USC vs Oregon Prediction, Picks & Odds | 22 Nov 2025
College Football Betting Preview: USC vs Oregon
USC square off against Oregon at Autzen Stadium, with kickoff scheduled for 15:30 on Saturday, November 22.
There’s every chance that the total won’t be as high as 59.5, so we’re prepared to take the -115 that Oregon and USC go under the line.
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USC Trojans claimed a home victory in their previous game. A 26-21 triumph against Iowa Hawkeyes at LA Memorial Coliseum made it three straight wins.
Oregon Ducks last game was a 42-13 home win. This victory over Minnesota Golden Gophers at Autzen Stadium was their fourth successive victory.
Head-to-Head Statistics
The scoreline was 36-27 in favor of Oregon when they last played USC, with the matchup taking place at Autzen Stadium. Oregon have won on the past 3 times these teams have gone H2H.
Quarterbacks
Jayden Maiava
Dante Moore
USC vs Oregon Prediction & Picks
Our USC vs Oregon tips include the main match prediction, a correct score forecast, bet builder advice and top player prop picks. Each section below offers expert insight into the key betting angles.
Game Prediction
Under 59.5 points looks like an attractive total wager. The teams might not be able to reach this combined amount and we can profit with this college football pick at -115.
We put solid research behind every CFB pick, starting with recent form and a clear read on injuries. From there, key stats and advanced metrics help complete the picture and support smarter betting decisions.
Key USC vs Oregon stats:
Under 59.5 Probability
The top sportsbooks are estimating that there is a 53.5% likelihood of this pick winning. However, we have this figure at close to 60% based on our in-depth research. That means we’re regarding it as a value bet.
The sportsbooks will allow you to shoot for bigger odds on your Under bet. By moving the line and going for a lower Total, there’s the chance to get more juice.
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Player Prop Picks
Dante Moore (Oregon) is available at -114 to finish with fewer than 228.5 passing yards. We’re confident he’ll fall short of the QB Passing Yards line, as the total looks too high.
Ja'Kobi Lane (Oregon) is priced at -114 to finish with fewer than 54.5 receiving yards. We’re confident he’ll fall short of the Player Receiving Yards line, as the total looks too high.
Same Game Parlay Picks
Take a same game parlay that incorporates Under 59.5 points followed by Oregon to cover the -9.5 spread. We’ve also gone for Dante Moore (Oregon) to have Under 228.5 passing yards.
A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
20
-
35
Oregon
For those looking to get more bang for their buck, consider a correct score wager on the Ducks. Backing them to win 35-20 means you can land a potential monster return.
USC vs Oregon Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
Oregon have the shortest price to win this college game, with the sportsbooks giving them a 81% probability due to their -435 Moneyline betting odds. USC are regarded as a long shot to win and you can currently back them at +340.
The spread is 12.5 and the total points line is currently 55.5. There is no denying the popularity of wagering on the Totals. If you want to bet Under 55.5, there are odds of -110.
When it comes to college football, the top betting apps deliver a wide variety of game lines and team props. With so many options available, it’s worth taking your time to find the wager that fits your view of the matchup.
Favorite Jordon Davison is priced at +550 to be the first player to score a touchdown. There’s also the chance to back him to score a TD at anytime at odds of -164.
Touchdown
Receiving Yards
Rushing Yards
Passing Yards
An increasing number of bettors are now enjoying micro betting on college football and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.
Oregon Hold Nine Wins in Previous Ten at Home
Oregon are 9-1 in their last 10 home games, putting up 41.00 points per contest and giving up 15.20.
USC have a 4-6 record in their last 10 games away from home, putting up 24.60 points on average and giving up 24.10.
Oregon defeated USC 36-27 in their last meeting at Autzen Stadium.
| Last 10 Games | W-L | P | PF | PA | O59.5 | U59.5 | |
|---|---|---|---|---|---|---|---|
 Oregon Home Stats |
9-1 | 56.20 | 41.00 | 15.20 | 4 | 6 | |
 USC Away Stats |
4-6 | 48.70 | 24.60 | 24.10 | 1 | 9 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O59.5 = Games Over 59.5 Points
- U59.5 = Games Under 59.5 Points
Latest regular season and playoff games stats.
USC Stats
Oregon Ducks Stats
- 8 wins and 2 defeats in the last 10 games
- 4 wins and 6 defeats in the last 10 games on the road
- +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +9.5 Betting Line on the Road: Have covered the spread in 9 of the last 10 games on the road
- -9.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -9.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 59.90 pts in the previous 10 games
- Game Totals on the Road: An average of 48.70 pts in the previous 10 games on the road
- Over 59.5: Covered in 4 of the previous 10 games
- Over 59.5 on the Road: Covered in 1 of the previous 10 games on the road
- Team Totals: Have scored an average of 38.20 pts and allowed 21.70 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 24.60 pts and allowed 24.10 pts in the last 10 games on the road
- Game Totals: An average of 52.70 pts in the previous 10 games
- Game Totals at Home: An average of 59.60 pts in the previous 10 home games
- Over 59.5: Covered in 3 of the previous 10 games
- Over 59.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 39.00 pts and allowed 13.70 pts in the last 10 games
- Team Totals at Home: Have scored an average of 40.60 pts and allowed 19.00 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
13 | 0 | 545 | 141 | 404 | 7-0 | 6-0 | 13W |
Ohio State
|
12 | 1 | 454 | 106 | 348 | 7-1 | 5-0 | 1L |
|
Oregon
|
11 | 1 | 458 | 178 | 280 | 6-1 | 5-0 | 6W |
Michigan
|
9 | 3 | 331 | 224 | 107 | 5-1 | 4-2 | 1L |
|
USC
|
9 | 3 | 438 | 269 | 169 | 7-0 | 2-3 | 1W |
Iowa
|
8 | 4 | 347 | 182 | 165 | 5-2 | 3-2 | 2W |
Illinois
|
8 | 4 | 352 | 279 | 73 | 6-1 | 2-3 | 1W |
Washington
|
8 | 4 | 405 | 233 | 172 | 5-2 | 3-2 | 1L |
Minnesota
|
7 | 5 | 279 | 281 | -2 | 7-0 | 0-5 | 1W |
Nebraska
|
7 | 5 | 351 | 276 | 75 | 4-3 | 3-2 | 2L |
Northwestern
|
6 | 6 | 270 | 251 | 19 | 5-2 | 1-4 | 1L |
Penn State
|
6 | 6 | 381 | 257 | 124 | 4-3 | 2-3 | 3W |
Rutgers
|
5 | 7 | 344 | 382 | -38 | 4-3 | 1-4 | 2L |
Wisconsin
|
4 | 8 | 154 | 259 | -105 | 4-3 | 0-5 | 1L |
Maryland
|
4 | 8 | 282 | 318 | -36 | 3-4 | 1-4 | 8L |
Michigan State
|
4 | 8 | 295 | 359 | -64 | 4-3 | 0-5 | 1W |
UCLA
|
3 | 9 | 218 | 401 | -183 | 2-4 | 1-5 | 5L |
Purdue
|
2 | 10 | 225 | 382 | -157 | 2-5 | 0-5 | 10L |
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