Louisville vs Duke Prediction, Picks & Odds | 26 Jan 2026
College Basketball Betting Preview: Louisville vs Duke
The Louisville Cardinals go up against the Duke Blue Devils, with tip-off scheduled for 19:00 on Monday, January 26.
The market might have underrated Louisville and -110 makes plenty of appeal considering the underdogs are +7.5 on the spread. Back them to cover the line against Duke.
Louisville Cardinals won their previous game which was at home. It was a 85-71 triumph against Virginia Tech.
Duke Blue Devils last game saw them claim a 90-69 home win over Wake Forest Demon Deacons.
Head-to-Head Statistics
It was a 84-73 win for Duke when they last played Louisville. Duke have won seven on the spin against Louisville. They’ve also claimed 7 wins in the past 10 head-to-head matchups.
| NCAAB | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
Duke
|
32-2 | 2798 | 2147 | 651 | 21-0 | 11-2 | 11W |
Louisville
|
23-10 | 2797 | 2382 | 415 | 16-2 | 7-8 | 1L |
Louisville vs Duke Prediction & Picks
From our main match prediction to correct score advice, must-watch player props and a custom bet builder — this Louisville vs Duke betting preview covers it all.
Game Prediction
We’ve lined up a pick which requires Louisville to keep close to the favorites in this college contest. We think that the betting line of +7.5 can be covered and you can secure -110.
Our team of college basketball handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.
Key Louisville vs Duke stats:
Louisville +7.5 Probability
The latest odds at the best betting apps suggest our pick carries a 52.4% chance of winning. However, our analysts research has found that the actual probability is closer to 60%. This is why we regard this as a value bet.
It’s good to explore all avenues and you might prefer bigger odds about the selection you want to make. Go ahead and move the line until you’re happy with the price.
Don’t miss out on extra value. Our comprehensive guide features a wide range of free bets and sign-up bonuses for new bettors.
Player Prop Picks
Ryan Conwell (Louisville) can be backed to register Over 2.5 assists at +140. We can place a Player Assists bet with confidence, with our pick expected to cover the total.
Latest Ryan Conwell Player Prop Odds
Mikel Brown Jr. (Louisville) can be backed to register Over 2.5 rebounds at -137. We recommend taking the pick that he is able to cover the line, with this Player Rebounds bet hopefully providing a return.
Latest Mikel Brown Jr. Player Prop Odds
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve compiled a same game parlay that includes Louisville +7.5 on the spread, along with Under 157.5 and Ryan Conwell (Louisville) to get Over 2.5 assists.
A basketball same game parlay is a single event wager where you make predictions that are going to happen in a particular game. Should a bettor get these picks correct, then they can achieve a big payout from a small stake.
Correct Score Prediction
74
-
78
Duke
We’re expecting this to be a close game and we’ll take Duke to win 78-74. This is available at huge odds for those that want to have a speculative wager.
Louisville vs Duke Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
With the sportsbooks giving them a 82% probability of winning this college game, Duke might be a popular parlay pick. That is reflected in their -455 Moneyline betting odds. For those wanting to oppose the market leader, you can get +340 about Louisville.
There is a spread of 8.5 and total points has a line of 157.5. A bet on the Totals allows fans to use the latest basketball data to good effect. There’s the chance to back Under 157.5 at -114.
If you’re planning to place a bet on a college hoops matchup, visit the top basketball betting sites and check out the many available game lines and team props. Find the lines which are the most attractive.
Cameron Boozer is the market leader to land the most baskets. He is priced at -111 to score Over 24.5 points. Alternatively, you can back Under at -116.
An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.
