Virginia vs Duke Prediction, Picks & Odds | 15 Nov 2025
College Football Betting Preview: Virginia vs Duke
Virginia square off against Duke at Wallace Wade Stadium, with kickoff scheduled for 15:30 on Saturday, November 15.
Virginia look easy to back at -110 considering the underdogs have been given a spread of +4.5. This looks a good number when squaring off against Duke.
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Virginia Cavaliers have won their previous three road outings. In their most recent game, they were turned over 16-9 at home to Wake Forest at Scott Stadium.
Duke Blue Devils were defeated in their last game. On the road, they suffered a 37-34 reverse against UConn Huskies at Rentschler Field.
Head-to-Head Statistics
Virginia had the edge in the most recent matchup between these teams. At Scott Stadium, they recorded a 30-27 win over Duke. Virginia have triumphed in four of the previous 5 clashes between these teams.
Virginia vs Duke Prediction & Picks
Prepare for Virginia vs Duke with our expert betting guide featuring a trusted match prediction, likely scoreline, key player props and a well-crafted bet builder.
Game Prediction
With Virginia capable of remaining close to the favorites, backing them against the spread could be the best way forward. -110 is available that the +4.5 is covered in this college football matchup.
Team news and current form always play a key role in shaping our expert CFB predictions. We also dig into the latest stats and trends to help deliver the most accurate picks possible.
Key Virginia vs Duke stats:
UVA +4.5 Probability
Looking at the latest betting odds, our pick has a 52.4% chance of winning. In the opinion of our analysts, there’s actually a probability of success between 55-60%. This is why we can recommend this college wager.
There’s the opportunity to sell points and that means moving the line until you’re happy with the bet. It means a riskier wager but a bigger return on the odds available.
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Player Prop Picks
Darian Mensah (Duke) can be backed at -114 to finish with fewer than 281.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.
Cam Ross (Duke) is available at -114 to finish with fewer than 43.5 receiving yards. It’s reasonable to expect he may fall short, making the Player Receiving Yards line appealing.
Same Game Parlay Picks
Try out our same game parlay pick which starts with Virginia +4.5. We’ve also gone for Under 58.5 points and Darian Mensah (Duke) to have Under 281.5 passing yards.
A same game parlay is a fantastic option for bettors who want to focus their wagering on a single football game. You can predict different outcomes and see their odds combined before going ahead and placing this tailored bet.
Correct Score Prediction
28
-
27
Duke
There might not be too much between these teams, with our correct score pick being a 28-27 victory for the Cavs. There are huge odds available when it comes to this prediction.
Virginia vs Duke Odds
The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.
The Duke odds have been priced up by the sportsbooks and they are -196 betting favorites to land victory in this college game which means a 66% chance of winning. The market suggests that Virginia are least likely to win at +166.
The spread is 4.5 and the total points line is currently 60.5. Football fans love the chance to get an alternative angle by going for a Total wager. Those that want to back Under 60.5 can find odds of -110 available.
Whether you are betting pre-game or in-game on college football, the best sportsbooks let you feast on a wide range of game lines and team props. The selections are practically endless, and it’s fantastic to have so many options.
J'Mari Taylor is favorite to be First Touchdown Scorer at +440. If you want to back him to score the last TD, you can get similar odds.
Touchdown
Receiving Yards
Rushing Yards
Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.
Duke Have Won Seven of Their Last Ten Home Games
Duke own a 7-3 mark in their past 10 home games, scoring 28.10 points per contest and conceding 23.80.
Virginia have reeled off three straight road wins. They have gone 6-4 across their last 10 games away from home, averaging 26.90 points scored and 29.20 points allowed.
In their last matchup at Wallace Wade Stadium, Duke came out on top 38-17 against Virginia.
| Last 10 Games | W-L | P | PF | PA | O58.5 | U58.5 | |
|---|---|---|---|---|---|---|---|
 Duke Home Stats |
7-3 | 51.90 | 28.10 | 23.80 | 4 | 6 | |
 Virginia Away Stats |
6-4 | 56.10 | 26.90 | 29.20 | 4 | 6 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O58.5 = Games Over 58.5 Points
- U58.5 = Games Under 58.5 Points
Latest regular season and playoff games stats.
Virginia Cavaliers Stats
Duke Blue Devils Stats
- 8 wins and 2 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +4.5 Betting Line: Have covered the spread in 9 of the last 10 games
- +4.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -4.5 Betting Line: Have covered the spread in 4 of the last 10 games
- -4.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games
- Game Totals: An average of 55.30 pts in the previous 10 games
- Game Totals on the Road: An average of 56.10 pts in the previous 10 games on the road
- Over 58.5: Covered in 4 of the previous 10 games
- Over 58.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 33.70 pts and allowed 21.60 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 26.90 pts and allowed 29.20 pts in the last 10 games on the road
- Game Totals: An average of 65.10 pts in the previous 10 games
- Game Totals at Home: An average of 51.90 pts in the previous 10 home games
- Over 58.5: Covered in 8 of the previous 10 games
- Over 58.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 33.70 pts and allowed 31.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 28.10 pts and allowed 23.80 pts in the last 10 home games
| Atlantic Coast | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
|
Virginia
|
10 | 2 | 398 | 240 | 158 | 6-1 | 4-1 | 2W |
Miami
|
10 | 2 | 409 | 166 | 243 | 7-1 | 3-1 | 4W |
Georgia Tech
|
9 | 3 | 397 | 300 | 97 | 5-2 | 4-1 | 2L |
Pittsburgh
|
8 | 4 | 421 | 299 | 122 | 4-3 | 4-1 | 1L |
SMU
|
8 | 4 | 395 | 248 | 147 | 5-1 | 3-3 | 1L |
Louisville
|
8 | 4 | 362 | 253 | 109 | 5-3 | 3-1 | 1W |
Wake Forest
|
8 | 4 | 322 | 258 | 64 | 5-2 | 3-2 | 1L |
|
Duke
|
7 | 5 | 415 | 353 | 62 | 3-3 | 4-2 | 2W |
NC State
|
7 | 5 | 362 | 346 | 16 | 6-1 | 1-4 | 2W |
Clemson
|
7 | 5 | 344 | 245 | 99 | 3-4 | 4-1 | 4W |
California
|
7 | 5 | 298 | 318 | -20 | 4-2 | 3-3 | 1W |
Florida State
|
5 | 7 | 396 | 264 | 132 | 5-2 | 0-5 | 2L |
Stanford
|
4 | 8 | 226 | 350 | -124 | 4-2 | 0-6 | 1L |
North Carolina
|
4 | 8 | 231 | 294 | -63 | 2-4 | 2-4 | 3L |
Virginia Tech
|
3 | 9 | 257 | 362 | -105 | 2-5 | 1-4 | 4L |
Syracuse
|
3 | 9 | 242 | 419 | -177 | 2-4 | 1-5 | 8L |
Boston College
|
2 | 10 | 305 | 393 | -88 | 1-6 | 1-4 | 1W |
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