet builder designed for value.

Game Prediction

We’re expecting Syracuse to keep the scoreline respectable in this college football showdown. The spread of +35.5 looks generous at odds of -105.

The handicappers at Sportsgambler.com stay on top of the latest injuries, while recent form also shapes our CFB predictions. We combine this insight with up-to-date stats for sharper picks

Key Syracuse vs Notre Dame stats:

• The +35.5 line has been covered by Syracuse in 20 consecutive games.
• The -35.5 line hasn’t been covered by Notre Dame in 9 of their last 10 games at home.
• The -35.5 line hasn’t been covered by Notre Dame in 5 of their last 6 games at home this season.

Syracuse +35.5 Probability

Based on the odds from the top sportsbooks, our pick has a 51.3% chance of winning. Our experts think there’s a stronger chance of success and calculate the probability to be closer to 60%. It’s why we think it’s worth placing this college bet.

There’s an opportunity to secure bigger odds and this can be achieved by moving the line. Squeeze more juice from your pick by taking an alternative wagering view.

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Our Game Prediction

Syracuse +35.5 @ -105 Bet Now

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Correct Score Prediction

Syracuse 14 - 41 Notre Dame

Correct score betting might be tough to predict but there’s a tasty potential return if you get it right. We’ll try the Irish to achieve a 41-14 victory at massive odds.

Syracuse vs Notre Dame Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

There’s an absence of Moneyline odds for this college game due to it being perceived as one-sided, although underdogs Syracuse and their opponents are available as options on the spread.

There is a spread of 35.5 and total points has a line of 50.5. A wager on the Totals allows football bettors to use the latest data to good effect. If you fancy Under 50.5, then the odds are -105.

When it comes to college football, the top betting apps deliver a wide variety of game lines and team props. With so many options available, it’s worth taking your time to find the wager that fits your view of the matchup.

Moneyline

Syracuse

-

Notre Dame

-

Point Spread

Syracuse +35.5

-105

Notre Dame -35.5

-115

Total Points

Under 50.5

-105

Over 50.5

-115

The gambling sites will have quarterback and player props available for each game. Check out the various betting lines and take a view on whether a player’s Passing Yards or Receiving Yards will be above or below a certain amount.

For those looking to enjoy a thrilling in-game wager, then college football micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.

Can Notre Dame Keep Their Home Form Going?

Notre Dame are riding five straight wins at Notre Dame Stadium. They have a 9-1 record in their last 10 home games, averaging 40.60 points on offense and surrendering 16.70 on defense.

Syracuse are riding a skid of three consecutive road defeats. They own a 4-6 mark in their past 10 road games, averaging 25.70 points on offense and surrendering 33.10 on defense.

When the teams last met at Notre Dame Stadium, Notre Dame beat Syracuse 45-21.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Notre Dame Home Stats		9-1	57.30	40.60	16.70	6	4
Syracuse Away Stats		4-6	58.80	25.70	33.10	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Latest regular season and playoff games stats.

Syracuse Orange Stats

Notre Dame Fighting Irish Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +35.5 Betting Line: Have covered the spread in the last 10 games
• +35.5 Betting Line on the Road: Have covered the spread in the last 10 games on the road

Point Spread

• -35.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -35.5 Betting Line at Home: Have covered the spread in 1 of the last 10 home games

Total Points

• Game Totals: An average of 53.80 pts in the previous 10 games
• Game Totals on the Road: An average of 58.80 pts in the previous 10 games on the road
• Over 50.5: Covered in 4 of the previous 10 games
• Over 50.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 22.30 pts and allowed 31.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.70 pts and allowed 33.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 56.90 pts in the previous 10 games
• Game Totals at Home: An average of 57.50 pts in the previous 10 home games
• Over 50.5: Covered in 7 of the previous 10 games
• Over 50.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 38.50 pts and allowed 18.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 37.70 pts and allowed 19.80 pts in the last 10 home games

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