- NCAAB: 07/01 2026 Duke 84 Louisville 73
- NCAAB: 16/03 2025 Louisville 62 Duke 73
- NCAAB: 09/12 2024 Duke 76 Louisville 65
- NCAAB: 29/02 2024 Louisville 59 Duke 84
- NCAAB: 24/01 2024 Duke 83 Louisville 69
- NCAAB: 21/02 2023 Louisville 62 Duke 79
- NCAAB: 29/01 2022 Duke 74 Louisville 65
- NCAAB: 28/02 2021 Louisville 80 Duke 73
- NCAAB: 23/01 2021 Duke 65 Louisville 70
- NCAAB: 19/01 2020 Louisville 79 Duke 73
Latest regular season and playoff games stats.
Louisville Stats
Duke Stats
- 6 wins and 4 defeats in the last 10 games
- 6 wins and 4 defeats in the last 10 games on the road
- +7.5 Betting Line: Have covered the spread in 7 of the last 10 games
- +7.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- -7.5 Betting Line: Have covered the spread in 5 of the last 10 games
- -7.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games
- Game Totals: An average of 153.90 pts in the previous 10 games
- Game Totals on the Road: An average of 149.90 pts in the previous 10 games on the road
- Over 157.5: Covered in 3 of the previous 10 games
- Over 157.5 on the Road: Covered in 4 of the previous 10 games on the road
- Team Totals: Have scored an average of 82.40 pts and allowed 71.50 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 77.70 pts and allowed 72.20 pts in the last 10 games on the road
- Game Totals: An average of 153.10 pts in the previous 10 games
- Game Totals at Home: An average of 152.90 pts in the previous 10 home games
- Over 157.5: Covered in 5 of the previous 10 games
- Over 157.5 at Home: Covered in 4 of the previous 10 home games
- Team Totals: Have scored an average of 82.70 pts and allowed 70.40 pts in the last 10 games
- Team Totals at Home: Have scored an average of 88.70 pts and allowed 64.20 pts in the last 10 home games
NCAAB Table Select Season
| Atlantic Coast | Overall | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|
|
Duke
|
32-2 | 2798 | 2147 | 651 | 21-0 | 11-2 | 11W |
Virginia
|
29-5 | 2742 | 2326 | 416 | 19-1 | 10-4 | 1L |
Miami
|
25-8 | 2704 | 2349 | 355 | 16-4 | 9-4 | 1L |
North Carolina
|
24-8 | 2553 | 2282 | 271 | 19-1 | 5-7 | 2L |
Clemson
|
24-10 | 2521 | 2269 | 252 | 16-3 | 8-7 | 1L |
|
Louisville
|
23-10 | 2797 | 2382 | 415 | 16-2 | 7-8 | 1L |
California
|
21-11 | 2492 | 2344 | 148 | 17-4 | 4-7 | 2L |
Stanford
|
20-12 | 2431 | 2326 | 105 | 12-7 | 8-5 | 1L |
NC State
|
20-13 | 2762 | 2525 | 237 | 13-7 | 7-6 | 1L |
SMU
|
20-13 | 2779 | 2561 | 218 | 17-3 | 3-10 | 1L |
Virginia Tech
|
19-13 | 2521 | 2396 | 125 | 15-4 | 4-9 | 2L |
Florida State
|
18-15 | 2652 | 2572 | 80 | 12-8 | 6-7 | 1L |
Wake Forest
|
17-16 | 2602 | 2543 | 59 | 12-6 | 5-10 | 1L |
Syracuse
|
15-17 | 2400 | 2376 | 24 | 12-6 | 3-11 | 6L |
Notre Dame
|
13-18 | 2308 | 2335 | -27 | 11-7 | 2-11 | 2L |
Pittsburgh
|
13-20 | 2327 | 2370 | -43 | 8-10 | 5-10 | 1L |
Boston College
|
11-20 | 2090 | 2191 | -101 | 10-10 | 1-10 | 1W |
Georgia Tech
|
11-20 | 2287 | 2400 | -113 | 10-10 | 1-10 | 12L |
- Overall = Overall Wins-Losses
- PF = Total Points For
- PA = Total Points Against
- N. Pts = Point Differential
- Home = Home Record
- Away = Away Record
- Strk = Current Streak
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