San Francisco 49ers
American Football NFL Lumen Field Sun 7 Sep 16:05
Seattle Seahawks
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Live Stream
  7. Team News
  8. Lineups
  9. Injuries
  10. Standings

NFL Betting Preview: Niners vs Seahawks

The San Francisco 49ers meet the Seattle Seahawks in this NFL Week 1 matchup at Lumen Field, with kickoff scheduled for 16:05 on Sunday 7 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Why Seahawks Can Claim the Win

Our betting prediction is that there will be home-field advantage when the Seahawks face the Niners. You can currently get -100 about this happening which look like great odds.

Backing Seahawks? Don’t miss the chance to use the latest BetMGM promo code and be sure to check out our comprehensive review too.

Seahawks Won Last H2H Encounter

San Francisco 49ers suffered a defeat in their previous game. A 47-24 scoreline occurred on the road at State Farm Stadium against Arizona Cardinals. The Niners recorded 436 yards, with 298 through the air and 138 on the ground. They picked up 26 first downs and found the end zone 3 times.

Seattle Seahawks won their last game 30-25. This was a road victory at SoFi Stadium against Los Angeles Rams. The Seahawks moved the ball for 336 yards, breaking down to 210 passing and 126 rushing yards. The offense moved the chains 18 times and struck for 4 touchdowns.

Head-to-Head Statistics

The Seahawks triumphed 20-17 when they last played the Niners. This head-to-head was played at Levi's Stadium. The Niners have won six of the past 10 games that these teams have played.

Quarterbacks

49ers vs Seahawks Prediction & Picks

Discover our expert 49ers vs Seahawks betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.

Game Prediction

There are lots of reasons to support the pick that the Seahawks will win this NFL matchup. Therefore, we’re heading to the Moneyline where you can get -100.

Getting the lowdown on injuries and analyzing the form guide are key steps before making NFL picks. We also put strong emphasis on stats, where a data-led approach often leads to smarter predictions.

Key 49ers vs Seahawks stats:

  • Seahawks have won 6 of their last 10 games.
  • Seahawks have won 12 of their last 20 games.
  • Seahawks have won 2 consecutive games.
  • 49ers have lost their last 4 games.
  • 49ers have lost 7 of their last 10 games.
  • 49ers have lost 12 of their last 20 games.

Seahawks Moneyline Probability

When you look at the latest betting odds, our pick has a 50% chance of winning. Our cappers think there’s a stronger chance of success and calculate the probability to be 55-60%. It’s why we think it’s worth placing this bet.

Looking for Bigger Odds?

Fancy the Seahawks to triumph but want more juice in the odds? Why not take a look at the spread and consider them to cover one of the available lines.

Before your next wager, read our guide featuring today’s top betting offers, free bet deals, and sign-up bonuses.

Best Bet

Seahawks Moneyline @ -100 Watch Live Bet Now BetMGM logo
BetMGM logo
BetMGM Promo Up To $1500 in Bonus Bets Get Bonus T&C apply. Gamble responsibly 18+
Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.
Published 22:26, 05 September 2025

Player Prop Picks

Top Pick: Sam Darnold Over 206.5 Passing Yards -114 BetMGM logo

The odds for Sam Darnold (Seahawks) to record more than 206.5 passing yards are -114. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Sam Darnold Player Prop Odds

Kenneth Walker III Anytime TD +125 BetMGM logo

Kenneth Walker III (Seahawks) is available at +125 to score a TD. Attractive odds are available for this Anytime Touchdown Scorer wager, and we believe it's a value proposition for him to take it to the house.

Latest Kenneth Walker III Player Prop Odds

Same Game Parlay Picks

Moneyline Seahawks
Totals Over 43.5
Passing Yards Sam Darnold Over 206.5

Our same game parlay pick includes Seahawks on the moneyline, Over 43.5 and Sam Darnold (Seahawks) to go Over 206.5 passing yards.

There are lots of options when you place a same game parlay. You can go through the football lines and identify your favorite picks before combining the odds on the bet slip. Personalised wagering doesn’t come any better.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

49ers 49ers logo 20 - 27 Seahawks logo Seahawks

We’re going for the Seahawks to win by a 27-20 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

49ers vs Seahawks Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Predicting a Close Encounter

The betting odds about Seattle Seahawks winning is -100, with San Francisco 49ers priced up at -118 to achieve victory. In the eyes of the leading sportsbooks, the home team are regarded as 50% likely to claim a victory.

1.5 is the spread and 43.5 is the total points line. NFL fans regularly enjoy the opportunity to bet on the Totals. Those expecting a low total can back Under 43.5 at -118.

The best NFL sportsbooks offer a wide range of team props and game lines for every matchup. Make sure you look through all the available options before deciding which bet to place.

Christian McCaffrey Favorite to Be First TD Scorer

The First TD Scorer favorite is Christian McCaffrey at +550. Similar odds can be found if you’re interested in this player to register the last touchdown.

