Duke vs Louisville Prediction, Picks & Odds | 06 Jan 2026
College Basketball Betting Preview: Duke vs Louisville
The Duke Blue Devils go up against the Louisville Cardinals, with tip-off scheduled for 19:00 on Tuesday, January 6.
There’s an appealing -102 that Louisville are able to get the better of Duke. This wager can be secured on the Moneyline and we’re confident that it can happen.
Duke Blue Devils triumphed in their previous game. It was on the road where Florida State Seminoles were beaten 91-87.
Louisville Cardinals were beaten last game and this was on the road. Stanford Cardinal claimed a 80-76 win.
Head-to-Head Statistics
Duke won the most recent matchup between these teams. A 73-62 victory was registered against Louisville. It’s been six wins on the bounce for Duke when playing Louisville. On the head-to-head front, they have won 7 of the past 10.
| NCAAB | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
Duke
|
32-2 | 2798 | 2147 | 651 | 21-0 | 11-2 | 11W |
Louisville
|
23-10 | 2797 | 2382 | 415 | 16-2 | 7-8 | 1L |
Duke vs Louisville Prediction & Picks
Step into Duke vs Louisville with confidence, armed with our expert match prediction, likely scoreline, key player prop plays and a custom-built bet builder for maximum value.
Game Prediction
Louisville are on offer at generous -102 when it comes to winning this college contest. Our pick is that they’ll outscore the road team and there’s value available when it comes to these betting odds.
Knowing which players are injured gives us a valuable edge when making basketball predictions. After reviewing the form guide, we turn to the latest stats to shape our college hoops picks.
Key Duke vs Louisville stats:
Louisville Moneyline Probability
The best betting apps make it a 50.5% chance that our pick is settled as a winner. However, our analysts think that the probability is close to 60% taking all factors into consideration. That means we’re regarding it as a value wager.
It’s worth considering all the options. If you’re looking for tastier odds about Louisville to triumph and a certain number of points to be scored, then the Match Result & Total lines could be a good way forward.
Elevate your wagering experience with the latest free bets, promos and top betting offers listed in our comprehensive bonus guide.
Player Prop Picks
Ryan Conwell (Louisville) can be backed to secure Over 4.5 rebounds at -118. We think it’s achievable that he will cover the Player Rebounds line based on the information to hand.
Latest Ryan Conwell Player Prop Odds
Isaac McKneely (Louisville) can be wagered to total Under 11.5 points at -105. It’s anticipated that he might fall short of the mark and that leads us to an Unders bet.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
Take a same game parlay that incorporates Louisville on the moneyline followed by Under 161.5. Add in Ryan Conwell (Louisville) to get Over 4.5 rebounds.
A basketball same game parlay is an awesome way of cheering on different selections within the same game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
76
-
81
Louisville
For those wanting a big return from a small stake, consider the correct score lines. For example, Louisville can be backed to win 81-76 at huge betting odds.
Duke vs Louisville Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
You can choose Louisville at -102 or alternatively Duke who have betting odds of -118. From a percentage point-of-view, the leading sportsbooks give the visiting team a 54% chance of success.
The spread is currently 1.5, with the total points line at 161.5. Basketball fans regularly enjoy the opportunity to bet on the Totals. If you’re going for Under 161.5, this outcome can be backed at -110.
The good news is that you’ll find a strong selection of game lines and team props for most college contests. The best basketball betting sites provide a wide range of pre-game and in-game wagering options.
In terms of landing the most baskets, favorite Cameron Boozer is available at -105 to rack up Over 24.5 points. If you want to go Under, then -123 is available.
There are some exciting college basketball micro betting lines that are created and they are available in-game. Among them are Next Field Goal, where you select if the shot will be a two or three-pointer. The long-ball option pays better, and in today’s game, you can never discount the three-pointer.
