Falcons vs Cardinals Prediction, Picks & Odds | 21 Dec 2025

NFL Betting Preview: Falcons vs Cardinals

The Atlanta Falcons face the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, December 21.

Let’s go for Over 48.5 when the Cardinals face the Falcons. We think the line is too generous and we’re expecting the final total to be higher at -105.

If you’re liking our Totals pick, grab the latest BetMGM promo code and check out the comprehensive site review to make the most of your wager.

Atlanta Falcons triumphed in their previous game. It was on the road where Tampa Bay Buccaneers were beaten 29-28 at Raymond James Stadium. The Falcons recorded 476 yards, breaking down to 365 passing and 111 rushing yards. The offense converted for 27 first downs and reached the end zone 4 times, 3 by pass and one by run.

Arizona Cardinals lost on the road in their last game, making it six straight defeats. Houston Texans won 40-20 at NRG Stadium. The Cardinals totaled 307 yards, with 235 through the air and 72 on the ground. The offense picked up 22 first downs and crossed the goal line 3 times.

Head-to-Head Statistics

The Cardinals beat the Falcons when the teams last met. It was a 25-23 scoreline at State Farm Stadium. The previous 3 H2H meetings have involved the Cardinals winning two times.

Quarterbacks

Kirk Cousins

227.5 Passing Yards

Over -114

Under -114

Jacoby Brissett

254.5 Passing Yards

Over -114

Under -114

Falcons vs Cardinals Prediction & Picks

Get fully prepped for Falcons vs Cardinals with our betting guide, featuring our expert match pick, predicted scoreline, top player props and a value-focused bet builder.

Game Prediction

The best betting angle could be wagering on the totals for this NFL matchup. Our pick is for Over 48.5 points to be scored at odds of -105 which makes lots of appeal.

Our NFL handicappers study recent form and take injuries into account when assessing each matchup. Before delivering a verdict, we combine that insight with the latest stats to strengthen our analysis.

Key Falcons vs Cardinals stats:

• The 48.5 line has been covered in 3 of the last 5 Falcons games.
• The 48.5 line has been covered in the last 2 Falcons games on the road.
• The 48.5 line has been covered in the last 4 Cardinals games at home this season.
• The 48.5 line has been covered in 5 of the last 7 Cardinals games at home this season.
• The 48.5 line has been covered in 7 of the last 10 Cardinals games.

Over 48.5 Probability

If you go by the best betting sites, our pick has a 51.3% chance of winning. Our analysts think there’s a stronger chance of success and calculate the probability to be 55-60%. The bet can be recommended for this precise reason.

Looking for a bigger return on your Total bet? Consider the Result & Total lines where you combine the winning franchise and Over a certain number of points.

Check out our latest betting offers guide — packed with top free bet deals and exclusive welcome bonuses.

Our Game Prediction

Over 48.5 Points @ -105 Bet Now

BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+

Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Player Prop Picks

Top Pick: Jacoby Brissett Over 254.5 Passing Yards -114

You can place a bet on Jacoby Brissett (Cardinals) at -114 to surpass 254.5 passing yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.

Latest Jacoby Brissett Player Prop Odds

Touchdown

Anytime

+500

First

+3000

Passing Yards

Over 254.5

-114

Under 254.5

-114

---

Tyler Allgeier Over 29.5 Rushing Yards -114

The odds for Tyler Allgeier (Falcons) to exceed 29.5 rushing yards stand at -114. We can place a Player Rushing Yards bet with confidence, as we expect him to cover the line.

Latest Tyler Allgeier Player Prop Odds

Touchdown

Anytime

+145

First

+850

Rushing Yards

Over 29.5

-114

Under 29.5

-114

Correct Score Prediction

Falcons 31 - 24 Cardinals

For those looking to get more bang for their buck, consider a correct score bet on the Falcons. Backing them to win 31-24 means you can land a potential monster return.

Falcons vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Atlanta Falcons are regarded as having a 61% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at -156. At +132, Arizona Cardinals are regarded as having a lower probability of winning.

The current spread is 2.5 and total points is 48.5. A Total bet is always available and can often provide value selections. If you’re going for Over 48.5, then the odds are -105.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Falcons

-156

Cardinals

+132

Point Spread

Falcons -2.5

-120

Cardinals +2.5

-102

Total Points

Under 48.5

-115

Over 48.5

-105

Bijan Robinson can be backed to score a touchdown at anytime at -222. He is the favorite to score the first TD at odds of +320.

Touchdown

Bijan Robinson (Falcons)

First TD

+320

Anytime TD

-222

Drake London (Falcons)

First TD

+700

Anytime TD

+135

Michael Carter (Cardinals)

First TD

+750

Anytime TD

+110

Trey McBride (Cardinals)

First TD

+800

Anytime TD

+115

Tyler Allgeier (Falcons)

First TD

+850

Anytime TD

+145

Kyle Pitts (Falcons)

First TD

+900

Anytime TD

+185

Michael Wilson (Cardinals)

First TD

+1000

Anytime TD

+160

Marvin Harrison Jr. (Cardinals)

First TD

+1300

Anytime TD

+230

Emari Demercado (Cardinals)

First TD

+3000

Anytime TD

+390

Jacoby Brissett (Cardinals)

First TD

+3000

Anytime TD

+500

Darnell Mooney (Falcons)

First TD

+3000

Anytime TD

+420

Xavier Weaver (Cardinals)

First TD

+4500

Anytime TD

+550

Jalen Brooks (Cardinals)

First TD

+4500

Anytime TD

+550

David Sills V (Falcons)