Touchdown

Christian McCaffrey (49ers)
First TD
+550
Anytime TD
-100
BetMGM Logo
Kenneth Walker III (Seahawks)
First TD
+650
Anytime TD
+125
BetMGM Logo
Jaxon Smith-Njigba (Seahawks)
First TD
+750
Anytime TD
+140
BetMGM Logo
George Kittle (49ers)
First TD
+900
Anytime TD
+175
BetMGM Logo

Receiving Yards

George Kittle (49ers)
Over 62.5
-114
Under 62.5
-114
BetMGM Logo
Jaxon Smith-Njigba (Seahawks)
Over 60.5
-114
Under 60.5
-114
BetMGM Logo
Jauan Jennings (49ers)
Over 49.5
-114
Under 49.5
-114
BetMGM Logo
Ricky Pearsall (49ers)
Over 44.5
-114
Under 44.5
-114
BetMGM Logo

Rushing Yards

Christian McCaffrey (49ers)
Over 64.5
-114
Under 64.5
-114
BetMGM Logo
Kenneth Walker III (Seahawks)
Over 62.5
-114
Under 62.5
-114
BetMGM Logo
Zach Charbonnet (Seahawks)
Over 30.5
-114
Under 30.5
-114
BetMGM Logo

Passing Yards

Best Betting Offers
Lumen Field
Lumen Field

Niners Hold Edge in Recent Head-to-Head Matchups at Lumen Field

The Seahawks have gone 3-7 across their last 10 home games, putting up 20.00 points on average and giving up 23.80.

The Niners have dropped four road games in a row. They have a 3-7 record in their last 10 games away from home, posting 21.00 points per contest while yielding 27.80.

The previous meeting at Lumen Field saw the Niners defeat the Seahawks 36-24. Looking back at the last 6 head-to-head meetings at Lumen Field, the Niners have posted four victories, while the Seahawks have logged two.

Last 10 Games W-L P PF PA O43.5 U43.5
Seahawks logo Seahawks Home Stats 3-7 43.80 20.00 23.80 6 4
49ers logo 49ers Away Stats 3-7 48.80 21.00 27.80 7 3
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O43.5 = Games Over 43.5 Points
  • U43.5 = Games Under 43.5 Points
Team Stats

Latest regular season and playoff games stats.

San Francisco 49ers logo San Francisco 49ers Stats
Seattle Seahawks logo Seattle Seahawks Stats
Moneyline
  • 3 wins and 7 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 games on the road
Moneyline
  • 6 wins and 4 defeats in the last 10 games
  • 3 wins and 7 defeats in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points
Game Stats
Last 10 Games
Game Stats
Last 10 Games
Last 10 Games on the Road
Last 10 Home Games

Live Streaming

You can watch and bet on NFL games thanks to the live streaming service that’s available. This is only available to eligible sportsbook customers and is subject to geo-restrictions.

Fans love the opportunity to watch thousands of sporting events per year with the best betting apps.

Team News

San Francisco 49ers Injuries

Type
Name
Info
Brandon Aiyuk
Knee - ACL + MCL
Isaac Alarcon
Suspension
Jacob Cowing
Hamstring
Russell Gage
Knee - MCL
Kevin Givens
Pectoral
Tarron Jackson
Undisclosed
Jordan James
Finger
Christian McCaffrey
Calf
Malik Mustapha
Knee - ACL
Demarcus Robinson
Suspension
Jakob Robinson
Forearm
Kurtis Rourke
Knee
Patrick Taylor
Shoulder
Trent Taylor
Undisclosed
Tre Tomlinson
Undisclosed
Jordan Watkins
Ankle

Seattle Seahawks Injuries

Type
Name
Info
Jake Bobo
Concussion
AJ Finley
Knee
Johnathan Hankins
Back
Christian Haynes
Pectoral
Kenny McIntosh
Knee - ACL
Rylie Mills
Knee - ACL
Uchenna Nwosu
Knee
Dareke Young
Hamstring

Previous San Francisco 49ers Lineups

05 Jan NFL
49ers 24-47 Cardinals
30 Dec NFL
Lions 40-34 49ers
22 Dec NFL
49ers 17-29 Dolphins
12 Dec NFL
Rams 12-6 49ers
08 Dec NFL
Bears 13-38 49ers
01 Dec NFL
49ers 10-35 Bills
24 Nov NFL
49ers 10-38 Packers
17 Nov NFL
Seahawks 20-17 49ers
10 Nov NFL
49ers 23-20 Buccaneers
27 Oct NFL
Cowboys 24-30 49ers

Previous Seattle Seahawks Lineups

05 Jan NFL
Seahawks 30-25 Rams
26 Dec NFL
Seahawks 6-3 Bears
22 Dec NFL
Vikings 27-24 Seahawks
15 Dec NFL
Packers 30-13 Seahawks
08 Dec NFL
Seahawks 30-18 Cardinals
01 Dec NFL
Seahawks 26-21 Jets
24 Nov NFL
Cardinals 6-16 Seahawks
17 Nov NFL
Seahawks 20-17 49ers
03 Nov NFL
Rams 26-20 Seahawks
27 Oct NFL
Bills 31-10 Seahawks

NFL Standings Select Season

AFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC East W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC North W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC South W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
NFC West W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
AFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFC Conference W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
NFL Team W L T PCT PF PA N. Pts Home Road Div Conf Last 5 Strk
Chargers 1 0 0 1.000 27 21 6 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Eagles 1 0 0 1.000 24 20 4 1-0-0 0-0-0 1-0-0 1-0-0 1-0-0 1W
Cardinals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Falcons 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Ravens 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bills 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Panthers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bears 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Bengals 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Browns 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Broncos 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Lions 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Packers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Texans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Colts 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jaguars 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Raiders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Rams 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Dolphins 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Vikings 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Patriots 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Saints 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Giants 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Jets 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Steelers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
49ers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Seahawks 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Buccaneers 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Titans 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Commanders 0 0 0 - 0 0 0 0-0-0 0-0-0 0-0-0 0-0-0 - -
Cowboys 0 1 0 0.000 20 24 -4 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L
Chiefs 0 1 0 0.000 21 27 -6 0-0-0 0-1-0 0-1-0 0-1-0 0-1-0 1L