- NCAAB: 16/03 2025 Louisville 62 Duke 73
- NCAAB: 09/12 2024 Duke 76 Louisville 65
- NCAAB: 29/02 2024 Louisville 59 Duke 84
- NCAAB: 24/01 2024 Duke 83 Louisville 69
- NCAAB: 21/02 2023 Louisville 62 Duke 79
- NCAAB: 29/01 2022 Duke 74 Louisville 65
- NCAAB: 28/02 2021 Louisville 80 Duke 73
- NCAAB: 23/01 2021 Duke 65 Louisville 70
- NCAAB: 19/01 2020 Louisville 79 Duke 73
- NCAAB: 13/02 2019 Duke 71 Louisville 69
Latest regular season and playoff games stats.
Duke Stats
Louisville Stats
- 9 wins and 1 defeat in the last 10 games
- 8 wins and 2 defeats in the last 10 games on the road
- -1.5 Betting Line: Have covered the spread in 8 of the last 10 games
- -1.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road
- +1.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +1.5 Betting Line at Home: Have covered the spread in 9 of the last 10 home games
- Game Totals: An average of 152.00 pts in the previous 10 games
- Game Totals on the Road: An average of 156.60 pts in the previous 10 games on the road
- Over 161.5: Covered in 4 of the previous 10 games
- Over 161.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 83.80 pts and allowed 68.20 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 87.20 pts and allowed 69.40 pts in the last 10 games on the road
- Game Totals: An average of 153.70 pts in the previous 10 games
- Game Totals at Home: An average of 161.30 pts in the previous 10 home games
- Over 161.5: Covered in 3 of the previous 10 games
- Over 161.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 85.30 pts and allowed 68.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 94.70 pts and allowed 66.60 pts in the last 10 home games
NCAAB Table Select Season
| Atlantic Coast | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
|
Duke
|
32-2 | 2798 | 2147 | 651 | 21-0 | 11-2 | 11W |
Virginia
|
29-5 | 2742 | 2326 | 416 | 19-1 | 10-4 | 1L |
Miami
|
25-8 | 2704 | 2349 | 355 | 16-4 | 9-4 | 1L |
North Carolina
|
24-8 | 2553 | 2282 | 271 | 19-1 | 5-7 | 2L |
Clemson
|
24-10 | 2521 | 2269 | 252 | 16-3 | 8-7 | 1L |
|
Louisville
|
23-10 | 2797 | 2382 | 415 | 16-2 | 7-8 | 1L |
California
|
21-11 | 2492 | 2344 | 148 | 17-4 | 4-7 | 2L |
Stanford
|
20-12 | 2431 | 2326 | 105 | 12-7 | 8-5 | 1L |
NC State
|
20-13 | 2762 | 2525 | 237 | 13-7 | 7-6 | 1L |
SMU
|
20-13 | 2779 | 2561 | 218 | 17-3 | 3-10 | 1L |
Virginia Tech
|
19-13 | 2521 | 2396 | 125 | 15-4 | 4-9 | 2L |
Florida State
|
18-15 | 2652 | 2572 | 80 | 12-8 | 6-7 | 1L |
Wake Forest
|
17-16 | 2602 | 2543 | 59 | 12-6 | 5-10 | 1L |
Syracuse
|
15-17 | 2400 | 2376 | 24 | 12-6 | 3-11 | 6L |
Notre Dame
|
13-18 | 2308 | 2335 | -27 | 11-7 | 2-11 | 2L |
Pittsburgh
|
13-20 | 2327 | 2370 | -43 | 8-10 | 5-10 | 1L |
Boston College
|
11-20 | 2090 | 2191 | -101 | 10-10 | 1-10 | 1W |
Georgia Tech
|
11-20 | 2287 | 2400 | -113 | 10-10 | 1-10 | 12L |
- Overall = Overall Wins-Losses
- PF = Total Points For
- PA = Total Points Against
- N. Pts = Point Differential
- Home = Home Record
- Away = Away Record
- Strk = Current Streak
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