49ers vs Seahawks Prediction, Picks & Odds | 07 Sep 2025

NFL Betting Preview: Niners vs Seahawks

The San Francisco 49ers meet the Seattle Seahawks in this NFL Week 1 matchup at Lumen Field, with kickoff scheduled for 16:05 on Sunday, September 7. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Our betting prediction is that there will be home-field advantage when the Seahawks face the Niners. You can currently get -100 about this happening which look like great odds.

San Francisco 49ers suffered a defeat in their previous game. A 47-24 scoreline occurred on the road at State Farm Stadium against Arizona Cardinals. The Niners recorded 436 yards, with 298 through the air and 138 on the ground. They picked up 26 first downs and found the end zone 3 times.

Seattle Seahawks won their last game 30-25. This was a road victory at SoFi Stadium against Los Angeles Rams. The Seahawks moved the ball for 336 yards, breaking down to 210 passing and 126 rushing yards. The offense moved the chains 18 times and struck for 4 touchdowns.

Head-to-Head Statistics

The Seahawks triumphed 20-17 when they last played the Niners. This head-to-head was played at Levi's Stadium. The Niners have won six of the past 10 games that these teams have played.

Quarterbacks

Brock Purdy

243.5 Passing Yards

Over -112

Under -112

Sam Darnold

206.5 Passing Yards

Over -112

Under -112

49ers vs Seahawks Prediction & Picks

Discover our expert 49ers vs Seahawks betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.

Game Prediction

There are lots of reasons to support the pick that the Seahawks will win this NFL matchup. Therefore, we’re heading to the Moneyline where you can get -100.

Getting the lowdown on injuries and analyzing the form guide are key steps before making NFL picks. We also put strong emphasis on stats, where a data-led approach often leads to smarter predictions.

Key 49ers vs Seahawks stats:

• Seahawks have won 6 of their last 10 games.
• Seahawks have won 12 of their last 20 games.
• Seahawks have won 2 consecutive games.
• 49ers have lost their last 4 games.
• 49ers have lost 7 of their last 10 games.
• 49ers have lost 12 of their last 20 games.

Seahawks Moneyline Probability

When you look at the latest betting odds, our pick has a 50% chance of winning. Our cappers think there’s a stronger chance of success and calculate the probability to be 55-60%. It’s why we think it’s worth placing this bet.

Fancy the Seahawks to triumph but want more juice in the odds? Why not take a look at the spread and consider them to cover one of the available lines.

Before your next wager, read our guide featuring today’s top betting offers, free bet deals, and sign-up bonuses.

Our Game Prediction

Seahawks Moneyline @ -100 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 5, 22:26). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Sam Darnold Over 206.5 Passing Yards -114

The odds for Sam Darnold (Seahawks) to record more than 206.5 passing yards are -114. The line for QB Passing Yards looks attractive and we’re confident of securing a return.

Latest Sam Darnold Player Prop Odds

Touchdown

Anytime

+900

First

+3500

Passing Yards

Over 206.5

-112

Under 206.5

-112

Rushing Yards

Over 9.5

-112

Under 9.5

-112

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Kenneth Walker III Anytime TD +125

Kenneth Walker III (Seahawks) is available at +125 to score a TD. Attractive odds are available for this Anytime Touchdown Scorer wager, and we believe it's a value proposition for him to take it to the house.

Latest Kenneth Walker III Player Prop Odds

Touchdown

Anytime

+135

First

+700

Receiving Yards

Over 13.5

-112

Under 13.5

-112

Rushing Yards

Over 59.5

-112

Under 59.5

-112

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

49ers 20 - 27 Seahawks

We’re going for the Seahawks to win by a 27-20 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

49ers vs Seahawks Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

The betting odds about Seattle Seahawks winning is +112, with San Francisco 49ers priced up at -132 to achieve victory. In the eyes of the leading sportsbooks, the home team are regarded as 47% likely to claim a victory.

1.5 is the spread and 43.5 is the total points line. NFL fans regularly enjoy the opportunity to bet on the Totals. Those expecting a low total can back Under 43.5 at -118.

The best NFL sportsbooks offer a wide range of team props and game lines for every matchup. Make sure you look through all the available options before deciding which bet to place.

