USC vs Oregon Prediction, Picks & Odds | 22 Nov 2025

College Football Betting Preview: USC vs Oregon

USC square off against Oregon at Autzen Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.

There’s every chance that the total won’t be as high as 59.5, so we’re prepared to take the -115 that Oregon and USC go under the line.

Expecting the clock to be the MVP? Get the best BetMGM promo code and see what our review says before locking in your wager.

USC Trojans claimed a home victory in their previous game. A 26-21 triumph against Iowa Hawkeyes at LA Memorial Coliseum made it three straight wins.

Oregon Ducks last game was a 42-13 home win. This victory over Minnesota Golden Gophers at Autzen Stadium was their fourth successive victory.

Head-to-Head Statistics

The scoreline was 36-27 in favor of Oregon when they last played USC, with the matchup taking place at Autzen Stadium. Oregon have won on the past 3 times these teams have gone H2H.

Quarterbacks

Jayden Maiava

243.5 Passing Yards

Over -114

Under -114

Dante Moore

228.5 Passing Yards

Over -114

Under -114

USC vs Oregon Prediction & Picks

Our USC vs Oregon tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.

Game Prediction

Under 59.5 points looks like an attractive total wager. The teams might not be able to reach this combined amount and we can profit with this college football pick at -115.

We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.

Key USC vs Oregon stats:

• The 59.5 line hasn’t been covered in the last 5 USC games.
• The 59.5 line hasn’t been covered in 9 of the last 10 USC games on the road.
• The 59.5 line hasn’t been covered in 12 of the last 20 USC games.
• The 59.5 line hasn’t been covered in the last 4 Oregon games at home this season.
• The 59.5 line hasn’t been covered in 7 of the last 10 Oregon games.
• The 59.5 line hasn’t been covered in 13 of the last 20 Oregon games.

Under 59.5 Probability

The top sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. However, we have this figure at close to 60% based on our in-depth research. That means we’re regarding it as a value bet.

The sportsbooks will allow you to shoot for bigger odds on your Under bet. By moving the line and going for a lower Total, there’s the chance to get more juice.

Don’t start wagering without checking our guide to the newest betting promo codes, best welcome bonuses and free bet offers.

Our Game Prediction

Under 59.5 Points @ -115 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Player Prop Picks

Top Pick: Dante Moore Under 228.5 Passing Yards -114

Dante Moore (Oregon) is available at -114 to finish with fewer than 228.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.

Latest Dante Moore Player Prop Odds

Passing Yards

Over 228.5

-114

Under 228.5

-114

---

Ja'Kobi Lane Under 54.5 Receiving Yards -114

Ja'Kobi Lane (Oregon) is priced at -114 to finish with fewer than 54.5 receiving yards. We’re confident he’ll fall short of the Player Receiving Yards line, as the total looks too high.

Latest Ja'Kobi Lane Player Prop Odds

Receiving Yards

Over 54.5

-114

Under 54.5

-114

Correct Score Prediction

USC 20 - 35 Oregon

For those looking to get more bang for their buck, consider a correct score wager on the Ducks. Backing them to win 35-20 means you can land a potential monster return.

USC vs Oregon Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Oregon have the shortest price to win this college game, with the sportsbooks giving them a 79% probability due to their -385 Moneyline betting odds. USC are regarded as a long shot to win and you can currently back them at +310.

The spread is 9.5 and the total points line is currently 59.5. There is no denying the popularity of wagering on the Totals. If you want to bet Under 59.5, there are odds of -115.

When it comes to college football, the top betting apps deliver a wide variety of game lines and team props. With so many options available, it’s worth taking your time to find the wager that fits your view of the matchup.

Moneyline

USC

+310

Oregon

-385

Point Spread

USC +9.5

-102

Oregon -9.5

-120

Total Points

Under 59.5

-115

Over 59.5

-105

Receiving Yards

Makai Lemon (USC)

Over 99.5

-114

Under 99.5

-114

Ja'Kobi Lane (USC)

Over 54.5

-114

Under 54.5

-114

Kenyon Sadiq (Oregon)

Over 49.5

-114

Under 49.5

-114

Jeremiah McClellan (Oregon)

Over 36.5

-114

Under 36.5

-114

Malik Benson (Oregon)

Over 34.5

-114

Under 34.5

-114

Lake McRee (USC)

Over 25.5

-114

Under 25.5

-114

Rushing Yards

Noah Whittington (Oregon)

Over 83.5

-114

Under 83.5

-114

King Miller (USC)

Over 72.5

-114

Under 72.5

-114

Jordon Davison (Oregon)

Over 53.5

-114

Under 53.5

-114

Passing Yards

Jayden Maiava (USC)

Over 243.5

-114

Under 243.5

-114

Dante Moore (Oregon)

Over 228.5

-114

Under 228.5

-114

Oregon Hold Nine Wins in Previous Ten at Home

Oregon are 9-1 in their last 10 home games, putting up 41.00 points per contest and giving up 15.20.

USC have a 4-6 record in their last 10 games away from home, putting up 24.60 points on average and giving up 24.10.

Oregon defeated USC 36-27 in their last meeting at Autzen Stadium.

Last 10 Games		W-L	P	PF	PA	O59.5	U59.5
Oregon Home Stats		9-1	56.20	41.00	15.20	4	6
USC Away Stats		4-6	48.70	24.60	24.10	1	9

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O59.5 = Games Over 59.5 Points
• U59.5 = Games Under 59.5 Points

Latest regular season and playoff games stats.

USC Stats

Oregon Ducks Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 59.90 pts in the previous 10 games
• Game Totals on the Road: An average of 48.70 pts in the previous 10 games on the road
• Over 59.5: Covered in 4 of the previous 10 games
• Over 59.5 on the Road: Covered in 1 of the previous 10 games on the road
• Team Totals: Have scored an average of 38.20 pts and allowed 21.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 24.60 pts and allowed 24.10 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 52.70 pts in the previous 10 games
• Game Totals at Home: An average of 59.60 pts in the previous 10 home games
• Over 59.5: Covered in 3 of the previous 10 games
• Over 59.5 at Home: Covered in 5 of the previous 10 home games
• Team Totals: Have scored an average of 39.00 pts and allowed 13.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 40.60 pts and allowed 19.00 pts in the last 10 home games

Top American Football Pages