Louisville vs Duke Prediction, Picks & Odds | 26 Jan 2026

College Basketball Betting Preview: Louisville vs Duke

The Louisville Cardinals go up against the Duke Blue Devils, with tip-off scheduled for 19:00 on Monday, January 26.

The market might have underrated Louisville and -110 makes plenty of appeal considering the underdogs are +7.5 on the spread. Back them to cover the line against Duke.

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Louisville Cardinals won their previous game which was at home. It was a 85-71 triumph against Virginia Tech.

Duke Blue Devils last game saw them claim a 90-69 home win over Wake Forest Demon Deacons.

Head-to-Head Statistics

It was a 84-73 win for Duke when they last played Louisville. Duke have won seven on the spin against Louisville. They’ve also claimed 7 wins in the past 10 head-to-head matchups.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	18-1	1629	1240	389	11-0	7-1	7W
Louisville	14-5	1668	1323	345	10-2	4-3	2W

View Full Standings

Louisville vs Duke Prediction & Picks

Get the edge with our best Louisville vs Duke picks: a key match prediction, correct score recommendation and a ready-made bet builder. Explore each section below for detailed insights.

Game Prediction

We’ve lined up a pick which requires Louisville to keep close to the favorites in this college contest. We think that the betting line of +7.5 can be covered and you can secure -110.

Our team of college basketball handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Louisville vs Duke stats:

• The +7.5 line has been covered by Louisville in 16 of their last 20 games on the road.
• The +7.5 line has been covered by Louisville in 4 of their last 5 games on the road.
• The +7.5 line has been covered by Louisville in 3 consecutive games on the road.
• The -7.5 line hasn’t been covered by Duke in 3 of their last 5 games at home.

Louisville +7.5 Probability

The latest odds at the best betting apps suggest our pick carries a 52.4% chance of winning. However, our analysts research has found that the actual probability is closer to 60%. This is why we regard this as a value bet.

It’s good to explore all avenues and you might prefer bigger odds about the selection you want to make. Go ahead and move the line until you’re happy with the price.

Don’t miss out on extra value. Our comprehensive guide features a wide range of free bets and sign-up bonuses for new bettors.

Our Game Prediction

Louisville +7.5 @ -110 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (23:56, 25 January 2026). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Louisville 74 - 78 Duke

We’re expecting this to be a close game and we’ll take Duke to win 78-74. This is available at huge odds for those that want to have a speculative wager.

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Louisville vs Duke Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With the sportsbooks giving them a 77% probability of winning this college game, Duke might be a popular parlay pick. That is reflected in their -333 Moneyline betting odds. For those wanting to oppose the market leader, you can get +265 about Louisville.

There is a spread of 7.5 and total points has a line of 157.5. A bet on the Totals allows fans to use the latest basketball data to good effect. There’s the chance to back Under 157.5 at -114.

If you’re planning to place a bet on a college hoops matchup, visit the top basketball betting sites and check out the many available game lines and team props. Find the lines which are the most attractive.

Moneyline

Louisville

+265

Duke

-333

Point Spread

Louisville +7.5

-110

Duke -7.5

-110

Total Points

Under 157.5

-114

Over 157.5

-106

The gambling sites will have player props available for each game. Check out the various betting odds and take a view on whether a player’s Total Points, Three-Pointers, Blocks or Steals will hit over or under a certain line.

An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Latest regular season and playoff games stats.

Louisville Stats

Duke Stats

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 6 wins and 4 defeats in the last 10 games on the road

Moneyline

• 9 wins and 1 defeat in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• +7.5 Betting Line: Have covered the spread in 7 of the last 10 games
• +7.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road

Point Spread

• -7.5 Betting Line: Have covered the spread in 5 of the last 10 games
• -7.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

• Game Totals: An average of 153.90 pts in the previous 10 games
• Game Totals on the Road: An average of 149.90 pts in the previous 10 games on the road
• Over 157.5: Covered in 3 of the previous 10 games
• Over 157.5 on the Road: Covered in 4 of the previous 10 games on the road
• Team Totals: Have scored an average of 82.40 pts and allowed 71.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 77.70 pts and allowed 72.20 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 153.10 pts in the previous 10 games
• Game Totals at Home: An average of 152.90 pts in the previous 10 home games
• Over 157.5: Covered in 5 of the previous 10 games
• Over 157.5 at Home: Covered in 4 of the previous 10 home games
• Team Totals: Have scored an average of 82.70 pts and allowed 70.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 88.70 pts and allowed 64.20 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	18-1	1629	1240	389	11-0	7-1	7W
Virginia	16-3	1592	1292	300	11-1	5-2	1L
Clemson	17-4	1619	1368	251	12-1	5-3	1W
Miami	16-4	1699	1386	313	11-2	5-2	1W
North Carolina	16-4	1651	1401	250	13-0	3-4	2W
SMU	15-5	1745	1540	205	13-1	2-4	2W
California	15-5	1575	1405	170	14-2	1-3	2W
Louisville	14-5	1668	1323	345	10-2	4-3	2W
Virginia Tech	15-6	1711	1566	145	12-1	3-5	1L
NC State	14-6	1706	1437	269	9-4	5-2	2W
Stanford	14-6	1519	1449	70	9-5	5-1	2L
Syracuse	12-8	1513	1379	134	9-4	3-4	3L
Wake Forest	11-9	1607	1531	76	8-4	3-5	2L
Notre Dame	11-9	1458	1402	56	9-3	2-6	1W
Georgia Tech	11-9	1499	1465	34	10-5	1-4	1L
Boston College	9-11	1364	1363	1	8-6	1-5	1L
Pittsburgh	8-12	1453	1425	28	6-7	2-5	3L
Florida State	8-12	1626	1610	16	7-6	1-6	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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