First TD

+5000

Anytime TD

+800

Elijah Higgins (Cardinals)

First TD

+5000

Anytime TD

+600

Corey Kiner (Cardinals)

First TD

+6500

Anytime TD

+1000

KhaDarel Hodge (Falcons)

First TD

+7000

Anytime TD

+1700

Kirk Cousins (Falcons)

First TD

+7000

Anytime TD

+1300

Charlie Woerner (Falcons)

First TD

+7500

Anytime TD

+1100

Dylan Drummond (Falcons)

First TD

+8000

Anytime TD

+1500

Jamal Agnew (Falcons)

First TD

+8000

Anytime TD

+1700

Casey Washington (Falcons)

First TD

+8000

Anytime TD

+1700

Deven Thompkins (Falcons)

First TD

+8000

Anytime TD

+1700

Josiah Deguara (Cardinals)

First TD

+8000

Anytime TD

+1000

Pharaoh Brown (Cardinals)

First TD

+8000

Anytime TD

+1000

Malik Heath (Falcons)

First TD

+8000

Anytime TD

+1400

Teagan Quitoriano (Falcons)

First TD

+10000

Anytime TD

+2200

Feleipe Franks (Falcons)

First TD

+10000

Anytime TD

+2200

Nathan Carter (Falcons)

First TD

+10000

Anytime TD

+5000

Receiving Yards

Drake London (Falcons)

Over 75.5

-114

Under 75.5

-114

Trey McBride (Cardinals)

Over 71.5

-114

Under 71.5

-114

Michael Wilson (Cardinals)

Over 58.5

-114

Under 58.5

-114

Kyle Pitts (Falcons)

Over 52.5

-114

Under 52.5

-114

Marvin Harrison Jr. (Cardinals)

Over 51.5

-114

Under 51.5

-114

Bijan Robinson (Falcons)

Over 37.5

-114

Under 37.5

-114

Rushing Yards

Bijan Robinson (Falcons)

Over 88.5

-114

Under 88.5

-114

Michael Carter (Cardinals)

Over 53.5

-114

Under 53.5

-114

Tyler Allgeier (Falcons)

Over 29.5

-114

Under 29.5

-114

Passing Yards

Jacoby Brissett (Cardinals)

Over 254.5

-114

Under 254.5

-114

Kirk Cousins (Falcons)

Over 227.5

-114

Under 227.5

-114

Cardinals Run Includes Six Consecutive Home Losses

The Cardinals are riding a skid of six straight defeats at State Farm Stadium. They have gone 3-7 across their last 10 home games, averaging 24.90 points on offense and surrendering 27.80 on defense.

The Falcons have a 4-6 record in their last 10 games away from home, putting up 19.60 points on average and giving up 21.50.

The last time the Cardinals faced the Falcons at State Farm Stadium, they won 25-23.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Cardinals Home Stats		3-7	52.70	24.90	27.80	6	4
Falcons Away Stats		4-6	41.10	19.60	21.50	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Latest regular season and playoff games stats.

Atlanta Falcons Stats

Arizona Cardinals Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 46.00 pts in the previous 10 games
• Game Totals on the Road: An average of 41.10 pts in the previous 10 games on the road
• Over 48.5: Covered in 4 of the previous 10 games
• Over 48.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.50 pts and allowed 25.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.60 pts and allowed 21.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.40 pts in the previous 10 games
• Game Totals at Home: An average of 52.70 pts in the previous 10 home games
• Over 48.5: Covered in 7 of the previous 10 games
• Over 48.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 22.00 pts and allowed 31.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.90 pts and allowed 27.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 331.50 Yds. Allowed 355.40 Yds
• Rushing Yards: Gained 117.20 Yds. Allowed 135.50 Yds
• Passing Yards: Gained 214.30 Yds. Allowed 219.90 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 19.40. Allowed 21.90
• Total Turnovers: Committed 1.00. Committed by opponents 1.10
• Total Penalties: Committed 7.10. Committed by opponents 5.50
• Penalty Yards: Lost 56.30 Yds. Gained 44.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 358.60 Yds. Allowed 350.90 Yds
• Rushing Yards: Gained 90.70 Yds. Allowed 135.90 Yds
• Passing Yards: Gained 267.90 Yds. Allowed 215.00 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 3.60 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 21.80. Allowed 21.60
• Total Turnovers: Committed 1.50. Committed by opponents 1.30
• Total Penalties: Committed 6.50. Committed by opponents 5.30
• Penalty Yards: Lost 50.60 Yds. Gained 42.90 Yds

Last 10 Games on the Road

• Total Yards: Gained 329.30 Yds. Allowed 315.70 Yds
• Rushing Yards: Gained 131.50 Yds. Allowed 135.30 Yds
• Passing Yards: Gained 197.80 Yds. Allowed 180.40 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 19.60. Allowed 20.60
• Total Turnovers: Committed 1.10. Committed by opponents 1.70
• Total Penalties: Committed 6.10. Committed by opponents 6.30
• Penalty Yards: Lost 45.90 Yds. Gained 48.40 Yds

Last 10 Home Games

• Total Yards: Gained 350.80 Yds. Allowed 366.30 Yds
• Rushing Yards: Gained 101.00 Yds. Allowed 128.40 Yds
• Passing Yards: Gained 249.80 Yds. Allowed 237.90 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.70. Allowed 21.80
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 7.50. Committed by opponents 6.80
• Penalty Yards: Lost 55.80 Yds. Gained 58.30 Yds

Top American Football Pages