Falcons vs Cardinals Prediction, Picks & Odds | 21 Dec 2025

NFL Betting Preview: Falcons vs Cardinals

The Atlanta Falcons face the Arizona Cardinals at State Farm Stadium, with kickoff scheduled for 16:05 on Sunday, December 21.

Let’s go for Over 48.5 when the Cardinals face the Falcons. We think the line is too generous and we’re expecting the final total to be higher at -105.

Atlanta Falcons triumphed in their previous game. It was on the road where Tampa Bay Buccaneers were beaten 29-28 at Raymond James Stadium. The Falcons recorded 476 yards, breaking down to 365 passing and 111 rushing yards. The offense converted for 27 first downs and reached the end zone 4 times, 3 by pass and one by run.

Arizona Cardinals lost on the road in their last game, making it six straight defeats. Houston Texans won 40-20 at NRG Stadium. The Cardinals totaled 307 yards, with 235 through the air and 72 on the ground. The offense picked up 22 first downs and crossed the goal line 3 times.

Head-to-Head Statistics

The Cardinals beat the Falcons when the teams last met. It was a 25-23 scoreline at State Farm Stadium. The previous 3 H2H meetings have involved the Cardinals winning two times.

Quarterbacks

Kirk Cousins

231.5 Passing Yards

Over -112

Under -112

Jacoby Brissett

258.5 Passing Yards

Over -112

Under -112

Falcons vs Cardinals Prediction & Picks

Get fully prepped for Falcons vs Cardinals with our betting guide, featuring our expert match pick, predicted scoreline, top player props and a value-focused bet builder.

Game Prediction

The best betting angle could be wagering on the totals for this NFL matchup. Our pick is for Over 48.5 points to be scored at odds of -105 which makes lots of appeal.

Our NFL handicappers study recent form and take injuries into account when assessing each matchup. Before delivering a verdict, we combine that insight with the latest stats to strengthen our analysis.

Key Falcons vs Cardinals stats:

• The 48.5 line has been covered in 3 of the last 5 Falcons games.
• The 48.5 line has been covered in the last 2 Falcons games on the road.
• The 48.5 line has been covered in the last 4 Cardinals games at home this season.
• The 48.5 line has been covered in 5 of the last 7 Cardinals games at home this season.
• The 48.5 line has been covered in 7 of the last 10 Cardinals games.

Over 48.5 Probability

If you go by the best betting sites, our pick has a 51.3% chance of winning. Our analysts think there’s a stronger chance of success and calculate the probability to be 55-60%. The bet can be recommended for this precise reason.

Looking for a bigger return on your Total bet? Consider the Result & Total lines where you combine the winning franchise and Over a certain number of points.

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Our Game Prediction

Over 48.5 Points @ -105 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Dec 19, 22:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Jacoby Brissett Over 254.5 Passing Yards -114

You can place a bet on Jacoby Brissett (Cardinals) at -114 to surpass 254.5 passing yards. We believe it makes sense to stick with him on the Over and bettors can be confident in this QB Passing Yards pick.

Latest Jacoby Brissett Player Prop Odds

Touchdown

Anytime

+500

First

+2700

Passing Yards

Over 258.5

-112

Under 258.5

-112

Rushing Yards

Over 12.5

-112

Under 12.5

-112

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Tyler Allgeier Over 29.5 Rushing Yards -114

The odds for Tyler Allgeier (Falcons) to exceed 29.5 rushing yards stand at -114. We can place a Player Rushing Yards bet with confidence, as we expect him to cover the line.

Latest Tyler Allgeier Player Prop Odds

Touchdown

Anytime

+145

First

+850

Rushing Yards

Over 31.5

-112

Under 31.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Falcons 31 - 24 Cardinals

For those looking to get more bang for their buck, consider a correct score bet on the Falcons. Backing them to win 31-24 means you can land a potential monster return.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Falcons vs Cardinals Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Atlanta Falcons are regarded as having a 41% chance of winning this game according to the latest betting odds. The sportsbooks have priced them up at +145. At -175, Arizona Cardinals are regarded as having a lower probability of winning.

