Clemson vs West Virginia Prediction, Picks & Odds | 21 Nov 2025

College Basketball Betting Preview: Clemson vs West Virginia

The Clemson Tigers battle the West Virginia Mountaineers, with tip-off scheduled for 18:30 on Friday, November 21.

The best bet could involve backing West Virginia against the spread. There’s an attractive +3.5 available at -102 that they cover the line against Clemson and that has to be our prediction.

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Clemson Tigers previous game saw them claim a 81-61 home win over North Alabama Lions.

West Virginia Mountaineers last game saw them claim a 81-59 home win over Lafayette Leopards.

Head-to-Head Statistics

West Virginia beat Clemson in their last head-to-head matchup. It was a 66-59 scoreline.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
West Virginia	5-0	364	274	90	5-0	0-0	5W
Clemson	4-1	423	293	130	4-0	0-1	1W

View Full Standings

Clemson vs West Virginia Prediction & Picks

We’ve got your Clemson vs West Virginia bets covered, including our expert match prediction, correct score recommendation and a hand-picked bet builder tailored for value.

Game Prediction

We’re confident that West Virginia can either win or suffer a narrow defeat in this college matchup. That makes the underdogs at +3.5 the best pick and odds of -102 are available.

We closely track recent form and look for patterns that may impact the outcome. The same goes for injuries to key players. When combined with the most relevant college hoops stats, this gives us a strong foundation for accurate basketball picks.

Key Clemson vs West Virginia stats:

• The +3.5 line has been covered by WVU in 5 consecutive games.
• The +3.5 line has been covered by WVU in 8 of their last 10 games.
• The +3.5 line has been covered by WVU in 15 of their last 20 games at home.
• The -3.5 line hasn’t been covered by Clemson in 2 consecutive games on the road.

WVU +3.5 Probability

The top sportsbooks make it a 50.5% chance that our pick is settled as a winner. Based on our analysts in-depth research, we calculate the actual probability to be 55-60%. This is why we regard this as a value wager.

If you want to pimp the odds about WVU covering the line, you might consider going down the Bet Builder route and combine this prediction with other selections.

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Our Game Prediction

West Virginia +3.5 @ -102 Bet Now

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Correct Score Prediction

Clemson 69 - 71 West Virginia

A close game could be on the cards. We’ll bet on the Mountaineers to secure a 71-69 win at huge odds and this correct score selection should hopefully be a fun one.

Clemson vs West Virginia Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Clemson are -208 favorites and that means a 68% chance of winning this college game according to the Moneyline betting odds with the sportsbooks. The market suggests that West Virginia are least likely to win at +172.

The spread is 3.5 and the total points line is currently 134.5. Having a wager on the Totals is one of the most popular basketball bets. If you’re wanting to back Over 134.5, the odds are -115.

College basketball bettors are spoilt for choice thanks to the huge selection of game lines and team props which are available for most matchups on the coupon. Head to the top betting apps and find the best value picks.

Moneyline

Clemson

-208

WVU

+172

Point Spread

Clemson -3.5

-120

WVU +3.5

-102

Total Points

Under 134.5

-105

Over 134.5

-115

Should you be more interested in a specific individual who is competing, check out the gambling sites’ prop bets where you can pick out player lines that focus on performance rather than the game result.

For those looking to enjoy a thrilling in-game wager, college basketball micro betting could be up your street. You are now able to wager on the Next Field Goal, with the options being for a two-pointer or a three-pointer.

Latest regular season and playoff games stats.

Clemson Stats

West Virginia Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 8 wins and 2 defeats in the last 10 home games

Point Spread

• -3.5 Betting Line: Have covered the spread in 6 of the last 10 games
• -3.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• +3.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +3.5 Betting Line at Home: Have covered the spread in 8 of the last 10 home games

Total Points

• Game Totals: An average of 137.10 pts in the previous 10 games
• Game Totals on the Road: An average of 138.10 pts in the previous 10 games on the road
• Over 133.5: Covered in 7 of the previous 10 games
• Over 133.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 76.30 pts and allowed 60.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 73.50 pts and allowed 64.60 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 130.30 pts in the previous 10 games
• Game Totals at Home: An average of 129.30 pts in the previous 10 home games
• Over 133.5: Covered in 4 of the previous 10 games
• Over 133.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 69.60 pts and allowed 60.70 pts in the last 10 games
• Team Totals at Home: Have scored an average of 70.00 pts and allowed 59.30 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big 12	Overall	PF	PA	N. Pts	Home	Away	Strk
Iowa State	4-0	382	249	133	3-0	1-0	4W
Houston	5-0	382	267	115	4-0	1-0	5W
Oklahoma State	5-0	464	365	99	5-0	0-0	5W
West Virginia	5-0	364	274	90	5-0	0-0	5W
Kansas State	5-0	472	391	81	5-0	0-0	5W
Arizona	5-0	410	335	75	3-0	2-0	5W
Cincinnati	4-0	314	244	70	4-0	0-0	4W
Colorado	4-0	377	329	48	4-0	0-0	4W
Baylor	3-0	268	231	37	3-0	0-0	3W
UCF	5-1	522	467	55	4-1	1-0	4W
Utah	5-1	518	481	37	5-1	0-0	1L
Texas Tech	4-1	437	364	73	4-0	0-1	2W
BYU	3-1	338	273	65	3-1	0-0	1L
Arizona State	3-1	302	269	33	3-1	0-0	1W
TCU	3-2	400	318	82	3-2	0-0	1W
Kansas	3-2	387	319	68	3-0	0-2	1L

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	5-0	462	301	161	4-0	1-0	5W
NC State	4-0	403	279	124	4-0	0-0	4W
North Carolina	5-0	440	316	124	5-0	0-0	5W
Virginia	4-0	363	246	117	4-0	0-0	4W
Syracuse	4-0	326	213	113	3-0	1-0	4W
Virginia Tech	5-0	461	364	97	5-0	0-0	5W
SMU	5-0	460	370	90	5-0	0-0	5W
Stanford	4-0	350	281	69	4-0	0-0	4W
Louisville	4-0	412	284	128	4-0	0-0	4W
California	4-1	420	348	72	4-0	0-1	1W
Georgia Tech	4-1	355	315	40	4-0	0-1	1W
Clemson	4-1	423	293	130	4-0	0-1	1W
Notre Dame	4-1	418	338	80	4-0	0-1	1W
Miami	4-1	456	345	111	4-0	0-1	1W
Florida State	3-1	372	291	81	3-0	0-1	1W
Pittsburgh	4-2	430	383	47	4-0	0-2	1L
Wake Forest	3-2	445	383	62	3-0	0-2	1L
Boston College	3-2	352	313	39	2-1	1-1	2W

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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