UConn vs Buffalo Prediction, Picks & Odds | 27 Sep 2025

College Football Betting Preview: UConn vs Buffalo

UConn go up against Buffalo in this NCAAF Week 5 matchup at University of Buffalo Stadium, with kickoff scheduled for 15:30 on Saturday 27 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

UConn and Buffalo to Play Out High-Scoring Game

You can get -110 that there are Over 50.5 points and there’s plenty of juice in those odds. Buffalo and UConn should be able to keep the score ticking for our prediction to win.

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UConn 47-3 Victors When Teams Met Last

UConn Huskies have experienced back-to-back road defeats. In their previous game, they beat Ball State Cardinals at home, winning 31-25 at Rentschler Field.

Buffalo Bulls lost when they last took to the field. At University of Buffalo Stadium, they were turned over 21-17 at home to Troy State Trojans.

Head-to-Head Statistics

The last matchup between UConn and Buffalo saw the former win. It was a 47-3 scoreline at Rentschler Field.

UConn vs Buffalo Prediction & Picks

The UConn vs Buffalo betting tips feature sharp analysis across major markets, including a key match prediction, correct score guidance and a ready-made bet builder.

Game Prediction

These teams are capable of scoring more than 50.5 points in this college football matchup. Therefore, we’re going Over the total line and expect a payout at -110.

Injuries can influence the outcome and our CFB handicappers factor that in alongside the latest form guide. We apply the same approach to the stats to build the clearest picture of how the matchup might unfold.

Key UConn vs Buffalo stats:

• The 50.5 line has been covered in 3 of the last 4 UConn games this season.
• The 50.5 line has been covered in 7 of the last 10 UConn games.
• The 50.5 line has been covered in the last 2 UConn games.
• The 50.5 line has been covered in 3 of the last 5 Buffalo games at home.
• The 50.5 line has been covered in 6 of the last 10 Buffalo games.

Over 50.5 Probability

If you go by the best sportsbooks, our pick has a 52.4% prospect of winning. Our cappers think there’s a stronger chance of success and calculate the probability to be 55-60%. It's why we think it’s worth placing this college wager.

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Best Bet

Over 50.5 Points @ -110 Bet Now

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Correct Score Prediction

UConn 24 - 30 Buffalo

Let’s roll the dice and try the Bulls to achieve a 30-24 winning scoreline here. There are huge odds for this potential outcome and it’s a fun type of bet to enjoy.

UConn vs Buffalo Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Make UConn Moneyline Favorites

The UConn odds have been priced up by the sportsbooks and they are -172 betting favorites to land victory in this college game which means a 63% chance of winning. The market suggests that Buffalo are least likely to win at +142.

The current spread is 3.5 and the total points line is 50.5. Football fans love the chance to get an alternative angle by going for a Total wager. If you're keen on Over 50.5, this selection is available at -102.

When it comes to college football, the top betting apps deliver a wide variety of game lines and team props. With so many options available, it’s worth taking your time to find the wager that fits your view of the matchup.

Moneyline

UConn

-172

Buffalo

+142

Point Spread

UConn -3.5

-112

Buffalo +3.5

-108

Total Points

Under 50.5

-120

Over 50.5

-102

Player Props & Micro Betting

If you’re looking for an alternative to the main game lines, check out the player props instead. It’s great to bet on Quarterback Passing Yards, First Touchdown Scorer and Passing Touchdowns as potential options.

You don’t have to wait for the final outcome when it comes to college football micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Buffalo Sitting on Six Wins in Past Ten at Home

Buffalo have six wins and four losses in the last 10 games at home, putting up 31.20 points on average and giving up 20.50.

UConn own a 4-6 mark in their past 10 games away from home, putting up 25.50 points per contest and giving up 31.90.

Last 10 Games		W-L	P	PF	PA	O50.5	U50.5
Buffalo Home Stats		6-4	51.70	31.20	20.50	3	7
UConn Away Stats		4-6	57.40	25.50	31.90	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O50.5 = Games Over 50.5 Points
• U50.5 = Games Under 50.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

UConn Stats

Buffalo Bulls Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• -3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -3.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• +3.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +3.5 Betting Line at Home: Have covered the spread in 6 of the last 10 home games

Total Points

• Game Totals: An average of 58.70 pts in the previous 10 games
• Game Totals on the Road: An average of 57.40 pts in the previous 10 games on the road
• Over 50.5: Covered in 7 of the previous 10 games
• Over 50.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 33.10 pts and allowed 25.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 25.50 pts and allowed 31.90 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.40 pts in the previous 10 games
• Game Totals at Home: An average of 51.70 pts in the previous 10 home games
• Over 50.5: Covered in 6 of the previous 10 games
• Over 50.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 31.70 pts and allowed 23.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 31.20 pts and allowed 20.50 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Mid-American	W	L	PF	PA	N. Pts	Home	Away	Strk
Bowling Green	2	2	86	94	-8	2-0	0-2	1L
Buffalo	2	2	103	78	25	1-1	1-1	1L
Central Michigan	2	2	85	132	-47	1-0	1-2	1W
Ohio	2	2	109	116	-7	2-0	0-2	1W
Toledo	2	2	134	59	75	2-0	0-2	1L
Northern Illinois	1	2	38	75	-37	1-0	0-2	2L
Akron	1	3	79	116	-37	1-1	0-2	1W
Ball State	1	3	62	133	-71	1-0	0-3	1L
Eastern Michigan	1	3	107	159	-52	1-1	0-2	1W
Kent State	1	3	73	176	-103	1-1	0-2	3L
Western Michigan	1	3	50	107	-57	1-1	0-2	1W
Massachusetts	0	3	43	116	-73	0-2	0-1	3L
Miami (OH)	0	3	55	103	-48	0-1	0-2	3L

Independents I-A	W	L	PF	PA	N. Pts	Home	Away	Strk
UConn	2	2	151	109	42	2-0	0-2	1W
Notre Dame	1	2	120	98	22	1-1	0-1	1W