USC vs Purdue Prediction, Picks & Odds | 13 Sep 2025

College Football Betting Preview: USC vs Purdue

USC face off against Purdue in this NCAAF matchup at Ross-Ade Stadium, with kickoff scheduled for 15:30 on Saturday 13 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

We’re Expecting a Low Points Total

We’re not convinced Purdue and USC are cumulatively going to produce enough points in relation to the total line. Therefore, we’re aiming to go Under 58.5 at -110.

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Both Teams Victorious in Last Game

USC Trojans claimed a home victory in their previous game. A 59-20 triumph against Georgia Southern Eagles at LA Memorial Coliseum made it back-to-back wins.

Purdue Boilermakers made it back-to-back wins in their last game. Landing a 34-17 home victory against Southern Illinois at Ross-Ade Stadium.

Quarterbacks

Jayden Maiava

262.5 Passing Yards

Over -114

Under -114

Ryan Browne

197.5 Passing Yards

Over -114

Under -114

USC vs Purdue Prediction & Picks

Make the most of USC vs Purdue with our betting analysis that includes an expert match prediction, expected scoreline, key player prop picks and a value-focused bet builder.

Game Prediction

When the teams line up in this college football matchup, we’re not sure that the total points will go over the line. Based on this pick, you can land odds of -110 for Under 58.5 and this looks worth taking.

The CFB handicappers at Sportsgambler.com always keep close tabs on team news as it develops. We also rely on recent form and key stats to help shape our picks and guide the final call.

Key USC vs Purdue stats:

• The 58.5 line hasn’t been covered in the last 6 USC games on the road.
• The 58.5 line hasn’t been covered in 11 of the last 20 USC games on the road.
• The 58.5 line hasn’t been covered in 4 of the last 5 Purdue games at home.
• The 58.5 line hasn’t been covered in 7 of the last 10 Purdue games.
• The 58.5 line hasn’t been covered in the last 2 Purdue games.

Under 58.5 Probability

According to the top sportsbooks, our pick has a 52.4% chance of delivering a return. In the opinion of our analysts, there’s actually a probability of success closer to 60%. This is why we regard this as a value bet.

Bigger odds are always a good thing and bettors can regularly move the line when it comes to wagering Under on the Totals. Choose the option which suits you best.

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Best Bet

Under 58.5 Points @ -110 Bet Now

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Player Prop Picks

Top Pick: Jayden Maiava Under 262.5 Passing Yards -114

Jayden Maiava (USC) is priced at -114 to finish with fewer than 262.5 passing yards. He could struggle to reach the QB Passing Yards line, making this prop bet highly appealing.

Latest Jayden Maiava Player Prop Odds

Passing Yards

Over 262.5

-114

Under 262.5

-114

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Devin Mockobee Under 63.5 Rushing Yards -114

Devin Mockobee (Purdue) can be backed at -114 to have less than 63.5 rushing yards. He is likely to fall short of the line, making this Player Rushing Yards bet an appealing option.

Latest Devin Mockobee Player Prop Odds

Rushing Yards

Over 63.5

-114

Under 63.5

-114

Correct Score Prediction

USC 41 - 10 Purdue

Should you want to go for a selection at massive odds, head to the correct score lines where the Trojans can be backed speculatively to achieve a 41-10 victory.

USC vs Purdue Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

USC Heavy Favorites to Win

USC are massive -1667 favorites. They are regarded as 94% likely to win this college game judging by the sportsbooks’ latest Moneyline odds. For those wanting to oppose the market leader, you can get +920 about Purdue.

The current spread is 21.5 and the total points line is 59.5. The beauty of the Totals is that you only have to choose from one of two options. Those that want to back Under 59.5 can find odds of -115 available.

When it comes to college football, the top betting apps deliver a wide variety of game lines and team props. With so many options available, it’s worth taking your time to find the wager that fits your view of the matchup.

Moneyline

USC

-1667

Purdue

+920

Point Spread

USC -21.5

-102

Purdue +21.5

-120

Total Points

Under 59.5

-115

Over 59.5

-105

Player Odds

Receiving Yards

Makai Lemon (USC)

Over 85.5

-114

Under 85.5

-114

Michael Jackson III (Purdue)

Over 31.5

-114

Under 31.5

-114

Lake McRee (USC)

Over 29.5

-114

Under 29.5

-114

Arhmad Branch (Purdue)

Over 28.5

-114

Under 28.5

-114

Rushing Yards

Waymond Jordan (USC)

Over 80.5

-114

Under 80.5

-114

Devin Mockobee (Purdue)

Over 63.5

-114

Under 63.5

-114

Passing Yards

Jayden Maiava (USC)

Over 262.5

-114

Under 262.5

-114

Ryan Browne (Purdue)

Over 197.5

-114

Under 197.5

-114

Purdue Standing on Five Wins From Last Ten Home Matches

Purdue own a 5-5 mark in their past 10 home games, scoring 24.50 points per contest and conceding 28.20.

USC have a 4-6 record in their last 10 games away from home, posting 28.10 points per contest while yielding 31.30.

Last 10 Games		W-L	P	PF	PA	O58.5	U58.5
Purdue Home Stats		5-5	52.70	24.50	28.20	4	6
USC Away Stats		4-6	59.40	28.10	31.30	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O58.5 = Games Over 58.5 Points
• U58.5 = Games Under 58.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

USC Stats

Purdue Boilermakers Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• -21.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -21.5 Betting Line on the Road: Have not covered the spread in any of the last 10 games on the road

Point Spread

• +21.5 Betting Line: Have covered the spread in 5 of the last 10 games
• +21.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 62.40 pts in the previous 10 games
• Game Totals on the Road: An average of 59.40 pts in the previous 10 games on the road
• Over 58.5: Covered in 6 of the previous 10 games
• Over 58.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 37.00 pts and allowed 25.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 28.10 pts and allowed 31.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.10 pts in the previous 10 games
• Game Totals at Home: An average of 52.70 pts in the previous 10 home games
• Over 58.5: Covered in 3 of the previous 10 games
• Over 58.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 16.70 pts and allowed 36.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.50 pts and allowed 28.20 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	W	L	PF	PA	N. Pts	Home	Away	Strk
Illinois	2	0	97	22	75	1-0	1-0	2W
Penn State	2	0	80	11	69	2-0	0-0	2W
Wisconsin	2	0	59	10	49	2-0	0-0	2W
Washington	2	0	108	31	77	2-0	0-0	2W
USC	2	0	132	33	99	2-0	0-0	2W
Rutgers	2	0	79	48	31	2-0	0-0	2W
Indiana	2	0	83	23	60	2-0	0-0	2W
Purdue	2	0	65	17	48	2-0	0-0	2W
Oregon	2	0	128	16	112	2-0	0-0	2W
Ohio State	2	0	84	7	77	2-0	0-0	2W
Nebraska	2	0	88	17	71	1-0	1-0	2W
Minnesota	2	0	89	10	79	2-0	0-0	2W
Michigan State	2	0	65	46	19	2-0	0-0	2W
Maryland	2	0	59	16	43	2-0	0-0	2W
Iowa	1	1	47	23	24	1-0	0-1	1L
Michigan	1	1	47	41	6	1-0	0-1	1L
Northwestern	1	1	45	30	15	1-0	0-1	1W
UCLA	0	2	33	73	-40	0-1	0-1	2L