Loyola Chicago vs San Francisco Prediction, Picks & Odds | 17 Dec 2025

College Basketball Betting Preview: Loyola Chicago vs San Francisco

The Loyola Chicago Ramblers battle the San Francisco Dons, with tip-off scheduled for 22:00 on Wednesday, December 17.

San Francisco can enjoy a huge victory and a wager on the spread could be the best way forward. Back the big favorites off -12.5 to cover the line against Loyola Chicago at -120.

Loyola Chicago Ramblers were defeated in their previous game. They were beaten at home to Chicago State Cougars by a 84-75 scoreline.

San Francisco Dons lost on the road in their last game. Saint Louis Billikens won 85-75.

Head-to-Head Statistics

It was a 77-76 win for Loyola Chicago when they last played San Francisco. Loyola Chicago have won two of the past 3 games that these teams have played.

NCAAB	Overall	PF	PA	N. Pts	Home	Away	Strk
San Francisco	17-16	2464	2414	50	11-6	6-10	1L
Loyola Chicago	9-24	2204	2500	-296	6-12	3-12	1L

View Full Standings

Loyola Chicago vs San Francisco Prediction & Picks

Our expert Loyola Chicago vs San Francisco betting tips include a main match prediction, a correct score pick and bet builder advice. Explore each section below for detailed insights.

Game Prediction

We’re confident that San Francisco can enjoy a big win in this college matchup, leading us to go against the spread at -12.5. The line makes lots of appeal and there are odds of -120 that can be taken for the favorites.

Our team of college basketball handicappers track current injuries closely. Combined with recent form, this helps us identify the best value odds. A data-led approach backed by key stats and the latest team news keeps our analysis sharp.

Key Loyola Chicago vs San Francisco stats:

• The -12.5 line has been covered by San Francisco in 2 of their last 5 games at home.

San Francisco -12.5 Probability

The top betting sites are estimating that there is a 54.6% likelihood of this pick winning. Taking all factors into consideration, our analysts think there’s a stronger chance of success and estimate the probability to be closer to 60%. It’s why we think it’s worth placing this college basketball bet.

The betting sites give you the chance to buy or sell points, meaning that you can select from a variety of lines. Buying means shorter prices, with selling sending the odds upwards.

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Our Game Prediction

San Francisco -12.5 @ -120 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Dec 17, 02:56). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Loyola Chicago 65 - 82 San Francisco

There’s the chance to back San Francisco in lots of different ways and this includes predicting the correct winning score. We’ll go for a 82-65 victory in their favor.

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Loyola Chicago vs San Francisco Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With an estimated 90% chance of winning, the sportsbooks are taking no chances with their -909 betting odds about San Francisco triumphing in this college game. If you’re looking for an alternative angle, Loyola Chicago are trading at +590.

The spread is 12.5 and the total points line is currently 142.5. There is no denying the popularity of betting on the Totals. The Over 142.5 selection is available to back at -115.

Whether you’re betting in-game or pre-game, the best betting apps serve up a wide range of game lines and team props to choose from. The options are nearly endless, and it’s awesome to have so much variety.

Moneyline

Loyola Chicago

+590

San Francisco

-909

Point Spread

Loyola Chicago +12.5

-115

San Francisco -12.5

-105

Total Points

Under 142.5

-105

Over 142.5

-115

The gambling sites also allow you to place player prop bets such as Points, Assists, Steals and Rebounds. This means you can focus on an individual player’s performance rather than wager on the actual outcome of the game in question.

An increasing number of bettors are now enjoying micro betting on college basketball and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Latest regular season and playoff games stats.

Loyola Chicago Stats

San Francisco Stats

Moneyline

• 2 wins and 8 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 games on the road

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +12.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +12.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

• -12.5 Betting Line: Have covered the spread in 1 of the last 10 games
• -12.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 140.70 pts in the previous 10 games
• Game Totals on the Road: An average of 145.20 pts in the previous 10 games on the road
• Over 142.5: Covered in 4 of the previous 10 games
• Over 142.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 66.00 pts and allowed 74.70 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 70.80 pts and allowed 74.40 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 143.40 pts in the previous 10 games
• Game Totals at Home: An average of 147.80 pts in the previous 10 home games
• Over 142.5: Covered in 6 of the previous 10 games
• Over 142.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 72.30 pts and allowed 71.10 pts in the last 10 games
• Team Totals at Home: Have scored an average of 78.70 pts and allowed 69.10 pts in the last 10 home games

NCAAB Table Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

West Coast	Overall	PF	PA	N. Pts	Home	Away	Strk
Gonzaga	30-3	2809	2178	631	20-0	10-3	2W
Saint Mary's	27-5	2502	2066	436	18-1	9-4	1L
Santa Clara	26-8	2817	2463	354	16-3	10-5	1L
Seattle	20-13	2373	2211	162	15-5	5-8	1L
Pacific	18-15	2399	2271	128	13-3	5-12	1L
Oregon State	17-16	2347	2447	-100	13-8	4-8	1L
San Francisco	17-16	2464	2414	50	11-6	6-10	1L
Loyola Marymount	15-17	2376	2306	70	10-10	5-7	2L
Portland	14-19	2426	2582	-156	12-6	2-13	1L
San Diego	12-21	2458	2570	-112	9-8	3-13	1L
Washington State	11-20	2435	2495	-60	9-8	2-12	4L
Pepperdine	9-23	2312	2546	-234	7-10	2-13	1L

Atlantic 10	Overall	PF	PA	N. Pts	Home	Away	Strk
Saint Louis	28-5	2879	2294	585	21-2	7-3	1L
VCU	27-7	2773	2430	343	19-3	8-4	6W
George Mason	23-9	2347	2160	187	17-3	6-6	1L
Dayton	23-11	2528	2376	152	16-4	7-7	1L
Saint Joseph's	22-11	2419	2306	113	16-3	6-8	1L
Davidson	20-13	2367	2225	142	12-8	8-5	1L
Duquesne	18-15	2584	2481	103	13-7	5-8	1L
George Washington	18-15	2708	2433	275	13-5	5-10	1L
Fordham	17-15	2235	2095	140	12-8	5-7	1L
Rhode Island	16-16	2236	2182	54	10-7	6-9	2L
St. Bonaventure	17-17	2596	2532	64	10-7	7-10	1L
Richmond	15-17	2455	2366	89	11-8	4-9	4L
La Salle	9-23	2148	2370	-222	7-9	2-14	2L
Loyola Chicago	9-24	2204	2500	-296	6-12	3-12	1L

• Overall = Overall Wins-Losses
• PF = Total Points For
• PA = Total Points Against
• N. Pts = Point Differential
• Home = Home Record
• Away = Away Record
• Strk = Current Streak

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