American vs Lafayette Prediction, Picks & Odds | 22 Feb 2026

College Basketball Betting Preview: American vs Lafayette

The American Eagles go up against the Lafayette Leopards, with tip-off scheduled for 12:00 on Sunday, February 22.

We’re very excited to see American at -4.5 on the spread and think it’s a really good number for them to cover against Lafayette at odds of -108.

American Eagles won their previous game by a 75-57 scoreline. It was on the road against Bucknell Bison.

Lafayette Leopards triumphed in their last game. It was on the road where Holy Cross Crusaders were beaten 86-83.

Head-to-Head Statistics

Lafayette beat American when the teams last met. It was a 67-65 scoreline. The past 10 games H2H record shows that both teams have five wins.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
American	15-13	2101	2001	100	11-4	4-9	2W
Lafayette	9-19	1931	2078	-147	5-8	4-11	1W

View Full Standings

American vs Lafayette Prediction & Picks

The American vs Lafayette betting tips feature sharp analysis across major markets, including a key match prediction, correct score guidance and a ready-made bet builder.

Game Prediction

Don’t miss out on the opportunity to side with American at -4.5 on the spread. On the face of it, this seems a more than generous line and -108 can be backed for this college matchup.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant college hoops stats, this gives us a strong foundation for accurate basketball picks.

Key American vs Lafayette stats:

• The -4.5 line has been covered by American in 2 consecutive games.
• The +4.5 line hasn’t been covered by Lafayette in 3 consecutive games at home.
• The +4.5 line hasn’t been covered by Lafayette in 6 of their last 10 games at home.
• The +4.5 line hasn’t been covered by Lafayette in 11 of their last 20 games.

American -4.5 Probability

According to the best sportsbooks, there’s a 51.8% likelihood of our pick landing a return. However, our cappers think that the probability is close to 60% taking all factors into consideration. It’s why we think it’s worth placing this college basketball wager.

If you want to secure a bigger potential payout on your wager, there’s the possibility to move the line. Take a look at the various prices and see which spread you think will be covered.

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Our Game Prediction

American -4.5 @ -108 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Feb 21, 21:03). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

American 78 - 70 Lafayette

A 78-70 win for American is clearly a risky bet although this could be an exciting correct score option where there’s the chance to enjoy a huge potential return.

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American vs Lafayette Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

Lafayette are strong +172 favorites to win this college game according to the Moneyline betting odds. The sportsbooks give them a 37% chance of claiming victory. American are regarded as a long shot to win and you can currently back them at -208.

The spread is calculated to be 4.5, while total points comes in at 140.5. A Total wager relates to the number of points that will be scored overall. If you’re wanting to back Over 140.5, the odds are -110.

If you’re wagering on college basketball, we recommend heading to the top betting apps and scanning through the many game lines and team props. There’s a chance to wager pre-game and in-game.

Moneyline

American

-208

Lafayette

+172

Point Spread

American -4.5

-105

Lafayette +4.5

-115

Total Points

Under 140.5

-110

Over 140.5

-110

As an alternative to the game lines and team props, check out the player props that are available. These can be a great alternative if you want to focus on a player’s performance. The best gambling sites will provide lots of options.

Micro betting is an exciting way to wager on college basketball. There are many live lines and it’s a simple case of predicting what is going to happen. Next Field Goal, where you select if the shot will be a two or three-pointer are among the options.

Latest regular season and playoff games stats.

American Stats

Lafayette Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 home games

Point Spread

• -4.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -4.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +4.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +4.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 141.70 pts in the previous 10 games
• Game Totals on the Road: An average of 147.80 pts in the previous 10 games on the road
• Over 140.5: Covered in 5 of the previous 10 games
• Over 140.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 72.10 pts and allowed 69.60 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 71.20 pts and allowed 76.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 137.00 pts in the previous 10 games
• Game Totals at Home: An average of 138.90 pts in the previous 10 home games
• Over 140.5: Covered in 4 of the previous 10 games
• Over 140.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 67.60 pts and allowed 69.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 68.00 pts and allowed 70.90 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Patriot League	Overall	PF	PA	N. Pts	Home	Away	Strk
Navy	23-6	2156	1843	313	13-2	10-4	11W
Colgate	16-12	2131	2104	27	9-4	7-8	1W
American	15-13	2101	2001	100	11-4	4-9	2W
Boston University	13-15	2145	2097	48	9-5	4-10	5W
Lehigh	12-16	2034	2101	-67	8-4	4-12	1L
Loyola Maryland	11-18	2203	2236	-33	8-6	3-12	2L
Army	11-18	2104	2248	-144	6-10	5-8	1L
Lafayette	9-19	1931	2078	-147	5-8	4-11	1W
Holy Cross	9-20	1965	2147	-182	6-7	3-13	3L
Bucknell	8-20	1872	2155	-283	5-8	3-12	4L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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