The current spread is 3.5 and total points is 46.5. A Total bet is always available and can often provide value selections. If you’re going for Over 46.5, then the odds are -110.

If you’re betting on the National Football League, we recommend visiting the top betting apps and scanning through the many team props and game lines. There’s the opportunity to wager pre-game and in-game.

Moneyline

Falcons

+145

Cardinals

-175

Point Spread

Falcons +3.5

-110

Cardinals -3.5

-110

Total Points

Under 46.5

-110

Over 46.5

-110

Bijan Robinson can be backed to score a touchdown at anytime at -208. He is the favorite to score the first TD at odds of +340.

Touchdown

Bijan Robinson (Falcons)

First TD

+340

Anytime TD

-208

Drake London (Falcons)

First TD

+700

Anytime TD

+135

Trey McBride (Cardinals)

First TD

+800

Anytime TD

+115

Michael Carter (Cardinals)

First TD

+800

Anytime TD

+115

Tyler Allgeier (Falcons)

First TD

+850

Anytime TD

+145

Kyle Pitts (Falcons)

First TD

+950

Anytime TD

+190

Michael Wilson (Cardinals)

First TD

+1100

Anytime TD

+165

Marvin Harrison Jr. (Cardinals)

First TD

+1400

Anytime TD

+230

Darnell Mooney (Falcons)

First TD

+1800

Anytime TD

+420

Jacoby Brissett (Cardinals)

First TD

+2700

Anytime TD

+500

Emari Demercado (Cardinals)

First TD

+3000

Anytime TD

+400

Elijah Higgins (Cardinals)

First TD

+3500

Anytime TD

+650

Jalen Brooks (Cardinals)

First TD

+5500

Anytime TD

+650

Xavier Weaver (Cardinals)

First TD

+5500

Anytime TD

+650

Casey Washington (Falcons)

First TD

+6000

Anytime TD

+1100

David Sills V (Falcons)

First TD

+6000

Anytime TD

+650

Corey Kiner (Cardinals)

First TD

+6500

Anytime TD

+1000

KhaDarel Hodge (Falcons)

First TD

+7000

Anytime TD

+1700

Kirk Cousins (Falcons)

First TD

+8000

Anytime TD

+1800

Feleipe Franks (Falcons)

First TD

+10000

Anytime TD

+3000

Nathan Carter (Falcons)

First TD

+10000

Anytime TD

+3500

Teagan Quitoriano (Falcons)

First TD

+10000

Anytime TD

+3000

Chris Blair (Falcons)

First TD

+10000

Anytime TD

+2200

Deven Thompkins (Falcons)

First TD

+10000

Anytime TD

+2200

Josiah Deguara (Cardinals)

First TD

+10000

Anytime TD

+1500

Pharaoh Brown (Cardinals)

First TD

+10000

Anytime TD

+1500

Charlie Woerner (Falcons)

First TD

+10000

Anytime TD

+1200

Malik Heath (Falcons)

First TD

+10000

Anytime TD

+1600

Dylan Drummond (Falcons)

First TD

+10000

Anytime TD

+1700

Jamal Agnew (Falcons)

First TD

+10000

Anytime TD

+1700

Receiving Yards

Trey McBride (Cardinals)

Over 71.5

-112

Under 71.5

-112

Drake London (Falcons)

Over 66.5

-112

Under 66.5

-112

Michael Wilson (Cardinals)

Over 54.5

-112

Under 54.5

-112

Kyle Pitts (Falcons)

Over 52.5

-112

Under 52.5

-112

Marvin Harrison Jr. (Cardinals)

Over 47.5

-112

Under 47.5

-112

Bijan Robinson (Falcons)

Over 37.5

-112

Under 37.5

-112

Darnell Mooney (Falcons)

Over 25.5

-112

Under 25.5

-112

Elijah Higgins (Cardinals)

Over 8.5

-112

Under 8.5

-112

Rushing Yards

Bijan Robinson (Falcons)

Over 90.5

-112

Under 90.5

-112

Michael Carter (Cardinals)

Over 48.5

-112

Under 48.5

-112

Tyler Allgeier (Falcons)

Over 31.5

-112

Under 31.5

-112

Jacoby Brissett (Cardinals)

Over 12.5

-112

Under 12.5

-112

Kirk Cousins (Falcons)

Over 0.5

+148

Under 0.5

-189

Passing Yards

Jacoby Brissett (Cardinals)

Over 258.5

-112

Under 258.5

-112

Kirk Cousins (Falcons)

Over 231.5

-112

Under 231.5

-112

You don’t have to wait for the final outcome when it comes to NFL micro betting. Instead, there’s the opportunity to wager on live lines which tend to be settled in a shorter space of time and the in-game odds are always changing.

