DePaul vs Butler Prediction, Picks & Odds | 20 Jan 2026

College Basketball Betting Preview: DePaul vs Butler

The DePaul Blue Demons face the Butler Bulldogs, with tip-off scheduled for 19:30 on Tuesday, January 20.

Back Butler with a -8.5 spread when they face DePaul. This is a good number and we are confident the favorites can cover the line at odds of -105.

DePaul Blue Demons previous game saw them claim a 80-75 home win over Marquette Golden Eagles.

Butler Bulldogs triumphed in their last game. It was on the road where Seton Hall Pirates were beaten 77-66.

Head-to-Head Statistics

Butler had the edge in the most recent matchup between these teams. They recorded a 84-72 win over DePaul. Butler have a 100% win record when it comes to the previous 10 H2H meetings.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Butler	16-16	2540	2481	59	13-8	3-8	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L

View Full Standings

DePaul vs Butler Prediction & Picks

Prepare for DePaul vs Butler with our expert betting guide featuring a trusted match prediction, a correct score recommendation and a well-crafted bet builder.

Game Prediction

There’s a great opportunity to cover the spread by backing Butler at -8.5 in this college showdown. We can get odds of -105 and this is our best pick.

The college basketball handicappers at Sportsgambler.com stay on top of injuries and team form that could impact the outcome. We also leave no stone unturned when analyzing the latest stats to support every prediction.

Key DePaul vs Butler stats:

• The +8.5 line hasn’t been covered by DePaul in 12 of their last 19 games on the road.
• The +8.5 line hasn’t been covered by DePaul in 3 of their last 5 games on the road.
• The -8.5 line has been covered by Butler in 4 consecutive games against DePaul.

Butler -8.5 Probability

Based on the odds from the top betting sites, there’s a 51.3% likelihood of our pick delivering a return. However, we have this number between 55-60% based on our in-depth research. That means we’re regarding it as a value wager.

Selling points can be a great option and allows bettors to enjoy a bigger return on the same selection. For a more conservative pick, you can alternatively buy points.

Thinking of placing a bet? Make sure to check our guide first — it’s full of the latest offers and welcome bonuses worth claiming.

Our Game Prediction

Butler -8.5 @ -105 Bet Now

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Correct Score Prediction

DePaul 67 - 79 Butler

There’s the chance to land huge betting odds when it comes to the Bulldogs winning on the correct score lines. We’ll try a 79-67 victory in their favor and this should be in the right ball park.

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DePaul vs Butler Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

You might not get rich backing Butler at -333. However, the sportsbooks’ betting odds imply a 77% chance of winning this college game. For those wanting to back DePaul, you will find +260 about the underdogs.

The current spread is 6.5 and the total points line is 148.5. A Total bet is always available and can often provide value selections. There’s the chance to back Under 148.5 at -105.

Consider every angle when placing your college hoops bets. The top basketball betting sites offer a huge selection of game lines and team props, and it’s all about finding a wager that fits your prediction of the game.

Moneyline

DePaul

+260

Butler

-333

Point Spread

DePaul +6.5

-104

Butler -6.5

-118

Total Points

Under 148.5

-105

Over 148.5

-115

As an alternative to the game lines and team props, check out the player props that are available. These can be a great alternative if you want to focus on a player’s performance. The best gambling sites will provide lots of options.

Micro betting is something that’s really popular with bettors, with college basketball fans essentially being able to wager in-game when it comes to score, player and team props. Check out the two-way lines where you can bet whether the next shot will be a Two-pointer or a Three-pointer.

Latest regular season and playoff games stats.

DePaul Stats

Butler Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +8.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +8.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -8.5 Betting Line: Have covered the spread in 2 of the last 10 games
• -8.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 137.20 pts in the previous 10 games
• Game Totals on the Road: An average of 143.10 pts in the previous 10 games on the road
• Over 149.5: Covered in 2 of the previous 10 games
• Over 149.5 on the Road: Covered in 3 of the previous 10 games on the road
• Team Totals: Have scored an average of 69.70 pts and allowed 67.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 67.90 pts and allowed 75.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 156.60 pts in the previous 10 games
• Game Totals at Home: An average of 156.50 pts in the previous 10 home games
• Over 149.5: Covered in 6 of the previous 10 games
• Over 149.5 at Home: Covered in 8 of the previous 10 home games
• Team Totals: Have scored an average of 77.70 pts and allowed 78.90 pts in the last 10 games
• Team Totals at Home: Have scored an average of 81.70 pts and allowed 74.80 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	29-5	2635	2214	421	18-2	11-3	1L
St. John's	28-6	2773	2379	394	18-3	10-3	6W
Villanova	24-8	2469	2265	204	15-4	9-4	1L
Seton Hall	21-12	2321	2156	165	13-5	8-7	1L
DePaul	16-16	2248	2226	22	12-9	4-7	3L
Butler	16-16	2540	2481	59	13-8	3-8	1L
Georgetown	16-18	2503	2479	24	10-8	6-10	1L
Creighton	15-17	2404	2401	3	11-6	4-11	1L
Providence	15-18	2815	2772	43	10-7	5-11	1L
Xavier	15-18	2586	2661	-75	13-7	2-11	1L
Marquette	12-20	2405	2425	-20	10-9	2-11	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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