Moneyline

49ers

-132

Seahawks

+112

Point Spread

49ers -1.5

-120

Seahawks +1.5

-102

Total Points

Under 43.5

-118

Over 43.5

-104

The First TD Scorer favorite is Christian McCaffrey at +430. Similar odds can be found if you’re interested in this player to register the last touchdown.

Touchdown

Christian McCaffrey (49ers)

First TD

+430

Anytime TD

-125

Kenneth Walker III (Seahawks)

First TD

+700

Anytime TD

+135

Jaxon Smith-Njigba (Seahawks)

First TD

+800

Anytime TD

+150

George Kittle (49ers)

First TD

+900

Anytime TD

+180

Jauan Jennings (49ers)

First TD

+1100

Anytime TD

+220

Ricky Pearsall (49ers)

First TD

+1100

Anytime TD

+230

Cooper Kupp (Seahawks)

First TD

+1200

Anytime TD

+230

Zach Charbonnet (Seahawks)

First TD

+1700

Anytime TD

+390

AJ Barner (Seahawks)

First TD

+1800

Anytime TD

+380

Jordan Watkins (49ers)

First TD

+2200

Anytime TD

+490

Tory Horton (Seahawks)

First TD

+2200

Anytime TD

+460

Brock Purdy (49ers)

First TD

+2500

Anytime TD

+600

Brian Robinson Jr. (49ers)

First TD

+2700

Anytime TD

+500

Jake Bobo (Seahawks)

First TD

+3000

Anytime TD

+650

Marquez Valdes-Scantling (Seahawks)

First TD

+3500

Anytime TD

+1000

Elijah Arroyo (Seahawks)

First TD

+3500

Anytime TD

+800

Sam Darnold (Seahawks)

First TD

+3500

Anytime TD

+900

Luke Farrell (49ers)

First TD

+4500

Anytime TD

+1200

Russell Gage (49ers)

First TD

+6000

Anytime TD

+1500

Kyle Juszczyk (49ers)

First TD

+6500

Anytime TD

+1400

Brayden Willis (49ers)

First TD

+6500

Anytime TD

+1600

Skyy Moore (49ers)

First TD

+7000

Anytime TD

+1800

Robbie Ouzts (Seahawks)

First TD

+8000

Anytime TD

+2000

Jake Tonges (49ers)

First TD

+8000

Anytime TD

+2200

Isaac Guerendo (49ers)

First TD

+8000

Anytime TD

+1700

Cody White (Seahawks)

First TD

+8000

Anytime TD

+2000

George Holani (Seahawks)

First TD

+10000

Anytime TD

+2500

Eric Saubert (49ers)

First TD

+10000

Anytime TD

+2500

Nick Kallerup (Seahawks)

First TD

+10000

Anytime TD

+1700

Dareke Young (Seahawks)

First TD

+10000

Anytime TD

+1700

Receiving Yards

George Kittle (49ers)

Over 63.5

-112

Under 63.5

-112

Jaxon Smith-Njigba (Seahawks)

Over 60.5

-112

Under 60.5

-112

Jauan Jennings (49ers)

Over 48.5

-112

Under 48.5

-112

Ricky Pearsall (49ers)

Over 44.5

-112

Under 44.5

-112

Cooper Kupp (Seahawks)

Over 39.5

-112

Under 39.5

-112

Christian McCaffrey (49ers)

Over 29.5

-112

Under 29.5

-112

Tory Horton (Seahawks)

Over 23.5

-112

Under 23.5

-112

AJ Barner (Seahawks)

Over 21.5

-112

Under 21.5

-112

Kenneth Walker III (Seahawks)

Over 13.5

-112

Under 13.5

-112

Zach Charbonnet (Seahawks)

Over 9.5

-112

Under 9.5

-112

Rushing Yards

Christian McCaffrey (49ers)

Over 62.5

-112

Under 62.5

-112

Kenneth Walker III (Seahawks)

Over 59.5

-112

Under 59.5

-112

Zach Charbonnet (Seahawks)

Over 29.5

-112

Under 29.5

-112

Brock Purdy (49ers)

Over 12.5

-112

Under 12.5

-112

Sam Darnold (Seahawks)

Over 9.5

-112

Under 9.5

-112

Passing Yards

Brock Purdy (49ers)

Over 243.5

-112

Under 243.5

-112

Sam Darnold (Seahawks)

Over 206.5

-112

Under 206.5

-112

It’s possible to use stats to your advantage when it comes to NFL micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live team, score and player props and see if you can find an angle.