Cardinals Run Includes Six Consecutive Home Losses

The Cardinals are riding a skid of six straight defeats at State Farm Stadium. They have gone 3-7 across their last 10 home games, averaging 24.90 points on offense and surrendering 27.80 on defense.

The Falcons have a 4-6 record in their last 10 games away from home, putting up 19.60 points on average and giving up 21.50.

The last time the Cardinals faced the Falcons at State Farm Stadium, they won 25-23.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Cardinals Home Stats		3-7	52.70	24.90	27.80	6	4
Falcons Away Stats		4-6	41.10	19.60	21.50	4	6

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Latest regular season and playoff games stats.

Atlanta Falcons Stats

Arizona Cardinals Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 1 win and 9 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -2.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -2.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +2.5 Betting Line: Have covered the spread in 2 of the last 10 games
• +2.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 46.00 pts in the previous 10 games
• Game Totals on the Road: An average of 41.10 pts in the previous 10 games on the road
• Over 48.5: Covered in 4 of the previous 10 games
• Over 48.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.50 pts and allowed 25.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.60 pts and allowed 21.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 53.40 pts in the previous 10 games
• Game Totals at Home: An average of 52.70 pts in the previous 10 home games
• Over 48.5: Covered in 7 of the previous 10 games
• Over 48.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 22.00 pts and allowed 31.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.90 pts and allowed 27.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 331.50 Yds. Allowed 355.40 Yds
• Rushing Yards: Gained 117.20 Yds. Allowed 135.50 Yds
• Passing Yards: Gained 214.30 Yds. Allowed 219.90 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 1.20 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 19.40. Allowed 21.90
• Total Turnovers: Committed 1.00. Committed by opponents 1.10
• Total Penalties: Committed 7.10. Committed by opponents 5.50
• Penalty Yards: Lost 56.30 Yds. Gained 44.30 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 358.60 Yds. Allowed 350.90 Yds
• Rushing Yards: Gained 90.70 Yds. Allowed 135.90 Yds
• Passing Yards: Gained 267.90 Yds. Allowed 215.00 Yds
• Total Touchdowns: Scored 2.70 TD. Allowed 3.60 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 21.80. Allowed 21.60
• Total Turnovers: Committed 1.50. Committed by opponents 1.30
• Total Penalties: Committed 6.50. Committed by opponents 5.30
• Penalty Yards: Lost 50.60 Yds. Gained 42.90 Yds

Last 10 Games on the Road

• Total Yards: Gained 329.30 Yds. Allowed 315.70 Yds
• Rushing Yards: Gained 131.50 Yds. Allowed 135.30 Yds
• Passing Yards: Gained 197.80 Yds. Allowed 180.40 Yds
• Total Touchdowns: Scored 2.10 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.20 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.00 TD
• Total 1st Downs: Picked up 19.60. Allowed 20.60
• Total Turnovers: Committed 1.10. Committed by opponents 1.70
• Total Penalties: Committed 6.10. Committed by opponents 6.30
• Penalty Yards: Lost 45.90 Yds. Gained 48.40 Yds

Last 10 Home Games

• Total Yards: Gained 350.80 Yds. Allowed 366.30 Yds
• Rushing Yards: Gained 101.00 Yds. Allowed 128.40 Yds
• Passing Yards: Gained 249.80 Yds. Allowed 237.90 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 20.70. Allowed 21.80
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 7.50. Committed by opponents 6.80
• Penalty Yards: Lost 55.80 Yds. Gained 58.30 Yds

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