DePaul vs Creighton Prediction, Picks & Odds | 25 Feb 2026

College Basketball Betting Preview: DePaul vs Creighton

The DePaul Blue Demons face the Creighton Bluejays, with tip-off scheduled for 21:00 on Wednesday, February 25.

We think a wager on the totals provides value after finding that the line is set at a generous 141.5. Expect DePaul and Creighton to surpass this number at -115.

DePaul Blue Demons were defeated in their previous game. They were beaten at home to Providence Friars by a 71-68 scoreline.

Creighton Bluejays suffered a defeat in their last game. A 81-52 scoreline occurred on the road against St. John's Red Storm.

Head-to-Head Statistics

The scoreline was 72-71 in favor of DePaul when they last played Creighton. In the past 10 games between the teams, Creighton have won nine.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
DePaul	14-13	1930	1884	46	12-6	2-7	1L
Creighton	14-14	2120	2119	1	11-4	3-10	1L

View Full Standings

DePaul vs Creighton Prediction & Picks

Our expert DePaul vs Creighton betting tips include a main match prediction, a correct score pick and bet builder advice. Explore each section below for detailed insights.

Game Prediction

We’re forecasting that the two teams will produce a significant combined points total in this college game. Therefore, our pick is to take the -115 that there are Over 141.5 points.

We track all injuries that could impact each team before making our basketball picks. The form guide and latest stats also help the Sportsgambler.com team crunch the numbers ahead of the college hoops action.

Key DePaul vs Creighton stats:

• The 141.5 line has been covered in 9 of the last 10 Creighton games at home.
• The 141.5 line has been covered in 16 of the last 20 Creighton games.
• The 141.5 line has been covered in the last 2 games between these teams.

Over 141.5 Probability

When you look at the latest odds, our pick has a 53.5% chance of landing a return. However, our analysts research has found that the actual probability is closer to 60%. That means we’re regarding it as a value bet.

If you’re wanting bigger odds when wagering on the Totals, then the good news is that you can be in control of the line. Get more juice by betting Over a certain number.

Explore the best betting offers before you stake your money. Our guide showcases a variety of welcome bonuses worth grabbing.

Our Game Prediction

Over 141.5 Points @ -115 Bet Now

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Correct Score Prediction

DePaul 72 - 75 Creighton

We’ll roll the dice and go for the Bluejays to register a 75-72 victory. We don’t think that there will be too much between the teams and we’re happy to take the massive odds.

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DePaul vs Creighton Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With a 71% chance of securing victory, Creighton are favorites for this college game and the sportsbooks have them at betting odds of -250. For those wanting to oppose the market leader, you can get +202 about DePaul.

The spread is calculated to be 5.5, while total points comes in at 141.5. A Total bet is always available and can often provide value selections. If you’re going for Over 141.5, then the odds are -115.

Whether you’re betting pre-game or in-game, the top basketball sportsbooks serve up a wide range of team props and game lines to choose from. The options are nearly endless, and it’s great to have so much variety.

Moneyline

DePaul

+202

Creighton

-250

Point Spread

DePaul +5.5

-115

Creighton -5.5

-105

Total Points

Under 141.5

-105

Over 141.5

-115

The gambling sites will have player props available for each game. Check out the various betting odds and take a view on whether a player’s Total Points, Three-Pointers, Blocks or Steals will hit over or under a certain line.

Among the various options for wagering on college basketball, you will find that micro betting is provided. It focuses on short-term in-game outcomes such as Next Field Goal, where you select if the shot will be a two or three-pointer.

Latest regular season and playoff games stats.

DePaul Stats

Creighton Stats

Moneyline

• 4 wins and 6 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 home games

Point Spread

• +5.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +5.5 Betting Line on the Road: Have covered the spread in 4 of the last 10 games on the road

Point Spread

• -5.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -5.5 Betting Line at Home: Have covered the spread in 2 of the last 10 home games

Total Points

• Game Totals: An average of 140.80 pts in the previous 10 games
• Game Totals on the Road: An average of 139.70 pts in the previous 10 games on the road
• Over 141.5: Covered in 4 of the previous 10 games
• Over 141.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 69.10 pts and allowed 71.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 66.20 pts and allowed 73.50 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 154.00 pts in the previous 10 games
• Game Totals at Home: An average of 158.90 pts in the previous 10 home games
• Over 141.5: Covered in 8 of the previous 10 games
• Over 141.5 at Home: Covered in 9 of the previous 10 home games
• Team Totals: Have scored an average of 72.20 pts and allowed 81.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 79.00 pts and allowed 79.90 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big East	Overall	PF	PA	N. Pts	Home	Away	Strk
UConn	25-3	2218	1848	370	14-2	11-1	1W
St. John's	22-5	2265	1924	341	13-3	9-2	13W
Villanova	21-6	2099	1890	209	13-3	8-3	1L
Seton Hall	19-9	1972	1806	166	12-4	7-5	1W
Butler	15-13	2246	2161	85	13-6	2-7	2W
DePaul	14-13	1930	1884	46	12-6	2-7	1L
Creighton	14-14	2120	2119	1	11-4	3-10	1L
Xavier	13-14	2108	2135	-27	12-6	1-8	2L
Georgetown	13-15	2078	2050	28	9-8	4-7	5L
Providence	12-15	2344	2288	56	9-6	3-9	1W
Marquette	10-18	2121	2156	-35	9-7	1-11	1W

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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