Niners Hold Edge in Recent Head-to-Head Matchups at Lumen Field

The Seahawks have gone 3-7 across their last 10 home games, putting up 20.00 points on average and giving up 23.80.

The Niners have dropped four road games in a row. They have a 3-7 record in their last 10 games away from home, posting 21.00 points per contest while yielding 27.80.

The previous meeting at Lumen Field saw the Niners defeat the Seahawks 36-24. Looking back at the last 6 head-to-head meetings at Lumen Field, the Niners have posted four victories, while the Seahawks have logged two.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
Seahawks Home Stats		6-4	50.10	28.20	21.90	6	4
49ers Away Stats		8-2	48.80	27.50	21.30	6	4

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Seattle Seahawks Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +7 Betting Line: Have covered the spread in 8 of the last 10 games
• +7 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -7 Betting Line: Have covered the spread in 6 of the last 10 games
• -7 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 52.60 pts in the previous 10 games
• Game Totals on the Road: An average of 48.80 pts in the previous 10 games on the road
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 on the Road: Covered in 6 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.00 pts and allowed 22.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 27.50 pts and allowed 21.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 44.60 pts in the previous 10 games
• Game Totals at Home: An average of 50.10 pts in the previous 10 home games
• Over 44.5: Covered in 5 of the previous 10 games
• Over 44.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 29.00 pts and allowed 15.60 pts in the last 10 games
• Team Totals at Home: Have scored an average of 28.20 pts and allowed 21.90 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 354.00 Yds. Allowed 339.40 Yds
• Rushing Yards: Gained 117.10 Yds. Allowed 111.00 Yds
• Passing Yards: Gained 236.90 Yds. Allowed 228.40 Yds
• Total Touchdowns: Scored 3.70 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 1.00 TD
• Passing Touchdowns: Scored 2.40 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 23.10. Allowed 20.60
• Total Turnovers: Committed 1.20. Committed by opponents 0.90
• Total Penalties: Committed 3.60. Committed by opponents 6.20
• Penalty Yards: Lost 27.80 Yds. Gained 42.20 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 351.90 Yds. Allowed 271.40 Yds
• Rushing Yards: Gained 135.30 Yds. Allowed 102.80 Yds
• Passing Yards: Gained 216.60 Yds. Allowed 168.60 Yds
• Total Touchdowns: Scored 2.90 TD. Allowed 1.70 TD
• Rushing Touchdowns: Scored 1.10 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 20.40. Allowed 15.50
• Total Turnovers: Committed 1.60. Committed by opponents 1.70
• Total Penalties: Committed 5.40. Committed by opponents 6.40
• Penalty Yards: Lost 40.40 Yds. Gained 48.50 Yds

Last 10 Games on the Road

• Total Yards: Gained 342.90 Yds. Allowed 346.70 Yds
• Rushing Yards: Gained 94.40 Yds. Allowed 103.40 Yds
• Passing Yards: Gained 248.50 Yds. Allowed 243.30 Yds
• Total Touchdowns: Scored 3.10 TD. Allowed 2.50 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.70 TD
• Passing Touchdowns: Scored 2.30 TD. Allowed 1.80 TD
• Total 1st Downs: Picked up 21.80. Allowed 20.00
• Total Turnovers: Committed 1.00. Committed by opponents 1.30
• Total Penalties: Committed 4.80. Committed by opponents 6.80
• Penalty Yards: Lost 35.10 Yds. Gained 46.80 Yds

Last 10 Home Games

• Total Yards: Gained 321.50 Yds. Allowed 330.80 Yds
• Rushing Yards: Gained 109.40 Yds. Allowed 94.70 Yds
• Passing Yards: Gained 212.10 Yds. Allowed 236.10 Yds
• Total Touchdowns: Scored 3.00 TD. Allowed 2.30 TD
• Rushing Touchdowns: Scored 1.20 TD. Allowed 0.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 19.50. Allowed 20.00
• Total Turnovers: Committed 2.10. Committed by opponents 1.30
• Total Penalties: Committed 6.40. Committed by opponents 7.20
• Penalty Yards: Lost 55.30 Yds. Gained 56.20 Yds

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