Syracuse vs SMU Prediction, Picks & Odds | 04 Oct 2025

College Football Betting Preview: Syracuse vs SMU

Syracuse meet SMU in this NCAAF Week 6 matchup at Gerald J. Ford Stadium, with kickoff scheduled for 15:30 on Saturday 4 October. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Go Over the Total and Cheer on Points

We’re expecting Over 57.5 points to be scored by SMU and Syracuse combined. There’s an attractive -105 for our prediction and we’re anticipating that the scoreboard will tick over.

Feeling our Totals pick? Give our comprehensive BetMGM review a read, then grab the latest promo code before placing your bet.

Two Teams Defeated in Last Game

Syracuse Orange were defeated in their previous game. They were beaten at home to Duke Blue Devils by a 38-3 scoreline at JMA Wireless Dome.

SMU Mustangs were defeated in their last game. On the road, they suffered a 35-24 reverse against Texas Christian Horned Frogs at Amon G. Carter Stadium.

Syracuse vs SMU Prediction & Picks

Make the most of Syracuse vs SMU with our betting analysis that includes an expert match prediction, expected scoreline and a hand-picked bet builder designed for value.

Game Prediction

We’re forecasting that the two teams will produce a significant combined points total in this college football showdown. Therefore, our pick is to take the -105 that there are Over 57.5 points.

Recent form is always part of the equation and we combine it with team news as soon as it’s available. To deliver expert predictions, our college football handicappers also analyze the latest stats to ensure we’re working with the best information possible.

Key Syracuse vs SMU stats:

• The 57.5 line has been covered in 4 of the last 5 Syracuse games on the road.
• The 57.5 line has been covered in 6 of the last 10 Syracuse games.
• The 57.5 line has been covered in 7 of the last 10 SMU games at home.
• The 57.5 line has been covered in 14 of the last 20 SMU games at home.

Over 57.5 Probability

According to the best betting apps, there’s a 51.3% chance that our pick is settled as a winner. In the opinion of our analysts, there’s actually a probability of success between 55-60%. That means we are regarding it as a value wager.

In order to land bigger odds on your Overs bet, it’s possible to combine this with the winning team. The Result & Total lines can provide a larger potential payout.

Discover top betting offers to power your next wager, including free bets, welcome bonuses, and exciting new promos.

Best Bet

Over 57.5 Points @ -105 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Correct Score Prediction

Syracuse 24 - 38 SMU

There are lots of different ways to back the Mustangs on the correct score betting and something like 38-24 in their favor might be along the right lines at massive odds.

Syracuse vs SMU Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

SMU Big Favorites on the Moneyline

The favorites are 89% likely to win according to the sportsbooks’ latest Money Line odds, with SMU priced at -833 to triumph in this college game. At +590, Syracuse are regarded as having a lower probability of winning.

17.5 is the spread and 57.5 is the total points line. Having a bet on the Totals is one of the most popular football wagers. If you want to wager Over 57.5, there are odds of -105.

Make sure to explore all angles before placing your college football bets. The top sportsbooks offer a wide range of game lines and team props and it’s all about finding a wager which matches your prediction of the matchup.

Moneyline

Syracuse

+590

SMU

-833

Point Spread

Syracuse +17.5

-114

SMU -17.5

-106

Total Points

Under 57.5

-115

Over 57.5

-105

Player Props & Micro Betting

The gambling sites also allow you to place player prop bets such as Quarterback Passing Yards and First/Last Touchdown Scorer. This means you can focus on an individual player’s performance rather than wager on the actual outcome of the game in question.

Micro betting is something that’s really popular with bettors, with college football fans essentially being able to wager in-game when it comes to score, player and team props. Sometimes these are two-way lines where you can bet on the Next Play or Next Drive.

SMU Hold Eight Wins From Last Ten at Home

SMU own a 8-2 mark in their past 10 home games, putting up 45.20 points per contest and giving up 21.70.

Syracuse have five wins and five losses in the last 10 road games, averaging 28.90 points on offense and surrendering 33.10 on defense.

Last 10 Games		W-L	P	PF	PA	O57.5	U57.5
SMU Home Stats		8-2	66.90	45.20	21.70	7	3
Syracuse Away Stats		5-5	62.00	28.90	33.10	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O57.5 = Games Over 57.5 Points
• U57.5 = Games Under 57.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Syracuse Orange Stats

SMU Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +17.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +17.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -17.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -17.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 65.20 pts in the previous 10 games
• Game Totals on the Road: An average of 62.00 pts in the previous 10 games on the road
• Over 57.5: Covered in 6 of the previous 10 games
• Over 57.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 34.50 pts and allowed 30.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 28.90 pts and allowed 33.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 58.10 pts in the previous 10 games
• Game Totals at Home: An average of 66.10 pts in the previous 10 home games
• Over 57.5: Covered in 5 of the previous 10 games
• Over 57.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 33.70 pts and allowed 24.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 42.40 pts and allowed 23.70 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	W	L	PF	PA	N. Pts	Home	Away	Strk
Georgia Tech	5	0	185	106	79	3-0	2-0	5W
Louisville	4	0	153	75	78	3-0	1-0	4W
Miami	4	0	147	46	101	4-0	0-0	4W
California	4	1	124	90	34	2-0	2-1	1W
Virginia	4	1	228	116	112	4-0	0-1	3W
Florida State	3	1	212	76	136	3-0	0-1	1L
Syracuse	3	2	156	148	8	2-1	1-1	1L
NC State	3	2	147	140	7	2-1	1-1	2L
Duke	3	2	174	132	42	2-1	1-1	2W
North Carolina	2	2	84	91	-7	1-1	1-1	1L
Pittsburgh	2	2	157	91	66	2-1	0-1	2L
SMU	2	2	139	106	33	1-1	1-1	1L
Wake Forest	2	2	105	83	22	2-2	0-0	2L
Stanford	2	3	103	147	-44	2-0	0-3	1W
Virginia Tech	2	3	118	140	-22	1-2	1-1	2W
Boston College	1	3	150	110	40	1-1	0-2	3L
Clemson	1	3	79	91	-12	1-2	0-1	2L