Louisville vs Indiana Prediction, Picks & Odds | 06 Dec 2025

College Basketball Betting Preview: Louisville vs Indiana

The Louisville Cardinals face the Indiana Hoosiers, with tip-off scheduled for 14:15 on Saturday, December 6.

Let’s shoot for a total bet between Louisville and Indiana, with Under 157.5 points available at odds of -105. This betting prediction has plenty of juice in the price.

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Louisville Cardinals were defeated in their previous game. On the road, they suffered a 89-80 reverse against Arkansas Razorbacks.

Indiana Hoosiers were defeated in their last game. On the road, they suffered a 73-64 reverse against Minnesota Golden Gophers.

Head-to-Head Statistics

Louisville triumphed 89-61 when they last played Indiana. It’s been two Indiana wins in the past 3 games between these teams.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
Indiana	7-1	691	510	181	7-0	0-1	1L
Louisville	7-1	757	530	227	6-0	1-1	1L

View Full Standings

Louisville vs Indiana Prediction & Picks

Dive into our Louisville vs Indiana betting tips, featuring an expert match prediction, our best correct score pick and a ready-made bet builder designed for value.

Game Prediction

The -105 about Under 157.5 points makes lots of appeal. We’re not sure that the teams can combine to reach that number for this college matchup.

We track all injuries that could impact each team before making our basketball picks. The form guide and latest stats also help the Sportsgambler.com team crunch the numbers ahead of the college hoops action.

Key Louisville vs Indiana stats:

• The 157.5 line hasn’t been covered in 8 of the last 10 Louisville games on the road.
• The 157.5 line hasn’t been covered in 4 of the last 5 Louisville games on the road.
• The 157.5 line hasn’t been covered in the last 5 Indiana games.
• The 157.5 line hasn’t been covered in 17 of the last 20 Indiana games.
• The 157.5 line hasn’t been covered in 8 of the last 10 Indiana games.
• The 157.5 line hasn’t been covered in the last 3 games between these teams.

Under 157.5 Probability

The best sportsbooks are estimating that there is a 51.3% likelihood of this pick delivering a return. In the opinion of our analysts, there’s actually a probability of success closer to 60%. It’s why we think it’s worth placing this college basketball wager.

More juice from your Unders wager can be found by combining this selection on the Match Result & Total lines. Choose the odds which match your prediction.

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Our Game Prediction

Under 157.5 Points @ -105 Bet Now

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Correct Score Prediction

Louisville 77 - 75 Indiana

We’ll roll the dice and go for Louisville to register a 77-75 victory. We don’t think that there will be too much between the teams and we’re happy to take the massive odds.

Louisville vs Indiana Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

For this college game, the sportsbooks’ Moneyline betting odds mean Louisville are -233 favorites to win and that means a 70% chance of landing a victory. Indiana are trading at bigger odds than their opponents and they can be backed at +190.

5.5 is where the spread lies, with total points being 157.5 right now. A Total bet is always available and can often provide value selections. If you want to bet Under 157.5, there are odds of -105.

You can find a nice selection of game lines and team props for most college basketball matchups, with the top betting apps creating many different options. Check out the pre-game and in-game selections before placing your bets.

Moneyline

Louisville

-233

Indiana

+190

Point Spread

Louisville -5.5

-102

Indiana +5.5

-120

Total Points

Under 157.5

-105

Over 157.5

-115

As an alternative to the game lines and team props, check out the player props that are available. These can be a great alternative if you want to focus on a player’s performance. The best gambling sites will provide lots of options.

An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Latest regular season and playoff games stats.

Louisville Stats

Indiana Stats

Moneyline

• 7 wins and 3 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• -5.5 Betting Line: Have covered the spread in 7 of the last 10 games
• -5.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• +5.5 Betting Line: Have covered the spread in 8 of the last 10 games
• +5.5 Betting Line at Home: Have covered the spread in the last 10 home games

Total Points

• Game Totals: An average of 158.60 pts in the previous 10 games
• Game Totals on the Road: An average of 147.70 pts in the previous 10 games on the road
• Over 157.5: Covered in 5 of the previous 10 games
• Over 157.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 89.40 pts and allowed 69.20 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 79.00 pts and allowed 68.70 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 145.80 pts in the previous 10 games
• Game Totals at Home: An average of 148.20 pts in the previous 10 home games
• Over 157.5: Covered in 2 of the previous 10 games
• Over 157.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 81.60 pts and allowed 64.20 pts in the last 10 games
• Team Totals at Home: Have scored an average of 84.90 pts and allowed 63.30 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Big Ten	Overall	PF	PA	N. Pts	Home	Away	Strk
Michigan State	8-0	629	483	146	6-0	2-0	8W
USC	8-0	725	620	105	5-0	3-0	8W
Purdue	8-0	709	541	168	6-0	2-0	8W
Michigan	7-0	656	473	183	5-0	2-0	7W
Nebraska	8-0	678	561	117	8-0	0-0	8W
Penn State	8-1	748	630	118	7-1	1-0	3W
Indiana	7-1	691	510	181	7-0	0-1	1L
Iowa	7-1	636	499	137	6-0	1-1	1L
Ohio State	6-1	621	471	150	6-0	0-1	1L
UCLA	6-2	621	522	99	5-1	1-1	1W
Wisconsin	6-2	695	588	107	5-0	1-2	1W
Illinois	6-2	723	562	161	6-2	0-0	1L
Maryland	6-3	707	702	5	5-1	1-2	1W
Northwestern	5-3	648	572	76	4-2	1-1	2L
Washington	5-3	658	589	69	3-1	2-2	2L
Minnesota	5-4	661	611	50	5-3	0-1	1W
Rutgers	5-4	639	622	17	5-2	0-2	1L
Oregon	4-4	593	605	-12	4-3	0-1	4L

Atlantic Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Duke	9-0	802	536	266	7-0	2-0	9W
SMU	8-1	805	680	125	7-0	1-1	1L
Louisville	7-1	757	530	227	6-0	1-1	1L
Virginia	7-1	701	542	159	5-0	2-1	2W
North Carolina	7-1	650	524	126	6-0	1-1	1W
California	7-1	670	559	111	7-0	0-1	4W
Stanford	7-1	663	575	88	5-1	2-0	3W
Virginia Tech	7-2	747	674	73	5-0	2-2	1W
Clemson	7-2	766	600	166	6-0	1-2	1L
Miami	7-2	768	589	179	5-1	2-1	2W
Wake Forest	6-3	767	661	106	5-1	1-2	1L
Notre Dame	6-3	679	609	70	6-0	0-3	1W
NC State	5-3	728	619	109	4-1	1-2	2L
Syracuse	5-3	586	517	69	4-0	1-3	1W
Florida State	5-3	691	624	67	5-2	0-1	2L
Pittsburgh	5-4	645	613	32	5-2	0-2	1L
Georgia Tech	5-4	645	625	20	5-2	0-2	3L
Boston College	4-5	633	603	30	3-4	1-1	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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